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Old 07-22-2007, 01:39 PM   #1
tousled1
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Donna,

I'm elated to hear that Pat is doing better. Doxorubicin is Adriamycin. I had 4 rounds of Adriamycin when I was first diagnosed and had it neo-adjunctly (before surgery) to shrink my large tumor. My neo-adjunct chemo did it's job -- it shrunk my tumor to almost nothing. On this combo make sure that she gets frequent MUGAs or echocardiogrqams as it's hard on the heart. I'm praying that this combo will work for her. MIRACLES DO HAPPEN!

As for her depression - that's quite normal. I think that anyone who has cancer suffers from depression, some worse than others. You are doing a great job as her caregiver. Just be there for her, encourage her, and give her a shoulder to cry on.
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Kate
Stage IIIC Diagnosed Oct 25, 2005 (age 58)
ER/PR-, HER2+++, grade 3, Ploidy/DNA index: Aneuploid/1.61, S-phase: 24.2%
Neoadjunct chemo: 4 A/C; 4 Taxatore
Bilateral mastectomy June 8, 2006
14 of 26 nodes positive
Herceptin June 22, 2006 - April 20, 2007
Radiation (X35) July 24-September 11, 2006
BRCA1/BRCA2 negative
Stage IV lung mets July 13, 2007 - TCH
Single brain met - August 6, 2007 -CyberKnife
Oct 2007 - clear brain MRI and lung mets shrinking.
March 2008 lung met progression, brain still clear - begin Tykerb/Xeloda/Ixempra
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Old 07-22-2007, 03:46 PM   #2
Grace
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Donna and Pat,

So happy for you both. It will be wonderful if she can go home, and at home the depression may lift. Or perhaps she can take anti-depressants. I believe lots of women on this board do.

Really, really happy for you both.
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Old 07-22-2007, 05:28 PM   #3
hutchibk
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I got Dox/Adria my first round through chemo in 2004, with Taxotere and Cytoxan. It is also called BIG RED. In my book it is considered one of the Big Guns. I hope that the doc keeps a good watch on her heart with the combo of Adria and Herceptin, as both can be pretty hard on the heart, but not everyone has problems. Other than that, I am thrilled to hear that she is having such a speedy reaction to it!! I pray for you both that this lasts. Also, regarding her depression, being as sick as she has the last couple of weeks, it is no surprise that she would be depressed... accepting the inevitable and then deciding to agree to a last ditch effort that you are afraid to bank all your hopes on. I have been through that scenario a time or two, although I have never been as sick as it sounds like Pat was... all of my recurrances have been detected very early and have been very manageable. But I think all of us here know that depression and fear. I would ask her and her doc if an anti-depressant would be prudent at this time. If her depression takes hold, she may not have the fortitude necessary to see this new treatment through.
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Brenda

NOV 2012 - 9 yr anniversary
JULY 2012 - 7 yr anniversary stage IV (of 50...)

Nov'03~ dX stage 2B
Dec'03~
Rt side mastectomy, Her2+, ER/PR+, 10 nodes out, one node positive
Jan'04~
Taxotere/Adria/Cytoxan x 6, NED, no Rads, Tamox. 1 year, Arimadex 3 mo., NED 14 mo.
Sept'05~
micro mets lungs/chest nodes/underarm node, Switched to Aromasin, T/C/H x 7, NED 6 months - Herceptin only
Aug'06~
micro mets chest nodes, & bone spot @ C3 neck, Added Taxol to Herceptin
Feb'07~ Genetic testing, BRCA 1&2 neg

Apr'07~
MRI - two 9mm brain mets & 5 punctates, new left chest met, & small increase of bone spot C3 neck, Stopped Aromasin
May'07~
Started Tykerb/Xeloda, no WBR for now
June'07~
MRI - stable brain mets, no new mets, 9mm spots less enhanced, CA15.3 down 45.5 to 9.3 in 10 wks, Ty/Xel working magic!
Aug'07~
MRI - brain mets shrunk half, NO NEW BRAIN METS!!, TMs stable @ 9.2
Oct'07~
PET/CT & MRI show NED
Apr'08~
scans still show NED in the head, small bone spot on right iliac crest (rear pelvic bone)
Sept'08~
MRI shows activity in brain mets, completed 5 fractions/5 consecutive days of IMRT to zap the pesky buggers
Oct'08~
dropped Xeloda, switched to tri-weekly Herceptin in combo with Tykerb, extend to tri-monthly Zometa infusion
Dec'08~
Brain MRI- 4 spots reduced to punctate size, large spot shrunk by 3mm, CT of torso clear/pelvis spot stable
June'09~
new 3-4mm left cerrebellar spot zapped with IMRT targeted rads
Sept'09~
new 6mm & 1 cm spots in pituitary/optic chiasm area. Rx= 25 days of 3D conformal fractionated targeted IMRT to the tumors.
Oct'09~
25 days of low dose 3D conformal fractionated targeted IMRT to the bone mets spot on rt. iliac crest that have been watching for 2 years. Added daily Aromasin back into treatment regimen.
Apr'10~ Brain MRI clear! But, see new small spot on adrenal gland. Change from Aromasin back to Tamoxifen.
June'10~ Tumor markers (CA15.3) dropped from 37 to 23 after one month on Tamoxifen. Continue to monitor adrenal gland spot. Remain on Tykerb/Herceptin/Tamoxifen.
Nov'10~ Radiate positive mediastinal node that was pressing on recurrent laryngeal nerve, causing paralyzed larynx and a funny voice.
Jan'11~ MRI shows possible activity or perhaps just scar tissue/necrotic increase on 3 previously treated brain spots and a pituitary spot. 5 days of IMRT on 4 spots.
Feb'11~ Enrolled in T-DM1 EAP in Denver, first treatment March 25, 2011.
Mar'11~ Finally started T-DM1 EAP in Denver at Rocky Mountain Cancer Center/Rose on Mar. 25... hallelujah.

"I would rather be anecdotally alive than statistically dead."
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Old 07-22-2007, 06:21 PM   #4
Vanessa
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So glad to hear she is responding. Best wishes and I will continue to keep her in my prayers.
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Old 07-22-2007, 07:23 PM   #5
Karen Weixel
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What wonderful news!!

Karen
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Old 07-22-2007, 07:50 PM   #6
Bev
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Yeah! Good news is good for all of us. AC and H together can be rough on the heart. Time will eventually heal some of the depression. In the meantime meds like Zoloft help take the edge off. Ac is one of the big guns, but they're are more. Wow. So glad things turned around. Bev
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Old 07-22-2007, 08:24 PM   #7
chrisy
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Big guns?

hi Donna,
I, too, love to hear those miracle stories - and completely understand how you can hear good news and yet feel depressed. I've been there myself and it is very hard. It could very well be that Pat will walk on out of that hospital soon and keep going for a VERY LONG TIME! Good for her!

From her profile, I'd say there's already been some pretty heavy artillery in her arsenal. What a fighter. You're a good friend, Pat is lucky to have you.
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Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial

5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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