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also perhaps an effect of vitamin D
clearly there is some "clock mechanism" as tumors tend to recur in peaks
a certain number of months after surgery (not after lumps discovered) and the certain number of months differs by tumor subtype, at least w her2neu
the initial peak occurs 24-36 months or so after surgery as I understand it.
Circadian rhythm research is not well funded and research on melatonin is not very advanced at present it seems....
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