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I saw the original study given by the researcher at ASCO 2006. Both the original presentation and the published results (read all the articles published on the board right now including the one on Articles of Interest posted by Mgarr (Mary)). Taxol gives benefit for all Her2+ patients REGARDLESS of hormone status. In the actual presentation of results, the difference in benefit between Her2+ patients that are hormone negative versus hormone positive was not significant, therefore the results of benefit are the same.
Because of seeing this paper firsthand, when Stage 1 women ask whether they should include taxol (as in the past many stage 1 women only receive 4 AC treatments followed by Herceptin), I have posted this original study stating, if given a choice, take the taxol too - it is the KEY ingredient.
Secondly - I believe this is why the TCH treatment works just as well as the AC followed by TH. It is the Taxol that is the more important chemo! More true research needs to be done to confirm this or more time needs to pass on current studies and long term results but I believe they will find that taxanes are key for Her2+ disease (regardless of hormone status) and for triple negative disease.
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Kind regards
Becky
Found lump via BSE
Diagnosed 8/04 at age 45
1.9cm tumor, ER+PR-, Her2 3+(rt side)
2 micromets to sentinel node
Stage 2A
left 3mm DCIS - low grade ER+PR+Her2 neg
lumpectomies 9/7/04
4DD AC followed by 4 DD taxol
Used Leukine instead of Neulasta
35 rads on right side only
4/05 started Tamoxifen
Started Herceptin 4 months after last Taxol due to
trial results and 2005 ASCO meeting & recommendations
Oophorectomy 8/05
Started Arimidex 9/05
Finished Herceptin (16 months) 9/06
Arimidex Only
Prolia every 6 months for osteopenia
NED 18 years!
Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"
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