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11-28-2007, 05:35 PM
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#1
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Senior Member
Join Date: Jun 2006
Location: San Antonio, TX
Posts: 2,357
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MichelleH how are you....
and what did you find out today at the doctor's appt.? ma
__________________
MA in TX.
Grateful for each and every day....
Diag. 12/05 at age 60
Stage II, Grade 3, 4.5 cm primary tumor
ER/PR- Her2 +3 strongly positive
Her2 by FISH 7.7 amplified
vascular invasion
Ki67 20% borderline
Jan - March '06 Taxotere/Adriamycin X 3 to try to shrink tumor - it grew
April '06 Rt Modified Radical Mas, 7 of 9 nodes positive
April - Aug. '06 Herceptin/Taxol/Carboplatin X 8 (dose dense)
Sept - Dec. '06 Navelbine/Herceptin x 8 (dose dense)
Radiation & Herceptin Jan. 22 - March 1, 2007
Finished Herceptin Dec. 10 '08! One extra year.
Port removed August, 2012.
8 1/2 years since diagnosis! 5 1/2 Years NED!
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11-28-2007, 06:31 PM
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#2
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Senior Member
Join Date: May 2007
Location: Northern Michigan
Posts: 68
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Ma,
Thanks for your concerns MA,
Doc said he has read a recent article (which he gave me a copy of) about single agents being just as successful as combined chemo agents. So he suggested using Taxetere alone. We have told my doc that we are planning a trip to Mayo for 2nd opinion which my doctor happily set up for me. Until then, he wants to drop Tykerb & keep me on Xeloda and add Avastin. He ask me if I knew any thing about Avastin and I told him I knew it restricted new blood supply to tumors. He was quit impressed!!! I gave all the credit to this site and to all of its knowledgeable members. He was also impressed to hear that there was such a site for us Her2 neus. My appt (tentative) for Mayo is Jan 8th. They are reviewing my case and may bump up my appointment up sooner. So that is where we are now.
Myself as how I am doing, I am having pain in the bones & liver, not too severe, but taking a pain pill so I can get comfortable to sleep at night. I took my time to cry and now I am back on my feet ready to duke it out with this junk once more (thanks to the support from my warriors here on this site and abroad). Thank you all.
I will be posting a a question about Avastin. I hope those that have been on it can give me some feedback.
Love & hugs,
Michelle
__________________
Sept. 2003- 5cm tumor in left breast Her2+ Er- Pr- grade 3,
Mastectomy & 11 nodes removed, all negative.
4 rounds A/C + 12 wky Taxol
25 rads
Dec 2006- recurrence Stage IV (diagnosed 3 days before Christmas!) Lymph nodes in chest, liver, 3 ribs
January 2007- 3 tri wkly rounds of Taxol/Herceptin
Response to lymph nodes in chest, but several more bone mets (skull, shoulders, more ribs, femur, several on spine), liver tumors still growing.
March 2007- 8 wkly rounds of Navelbine/Herceptin/ every 4th wk Zometa
Lymph nodes in chest look great, but more bone mets (of course!), Clavicles, hips, and sacrum (above tail bone) to add to the list. Liver mets still growing.
June 5- started Tykerb/Xeloda
Aug 14- Scans are showing great progress! Tumor shrinkage and bones are healing!
Nov 21 CT scan shows tumor growth in liver & bones next Doc appt on 11-27
Dire need of a lot of prayers and a miracle.
Stay at home mom, 5 yr old girl & 8 yr old boy.
Wife of loving husband
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11-28-2007, 06:55 PM
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#3
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Senior Member
Join Date: Jun 2006
Location: San Antonio, TX
Posts: 2,357
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Hi Michelle!
I'm so glad that you are getting a 2nd opinion and that your doc. is helping make it happen. I hope they fit you in really soon; so that your brain can focus on other things! I go to treatment with a friend who has had really good results from Avastin.
I know that you will get masterful advice and support from this gang of warriors! Keep believing. I'll add my prayers for your quick turn around with "working" drugs!
ma
__________________
MA in TX.
Grateful for each and every day....
Diag. 12/05 at age 60
Stage II, Grade 3, 4.5 cm primary tumor
ER/PR- Her2 +3 strongly positive
Her2 by FISH 7.7 amplified
vascular invasion
Ki67 20% borderline
Jan - March '06 Taxotere/Adriamycin X 3 to try to shrink tumor - it grew
April '06 Rt Modified Radical Mas, 7 of 9 nodes positive
April - Aug. '06 Herceptin/Taxol/Carboplatin X 8 (dose dense)
Sept - Dec. '06 Navelbine/Herceptin x 8 (dose dense)
Radiation & Herceptin Jan. 22 - March 1, 2007
Finished Herceptin Dec. 10 '08! One extra year.
Port removed August, 2012.
8 1/2 years since diagnosis! 5 1/2 Years NED!
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11-28-2007, 06:57 PM
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#4
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Senior Member
Join Date: Aug 2006
Location: So California
Posts: 223
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Thanks for the update
Thanks for the update Michelle. I have been thinking about you and praying for answers. You sound like you are ready to fight once again. That is awesome. Keep up the fight. I will keep up the prayers!
Lisa
__________________
Leslie's Sister (Lisa)
Diagnosed 5/17/06
Left breast Stage II
5 cm. Her2Neu+++, ER-, PR-
1 positive node out of six,
double mastectomy 6/9/06;
TCH started 7/12/06
last chemo 10/25/06
herceptin ended 6-11-07
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11-28-2007, 07:08 PM
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#5
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Senior Member
Join Date: Jun 2007
Location: moved to Lancaster, Pa in June, 2010
Posts: 576
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Thanks for updating us. I have been praying for you that you return to NED soon. Keep on fighting and kicking this cancer in the rear!!!!!
__________________
Debbie in North Carolina
Diag 10/2006-high grade invasive ductal carcinoma- mastectomy L breast
2.5 cm tumor ER/PR pos-Her2+++
4 rounds A/C, 4 rounds Taxol
Herceptin every 3 weeks until Jan. 2008
6/18/07 prophylatic mastectomy R breast
8/2007 started aromasin/stopped arimidex (side effects)
12/07 stopped aromasin due to side effects (now what?)
Finished herceptin 1/8/08
started tamoxifen for 2 years then will switch to femera
allergic to tamoxifen started femera 4/2008
June 20, 2008 portacath removed
Learnig to live life to the fullest!
Stopped Femera due to side effects
July 28, 2008 start trial for breast cancer vaccine
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11-28-2007, 07:11 PM
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#6
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Senior Member
Join Date: Aug 2006
Location: Sheboygan, WI
Posts: 2,582
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Hi Michelle,
I was happy to hear that you were going to Mayo for a second opinion. I, too, will pray your appointment can be moved closer and that God's Peace and Comfort sustains you while you wait.
Love and hugs,
Mary Jo
__________________
"Be still and know that I am God." Psalm 46:10
Dx. 6/24/05 age 45 Right Breast IDC ER/PR. Neg., - Her2+++ RB Mast. - 7/28/05 - 4 cm. tumor Margins clear - 1 microscopic cell 1 sent. node No Vasucular Invasion 4 DD A/C - 4 DD Taxol & Herceptin 1 full year of Herceptin received every 3 weeks 28 rads prophylactic Mast. 3/2/06
17 Years NED
<>< Romans 8:28
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11-28-2007, 07:16 PM
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#7
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Senior Member
Join Date: Jun 2007
Location: Bergenfield, NJ
Posts: 121
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Hi Michelle,
You are in my prayers. I think about you. Thank you for the private message. I'm still on Herceptin/Navalbine combo weekly. My next scan is this month or next month I think :-(
It seems like your onc is a very caring person. My onc left in Sept. because she'll only be doing leukemia now.I was really sad when she told me she was leaving because I really like her and felt so comfortable with her. So my new onc which I have only been seen once since Sept. (i only see my NP which is really a nice person) does not seem to be caring and no bed side manner... :-(
Michelle, i hope this new drug combo will work. Good luck. I'm glad you're going for a second opinion. You'll be in good hands. God will send his healing hands through your onc.
I can't help to cry while typing this. It seems like I've known you for so long. I always read your post and our sisters here. I'm learning so much.
I'm taking oxycontin and oxycodone for my pain. It helps. I say.....thank goodness for pain meds!!!
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11-28-2007, 07:25 PM
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#8
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Senior Member
Join Date: Feb 2006
Location: Acworth, GA
Posts: 2,104
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Michelle,
Seems like you have an oncologist who is willing to work with you. Glad you got an appointment at Mayo and January is not that far away. I had Taxatere neoadjunctly and it really shrunk my tumor to almost nothing. I hope you have good results with the Taxatere.
__________________
Kate
Stage IIIC Diagnosed Oct 25, 2005 (age 58)
ER/PR-, HER2+++, grade 3, Ploidy/DNA index: Aneuploid/1.61, S-phase: 24.2%
Neoadjunct chemo: 4 A/C; 4 Taxatore
Bilateral mastectomy June 8, 2006
14 of 26 nodes positive
Herceptin June 22, 2006 - April 20, 2007
Radiation (X35) July 24-September 11, 2006
BRCA1/BRCA2 negative
Stage IV lung mets July 13, 2007 - TCH
Single brain met - August 6, 2007 -CyberKnife
Oct 2007 - clear brain MRI and lung mets shrinking.
March 2008 lung met progression, brain still clear - begin Tykerb/Xeloda/Ixempra
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11-28-2007, 08:09 PM
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#9
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Senior Member
Join Date: Sep 2006
Location: Houston, Texas
Posts: 624
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Good luck with your 2nd opinion and a good tx plan. I will be rooting for you.
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11-28-2007, 08:20 PM
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#10
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Senior Member
Join Date: Dec 2006
Posts: 136
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Michelle -
It is good to see you are ready to "duke it out". You sure seem to be your own great advocate for what your going through. I so hope Mayo can get your appt. moved up sooner. The waiting is so darn tough.
A big hug to you tonight.
__________________
Debra
Diag. 11/05 at age 40 triple positive
3.8 cm tumor and 9 mm tumor
Stage IIb/SN positive(no other nodes)Grade 3
Bilat. mastect. 12/05 (Rt.prophylactic) followed with AC/taxol/Herceptin/tamoxifen then switched to arimidex after hysterectomy in 12/06. August 07 switched to Aromasin due to severe jt. pain from Arimidex. Nov. 2011 No more meds and NED!
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11-28-2007, 08:32 PM
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#11
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Senior Member
Join Date: Jul 2007
Location: Northern California
Posts: 764
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Michelle,
I am glad you are ready to fight again. I'm praying for you as you begin this new battle.
Hugs
__________________
DX 02/01/07
2.5 cm, Er/Pr-, Her2+++
18/20 Nodes
03/07 CT & Bone scan - Clear
AC x 4, Taxol x 4, Added Herceptin
Radiation until 09/07
Herceptin every 3 weeks until 06/08
01/10/08 local recurrence -IBC
01/28/08 CT & Brain MRI - clear
02/08 - Navelbine & Herceptin
05/08 -MRM
05/08 - Gemzar & Herceptin - didn't work
09/08 - Hyperthermia rads
03/09 - Tykerb/Xeloda
05/10 - Tram flap to fix wound
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11-28-2007, 11:13 PM
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#12
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Senior Member
Join Date: Sep 2005
Posts: 232
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I am so happy that you have a plan and that you are feeling better.
Hugs,
Karen
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11-29-2007, 09:00 PM
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#13
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Senior Member
Join Date: Oct 2007
Posts: 1,851
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Michelle,
Your onc seems really willing to listen and work with you which is great.
I hope your appointment at Mayo gets moved up.
My prayers are with you.
__________________
Diagnosed stage 2b in July 2003 (2.3 cm, HER2+, ER-/PR-, 7+ nodes). Treated with mastectomy (with immediate DIEP flap reconstruction), AC + T/Herceptin (off label). Cancer advanced to lung in Jan. 2007 (1 cm nodule). Started Herceptin every 3 weeks. Lung wedge resection April 2007. Cancer recurred in lung April 2008. RFA of lung in August 2008. 2nd annual brain MRI in Oct. 2008 discovered 2.6 cm cystic tumor in left frontal lobe. Craniotomy Oct. 2008 (ER-/PR-/HER2-) followed by targeted radiation (IMRT). Coughing up blood Feb. 2009. Thoractomy July 2009 to cut out fungal ball of common soil fungus (aspergillus) that grew in the RFA cavity (most likely inhaled while gardening). No cancer, only fungus. Removal of tiny melanoma from upper left arm, plus sentinel lymph node biopsy in Feb. 2016. Guardant Health liquid biopsy in Feb. 2016 showed mutations in 4 subtypes of TP53. Repeat of Guardant Health biopsy in Jana. 2021 showed 3 TP53 mutations, BRCA1 mutation and CHEK2 mutation. Invitae genetic testing showed negative for all of these. Living with MBC since 2007. Stopped Herceptin Hylecta (injection) treatment in March 2020. Recent 2021 annual CT of chest, abdomen and pelvis and annual brain MRI showed NED. Praying for NED forever!!
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11-29-2007, 10:54 PM
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#14
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Senior Member
Join Date: Nov 2005
Location: Northern Calif.
Posts: 981
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Michelle,
Thinking about you. I am really hopeful that your new tx will kick cancer butt.
Hugs and Prayers,
Lexi
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11-30-2007, 12:54 AM
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#15
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Senior Member
Join Date: Aug 2007
Location: Detroit Metropolitan Area, Michigan
Posts: 592
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Michelle,
It seems you have a great oncologist to support you in finding all treatment possibilities for you. And you are knowledgeable which is the best amunition for fighting this disease.
May you remain strong, experience the best care and wellness,
__________________
Aug06...Dx Age 50, IDC Left Breast, 6+/16 lymph nodes, Stg 3, ER+/PR+/HER2+
Sep06-Jan07...Mediport. Chemo: AC x 4, T x 4
Dec06-Nov07...Herceptin
Feb12,2007...Surg MRM Left & SM Right, reconstruct w/expanders
Mar07-Jun07...Saline Exp
Jun07...Start Tamoxifen
Jun07-Aug07...Rad x 25
Jun07-Oct07...Persistent fevers-unknown origin
Jun07-Nov07...PT for Severe PMPS & Capsular Contracture
Nov07...Surg Capsulectomy, Gel Implants, PMPS pain gone instantly.
Feb08...NED 1st CANCERVERSARY!!!!!
Feb08...2 months post surgery Caps Cont again :(
Mar08...Stop Tamoxifen. Start Arimidex.
Apr08...Sudden high fever, Hosp ICU 10 days, staph infect, emerg surg, implants removed. Outpt IVantibiotics Daily x 6 weeks
Feb11...NED 5th CANCERVERSARY!!!!!
Feb12...NED 6th CANCERVERSARY!!!!!
Aug12...Spotting. Surg=D&C
Sep12...STAGE IV = RARE BC METS TO UTERUS ILC ER+/PR+/HER2-Negative) (Different BC than originally diagnosed = IDC ER+/PR+/HER2+).
Sep12...Stop Arimidex. Start Afinitor & Aromasin.
Jan13...MRI = no progression no reduction
Apr13...Progression. Stop Afinitor & Aromasin.
Apr13...Start Chemo: Taxol & Carboplatin.
Nov13...Scans & Pelvic 95+% Reduction. Nueropathy>Stop chemo start Fareston.
Jan14...PET scan = no progression stable.
May14...Pelvic > Bleeding & cramps. TMs up.
May14...PET scan = uterine progression :(
May14...Stop Fareston. Start Chemo: Xeloda.
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