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04-19-2007, 01:24 AM
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#1
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Senior Member
Join Date: Nov 2006
Location: London, England
Posts: 96
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Herceptin given fast yesterday - is that ok?
I had Herceptin #9 yesterday, and unfortunately the drip chamber completely filled so the drip rate couldn't be seen. Almost all of it whooshed through in 25 minutes, instead of the usual hour and a half, before we noticed. I was reassured, by the experienced and very capable chemo nurse, that while this wasn't ideal, I needn't have any concerns over it.
Has this happened to anyone, and does anyone know of possible problems with this? My EF was checked 2 months ago, and had come down from 65% to 55%. I'm having another echo in 4 days' time. I felt okay yesterday, vaguely unwell in the evening, and woke in the night with my heart rate going a little fast. But this has happened before, and I didn't feel unduly worried.
I suppose my main concern is that having a larger than usual concentration might hit cardiac muscle a bit hard.
Caroline
__________________
Caroline
Diag. March 10th 2006, aged 46.
Invasive ductal carcinoma, 2cm + multifocal. Stage 2, Grade 3
HER2+++, ER+/PR+
Right mast. May 2006. 6 of 20 nodes positive
FEC x 4, taxotere x 4; port implanted after 6 cycles
Rads x 25
1 year of Herceptin ended Nov 07.
Arimidex 5 years
Considering reconstruction, maybe soon...
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04-19-2007, 04:00 AM
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#2
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Senior Member
Join Date: Aug 2006
Location: Sheboygan, WI
Posts: 2,582
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Hi Caroline,
Other than the loading dose of herceptin, which I received over an hour and a half's time, I received all the rest of my years worth of herceptin in 30 minutes time. I also received it every 3 weeks.
Have a wonderful day,
Mary Jo
__________________
"Be still and know that I am God." Psalm 46:10
Dx. 6/24/05 age 45 Right Breast IDC ER/PR. Neg., - Her2+++ RB Mast. - 7/28/05 - 4 cm. tumor Margins clear - 1 microscopic cell 1 sent. node No Vasucular Invasion 4 DD A/C - 4 DD Taxol & Herceptin 1 full year of Herceptin received every 3 weeks 28 rads prophylactic Mast. 3/2/06
17 Years NED
<>< Romans 8:28
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04-19-2007, 04:49 AM
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#3
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Senior Member
Join Date: Sep 2005
Location: Atlanta
Posts: 87
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Q3week Herceptin -30mins or 90 mins?
I don't think you have anything to worry about, Caroline.
I wish I could get my q3week Herceptin dose in 30mins!!
At the previous onc I was seeing, my Herceptin infusions were always only 30mins-whether it was a weekly dose or the q3week dose.
Since I've moved to a different doc & treatment center, their policy is to run the q3week dose in 90 mins. I try & try to get convince them to run the infusion rate a little faster, but no luck.
So now I just make sure to bring my laptop or a book & extra money for parking! I will say that when my infusions were faster, I did have more flu'ey side effects within the first 24 hours after the infusion. With the 90 min infusion, I don't.
However, I have been meaning to poll the ladies here & inquire how many folks on q3week Herceptin get their infuion in 30 mins vs. 90?
Take good care &
Keep the Faith!
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04-19-2007, 07:53 AM
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#4
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Senior Member
Join Date: Aug 2006
Posts: 3,380
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Mine are always 90 minutes.
Hopeful
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04-19-2007, 07:58 AM
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#5
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Senior Member
Join Date: Jan 2007
Posts: 144
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Mine are always 90 minutes. Wish they were 30!
Emelie
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04-19-2007, 10:09 AM
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#6
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Senior Member
Join Date: Aug 2003
Location: Morris, IL
Posts: 3,507
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Other than the loading dose, mine have been 30 minutes every 3 weeks for almost 4 years. I have never had a problem, no premeds, not even with the loading dose.
__________________
"Be kinder than necessary, for everyone you meet is fighting some kind of battle."
Hugs & Blessings
Sheila
Diagnosed at age 49.99999 2/21/2002 via Mammography (Calcifications)
Core Biopsy 2/22/02
L. Mastectomy 2/25/2002
Stage 1, 0.7cm IDC, Node Neg from 19 nodes Her2+++ ER PR Neg
6/2003 Reconstruction W/ Tissue Expander, Silicone Implant
9/2003 Stage IV with Mets to Supraclavicular nodes
9/2003 Began Herceptin every 3 weeks
3/2006 Xeloda 2500mg/Herceptin for recurrence to neck nodes
3/2007 Added back the Xeloda with Herceptin for continued mets to nodes
5/2007 Taken Off Xeloda, no longer working
6/14/07 Taxol/Herceptin/Avastin
3/26 - 5/28/08 Taxol Holiday Whopeeeeeeeee
5/29 2008 Back on Taxol w Herceptin q 2 weeks
4/2009 Progression on Taxol & Paralyzed L Vocal Cord from Nodes Pressing on Nerve
5/2009 Begin Rx with Navelbine/Herceptin
11/09 Progression on Navelbine
Fought for and started Tykerb/Herceptin...nodes are melting!!!!!
2/2010 Back to Avastin/Herceptin
5/2010 Switched to Metronomic Chemo with Herceptin...Cytoxan and Methotrexate
Pericardial Window Surgery to Drain Pericardial Effusion
7/2010 Back to walking a mile a day...YEAH!!!!
9/2010 Nodes are back with a vengence in neck
Qualified for TDM-1 EAP
10/6/10 Begin my miracle drug, TDM-1
Mixed response, shrinking internal nodes, progression skin mets after 3 treatments
12/6/10 Started Halaven (Eribulen) /Herceptin excellent results in 2 treatments
2/2011 I CELEBRATE my 9 YEAR MARK!!!!!!!!!!!!!
7/5/11 begin Gemzar /Herceptin for node progression
2/8/2012 Gemzar stopped, Continue Herceptin
2/20/2012 Begin Tomo Radiation to Neck Nodes
2/21/2012 I CELEBRATE 10 YEARS
5/12/2012 BeganTaxotere/ Herceptin is my next miracle for new node progression
6/28/12 Stopped Taxotere due to pregression, Started Perjeta/Herceptin
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04-19-2007, 11:16 AM
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#7
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Senior Member
Join Date: Aug 2006
Location: Rowlett, TX
Posts: 138
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Mine are always 90 minutes for the 3-week dose.
__________________
Janet in Rowlett Texas
Dx July 2006 IDC 1.8cm, ER-/PR- HER2+ (FISH 7), KI67 High (60%) grade 3, TOPO II neg
Aug2006: lumpectomy, SNB (4 nodes neg), Stage 1
Jan 2007: Finished 6 cycles of TCH (Taxotere, Carboplatin, Her ceptin). Then Herceptin every 3 weeks.
Feb 2007: Completed Radiation
May 2007: Stopped Herceptin due to low LVEF (49%)
July 2007: LVEF now 44% -- starting Coreg
May 2008: Heart NORMAL! Yippee.
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04-19-2007, 11:28 AM
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#8
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Member
Join Date: Sep 2006
Posts: 10
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I also have received the Herceptin for 30 minutes for nearly 5 years and I have received it at various times once every 3 weeks, once every other week and 3 weeks on and 1 week off all depending on the accompaning chemo.
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04-19-2007, 11:33 AM
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#9
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Senior Member
Join Date: Jan 2006
Posts: 58
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Mine is infused in 30 mins.
I get Herceptin every 3 weeks. I've had no problems with the faster infusion time. My onc was originally on the 90-minute regimen, but I asked him if we could condense that, so we went to 1 hr the following time, and after that it's been 30 mins. Love it!
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04-19-2007, 12:13 PM
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#10
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Senior Member
Join Date: Mar 2006
Location: IOWA
Posts: 243
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My every three week infusions were always 30 minutes.
__________________
Andi
-- ------------------------
Stage IIIC, 17 of 20 Nodes +, E+, Her2+++
Diagnosed 6/30/05
Lumpectomy 7/13/05
Dose Dense A/C x 4
Weekly Taxol + Herceptin x 12
Remainder of year Herceptin Every 3 weeks (completes 9/13/06)
Radiation completed 2/28/06
Currently on Tamoxifen
Dec 06 - Pleural effusion treated with pleurodesis
Now er/pr-, her2++
1/07 started weekly Navelbine plus Herceptin
Discontinued Tamoxifen
4/27/07 CTshowed progression
5/01/07 Began Tykerb/Xeloda + Zometa
5/22/07 Stopped treatment due to great progression
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04-19-2007, 12:50 PM
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#11
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Senior Member
Join Date: Feb 2007
Posts: 108
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Just to be the odd-ball, mine are always 45 minutes....split the difference!
__________________
Age 50, premenopausal
Dx 1/2/07 DCIS/IDC
Lumpectomy 1/4/07 1.1cm tumor
SNB 3 nodes clear
Stage 1, Grade 2, HER2+++ (FISH 6.8)
ER + / PR +
TCH, 6 rounds, finished 6/1/07!!!
Herceptin to continue for 1 year
36 rads finished 8/22/07
Port out 8/27/07
Switched to Herceptin weekly for joint pain
Ooph 11/13/07
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04-19-2007, 07:41 PM
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#12
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Senior Member
Join Date: Oct 2005
Location: New Jersey
Posts: 3,154
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Mine are always 90 min. every 3 wks. Nearing the end of herceptin 
Jean
__________________
Stage 1, Grade 1, 3/30/05
Lumpectomy 4/15/05 - 6MM IDC
Node Neg. (Sentinel node)
ER+ 90% / PR-, Her2+++ by FISH
Ki-67 40%
Arimidex 5/05
Radiation 32 trt, 5/30/05
Oncotype DX test 4/17/06, 31% high risk
TOPO 11 neg. 4/06
Stopped Arimidex 5/06
TCH 5/06, 6 treatments
Herceptin 5/06 - for 1 yr.
9/06 Completed chemo
Started Femara Sept. 2006
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04-19-2007, 08:39 PM
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#13
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Senior Member
Join Date: Jan 2007
Posts: 138
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Mine was always 90 minutes, every three weeks.
I don't think you have anything to worry about.
Karen
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04-19-2007, 09:11 PM
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#14
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Senior Member
Join Date: May 2006
Location: California
Posts: 668
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You are ok!
Don't worry, if you were to have any problems they would have manifested right away. I'm not an expert on this area, but according to the many nurses I have seen over the last 14 years, you are going to be just fine!!! Take care.
I agree with the other sister, I wish mine were also short, like 30 mins. max...but well if I have to wait 90 minutes; I will wait 90 minutes. I always bring lots of books to read....Keep us posted, please....
__________________
1994 - rt brst, .lump, underarm node dissection,chemo+rad 1.2 cms, Grade 3.
28 nodes neg
Er,Pr, Positive HER2 status unknown
2003- Recur to rt lung.July 16 ( B-Day!)
Her2+++ Er,Pr, Negative
2003 - Aug04--Navelbine + Herceptin
2004- 2007--NED - Herceptin, only
2007 Feb-April Xeloda added to hereceptin
2007-May Back on Navelbine+Herceptin
2008-Feb-Mar 15 Ses Rad to Rt. Lung
2008- Oc 17 Add Tykerb to Herceptin
2009- June-- Discont Tykerb
2009 July 7--Current Taxol + Herceptin
2009 Dec--Discontinued treatment due to progression. Looking into cyberknife.
2010-Aug Accepted to TDM1, no SE, except liver count went up.
2010-2011 September got kicked out of the trial, due to a small spot found on lung.
2011- 2012 September thru early 2013 on Herceptin
2013- March Bone density shows small spot on 5th rib.
2013 - April 4th appt with onc. will post after discussing course of treatment.
2013-March-April Cyber knife to brain and radiation to rib. Chest --base line before chemo-CT-Scan stable for lung issue. CA2729 Normal.
2013 April Herceptin- TDMI
2013 Sept Herceptin + Perjeta . CA2729 within normal range. Brain and Pet scans October 31st. will post results.
2013 October Brain MRI- mixed response. Will see Onc/rad on Halloween.
2013 October/November Brain-MRI nothing new. Repeat MRI next year in May.
2013 December Continue Herceptin and Perjeta. Stable at the moment.
2014 February Brain MRI -clear!
2014 January Added Taxotere to Perjeta+Herceptin.
2014 March Stopped chemo-chest ct-scan next.
2014- March Scans shows tumor's larger, CA2729 higher. Discontinue Herceptin.
2014 April Perjeta+ Halaven
2014 April CA2729 went down 60 points after one cycle. Cough does not want to go away.
2014 June Continue on Perjeta + Halaven-- no more cough. Stable
2014 June Back on Herceptin + abraxane
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04-20-2007, 01:03 PM
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#15
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Senior Member
Join Date: Nov 2006
Location: London, England
Posts: 96
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Feeling fine
Hi everyone
I had no idea it was standard in some centres to give it that fast. I was amazed to hear that so many of you get your Herceptin in 30 minutes, and greatly reassured.
That's why I love this site so much!
Love and best wishes to all
Caroline
__________________
Caroline
Diag. March 10th 2006, aged 46.
Invasive ductal carcinoma, 2cm + multifocal. Stage 2, Grade 3
HER2+++, ER+/PR+
Right mast. May 2006. 6 of 20 nodes positive
FEC x 4, taxotere x 4; port implanted after 6 cycles
Rads x 25
1 year of Herceptin ended Nov 07.
Arimidex 5 years
Considering reconstruction, maybe soon...
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