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03-14-2007, 09:52 AM
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#1
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Senior Member
Join Date: Feb 2007
Location: Suwanee, Georgia.
Posts: 56
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I was told that Herceptin will only last about 9 months after taken with Taxol. 9 months later it has returned? Why don't they tell you this information before receiving the treatment?
__________________
1/2002 DX stage IIa IDC er/pr+ her2 3+ positive: insitu ductal carcinoma right breast, 3cm 8 node removal all neg;lumpectomy;4 rounds A/C; 33 rads
tamoxifen
4/2004 DX Local Reacurrance; er/pr+ her2 3+ positive; nodes 9 of 12 positive largest 1.5 cm; 28 rads;stopped tamoxifen;went on Femara/lupron
8/2004 DX Local Reacurrance; er/pr+ her2 3+ positive; dbl mas reconstructive surgery w/tran flap; no chemo or drugs
11/2005 DX Local Reacurrance; er/pr+ her2 3+ positive; Taxol/Herceptin 1x weekly for 12 weeks; Herceptin for 9 months 1x 21 days
12/2006 DX Local Reacurrance; er/pr- her2 3+ positive; Her 2 rechecked with FISH her2+++ er/pr-
3/9/07 Started Tykerb (Lapatinib) 1250 mg/once daily
Xeloda (Capecitabine 2000 mg/m2/daily 1-14 every 21 days
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03-14-2007, 03:46 PM
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#2
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Senior Member
Join Date: Sep 2005
Location: South Dakota.
Posts: 621
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Is it in reference to metestatic breast cancer?
The sentence that you highlighted in red, is one that I also have highlighted (from the "volumes" of information that I make copies of) from an article with the same quote, some time ago. I wondered what that meant, too. Is this statement referring to metestatic breast cancer?
__________________
Blessings and Peace,
Barbara
DX Oct 02 @ age 52 Stage 2B Grade 3 Mastectomy
"at least" 4.5 cm IDC 1+node ER+61% /PR-
Assiciated Intraductual component with Comedo Necrosis
Her2+ FISH8.6 IHC 2+
5 1/2 CEF Arimidex
Celebrex 400mg daily for 13 months
Prophylactic mastectomy
Estradiol #: 13
PTEN positive, "late" Herceptin (26 months after chemo)
Oct 05: Actonel for osteopenia from Arimidex.
May 08: Replaced Actonel with Zometa . Taking every 6
months.
Accepting the gift of life, I give thanks for it and live it in fullness.
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03-14-2007, 06:52 PM
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#3
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Senior Member
Join Date: Oct 2005
Location: New Jersey
Posts: 3,154
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Becky,
is out of town on business and will return at end of week.
She does not have access to computer.
Jean
__________________
Stage 1, Grade 1, 3/30/05
Lumpectomy 4/15/05 - 6MM IDC
Node Neg. (Sentinel node)
ER+ 90% / PR-, Her2+++ by FISH
Ki-67 40%
Arimidex 5/05
Radiation 32 trt, 5/30/05
Oncotype DX test 4/17/06, 31% high risk
TOPO 11 neg. 4/06
Stopped Arimidex 5/06
TCH 5/06, 6 treatments
Herceptin 5/06 - for 1 yr.
9/06 Completed chemo
Started Femara Sept. 2006
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03-14-2007, 07:32 PM
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#4
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Senior Member
Join Date: Aug 2006
Posts: 3,380
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Maryls,
Here is a link to a recent article which states that Herceptin is cost effective, given the improved survival time of patients: http://www.medscape.com/viewarticle/553595
Here is a pertinent excerpt:
The 2 studies differed in 2 key areas — the duration of trastuzumab's benefit<sup> </sup>and the annual risk for systemic recurrence. In the study led by Nicola Lucio Liberato, MD, from the Azienda Ospedaliera della Provincia di Pavia, Ospedale Civile, Italy, they assumed that the benefit of trastuzumab would persist<sup> </sup>only for 5 years — a notion that is well supported by the Early Breast Cancer<sup> </sup>Trialists' Meta-Analysis.
In contrast, in the study led by Allison Kurian, MD, from the Veterans' Affairs Palo Alto Health Care System and Center for Primary Care and Outcomes Research at Stanford University, in California, they assumed a one-third decline in benefit in years 3 to 5 and<sup> </sup>an additional but persistent benefit from years 6 to 10. In their editorial, Drs. Hillner and Smith call these numbers "excessively optimistic." The reports also differed slightly<sup> </sup>in the risk for systemic recurrences beyond 5 years, but this<sup> </sup>had little impact on the results.
Hope this information is useful.
Hopeful<sup> </sup>
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03-14-2007, 08:04 PM
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#5
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Senior Member
Join Date: Oct 2005
Location: Boise, Idaho
Posts: 758
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I guess if I had stopped to really think this out I would have realized that it probably is not referring to those of us who were stage 1 who received Herceptin after the 2005 ASCO released the news about the trials. Mainly because no one is following up on us as if we were in a trial. I will continue with my head in the clouds and my ears to the ground until my body tells me otherwise. Hopeful, thanks for your input. I subscribe to Medscape for Nurses as I am one(old & retired but they don't care.)
Love & hugs,
Marlys
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03-14-2007, 08:55 PM
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#6
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Senior Member
Join Date: May 2006
Location: northshore suburb of chicago
Posts: 1,093
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That underlined red sentence can make you crazy. According to that, her2 people are doomed no matter the herceptin. Can't believe that.
__________________
~Rina~
Dx:3/06 had a lumpectomy April 19, 2006
Her2+ er/pr- Stage I Grade 3 tumor size 1.4 cm, node negative
AC 4 dense doses
34 radiation treatments including booster doses
receiving herceptin every 3 weeks since late August 2006 for 12 months
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03-14-2007, 09:12 PM
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#7
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Senior Member
Join Date: Sep 2005
Location: Atlanta
Posts: 87
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a matter of semantics...
"Disease progression" is NOT synonymous w "DEATH SENTENCE"
Many of us here have beat back disease that has "progressed" multiple times, and lived to tell about it!
Thank God for Tykerb & all the other great drugs on the horizon to keep us surviving & THRIVING!
Keep the Faith~
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