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Old 03-11-2007, 10:29 PM   #1
CSheley
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Join Date: Nov 2006
Posts: 4
Hi Holly!

I just stopped Xeloda due to the side affects and because my cancer continued to progress. My hands are still peeling from the burning sensation and I've had two ingrown toe nails due to the brittle affects on the nails. The worseFrom what I've read, however, my dosage seemed high -- 2,500 in the morning and 2,000 at night for one week then off a week and then repeat. My oncologist reduced the morning dosage to 2000 and that helped.

When the side affects got worse again, I actually felt like I was walking on a bed of sharp nails or on broken glass. We were going to reduce the doage again but due to cancer progression we stopped it completely. I was worried that there were not a lot of other options but my oncologist encouraged me that there are more drug combinations and we'll keep trying until one works.

Someone on this site suggested Balmex, a diaper rash cream. I tried several other creams and lotions but the Balmex worked best for me. Eurcern Calming Cream helped the feet at night. I also used cuticle oil which helped the nails. I did not connect the ingrown toe nails until just recent when the second one occurred within 4 weeks of the other and I've never had any problems before.

This is a great site and I've been a silent visitor for a long time. I pray that the Xeloda works well for you with very little side affects.

Carolyn
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Old 03-12-2007, 10:17 AM   #2
holly422
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Join Date: Mar 2007
Location: Shadyside, Ohio
Posts: 10
Hello everyone. Well it's Monday morning and I just took my first dose of Xeloda. I called my oncologist to see if the 4,000 mg a day was too much along with two weeks on and one week off, but he is going to try this first. I go for Herceptin on Thursday, so then I can talk to him face to face and tell him that I think that 4,000 mg seems like alot and that one week on and one week off should be better. Thanks to all of you!
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Old 03-12-2007, 03:20 PM   #3
Sheila
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Join Date: Aug 2003
Location: Morris, IL
Posts: 3,507
Holly

Xeloda is given according to body weight...but the latest reports show that 2500 mg a day in 2 divided dosed is just as good and performs as well as the 4000mg dose. The standard of care is 14 days on, 7 off then blood tests to make sure your red blood counts stay up. I have never had a problem with counts.....maybe if you talk to your onc. he/she will change their mind. This was brought up back in Dec. at the San Antonio BC Symposium....I wish I could find the abstract. I do think you need to take it 14 on and 7 off....that is the norm, although some people are on smaller doses and take it continuously.
Hope this helps
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Sheila
Diagnosed at age 49.99999 2/21/2002 via Mammography (Calcifications)
Core Biopsy 2/22/02
L. Mastectomy 2/25/2002
Stage 1, 0.7cm IDC, Node Neg from 19 nodes Her2+++ ER PR Neg
6/2003 Reconstruction W/ Tissue Expander, Silicone Implant
9/2003 Stage IV with Mets to Supraclavicular nodes
9/2003 Began Herceptin every 3 weeks
3/2006 Xeloda 2500mg/Herceptin for recurrence to neck nodes
3/2007 Added back the Xeloda with Herceptin for continued mets to nodes
5/2007 Taken Off Xeloda, no longer working
6/14/07 Taxol/Herceptin/Avastin
3/26 - 5/28/08 Taxol Holiday Whopeeeeeeeee
5/29 2008 Back on Taxol w Herceptin q 2 weeks
4/2009 Progression on Taxol & Paralyzed L Vocal Cord from Nodes Pressing on Nerve
5/2009 Begin Rx with Navelbine/Herceptin
11/09 Progression on Navelbine
Fought for and started Tykerb/Herceptin...nodes are melting!!!!!
2/2010 Back to Avastin/Herceptin
5/2010 Switched to Metronomic Chemo with Herceptin...Cytoxan and Methotrexate
Pericardial Window Surgery to Drain Pericardial Effusion
7/2010 Back to walking a mile a day...YEAH!!!!
9/2010 Nodes are back with a vengence in neck
Qualified for TDM-1 EAP
10/6/10 Begin my miracle drug, TDM-1
Mixed response, shrinking internal nodes, progression skin mets after 3 treatments
12/6/10 Started Halaven (Eribulen) /Herceptin excellent results in 2 treatments
2/2011 I CELEBRATE my 9 YEAR MARK!!!!!!!!!!!!!
7/5/11 begin Gemzar /Herceptin for node progression
2/8/2012 Gemzar stopped, Continue Herceptin
2/20/2012 Begin Tomo Radiation to Neck Nodes
2/21/2012 I CELEBRATE 10 YEARS
5/12/2012 BeganTaxotere/ Herceptin is my next miracle for new node progression
6/28/12 Stopped Taxotere due to pregression, Started Perjeta/Herceptin
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Old 08-12-2007, 05:33 PM   #4
ELLE
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Join Date: Jun 2007
Posts: 4
I Would Like To Share The Following Info.- From Personal Experience- While On Xeloda And Tykerb-for Skin Dryness & Peeling On Hands- Gold Bond Ultimate Healing Lotion Is Fantastic* It Is Inexpensive-very Thick & Non-greasy-you Can Find It At Most Drug Stores. Elle
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