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<DIR>Yes, there was a wonderful detailed post or two, somewhere... and some of which I'd saved in a 'safe' place... so safe I can't find it!
It has to do with moleculer Wgt. You can google a drug name+molecular wgt. and have some luck finding an answer. The 'limit' is around a high 300. So, technically, Xeloda is small enough to pass the bbb. And has for me, we think, in combo with the Temodar.
here is just a tiny bit of what I could find and other than Tykerb, I know of no others to be small enough:
GEMZAR : molecular wgt.= 299.66
TEMODAR : molecular wgt.= 194.15
XELODA : molecular wgt.= 359.35
then there's the disscussion of 'leaky' bbb caused by the tumor or radiation... allowing possibly other larger wgts to enter brain.
oh, I think one of the platinums has been used with some small success. But my brain is just 'leaky' and not sure ........phooey.
pattyz
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