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Chrissy, sorry to hear the news. It's so discouraging to have to switch gears again, I know what you're going through but that you have a plan forming is good. Keep a repeat of Taxol/Carbo/Herceptin on the back burner, since it was successful before. We've had some success restarting chemos that I responded to in the past, as long as I didn't have real resistance develop. My onc's rule of thumb is waiting at least a year before reusing a chemo. We added Navelbine to my maintenance Herceptin 3 seperate times until I became resistant. Now we're restarting Taxol with Avastin/Carbo(which I've not had) and I'm showing response. It seems as if you haven't had a lot of different chemo combo's so you've got options, which is hopeful.
Hang in there, let us know what you and your onc come up with.
<3 Lolly
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Sept.'99 - Dx.Stage IIIB, IDC ER/PR-, HER2+++ by IHC, confirmed '04 by FISH. Left MRM, AC x's 4, Taxol x's 4, 33 Rads, finishing Tx May 2000. Jan.'01 - local/regional recurrence, Stage IV. Herceptin/Navelbine weekly till NED August 2001, then maintenance Herceptin. Right Mast. April 2002. Local/Regional recurrence April '04, Herceptin plus/minus chemo until May '07. Gemzar added from Feb.'07-April '07; Tykerb/Abraxane until August '07, back on Herceptin plus Taxotere and Xeloda Sept. '07. Stopped T/X Nov. '07, stopped Herceptin Dec. '07, started Avastin/Taxol/Carboplatin Dec. '07. Progression in chest skin, stopped TAC March '03, started radiation.
Herceptin has served as the "Backbone" of my treatment strategy for over 6 years, giving me great quality of life. In 2005, I was privileged to participate in the University of Washington/Seattle HER2 Vaccine Trial.
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