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Old 02-01-2007, 05:26 PM   #1
Angela
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Join Date: Apr 2006
Location: North Carolina
Posts: 45
Question beta blocker for herceptin

I went to my cardiologist yesterday due to a drop in my muga. After chemo (a/c) in 2003 my heart function was at 60. Prior to starting hercepting Jan 12th of this year they did a mugs and it had dropped to 50.7. My cardiologist put me on Coreg, a beta blocker. He said that there has been a study that showed over 1/2 the people taking Coreg had no decreased function in their heart. Has anyone else heard of this or been put on a beta blocker?

I called my oncologist and asked it I should take it and he said yes. The cardiologist is still going to do an echo and treatmill to make sure we aren't missing something. I was just shocked to have dropped almost 10 points without being on any chemo or herceptin. At 42 years old my heart should be functioning much better then 50.7%
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Angela - NC

Dx May 2003 at age 39
Lt mastectomy, no nodes
DCIS, PR- ER- Her+++
4 rounds AC
Recurrence Dec 2006 Rt lung
2/07 - 3 Brain mets - Radiation
3/07 -
Carboplatin and Herceptin
8/07- mets stable. Finished Carboplatin-remain on Herceptin
12/07 - Herceptin only
5/08 - Lung mets grew - tykerb and Navilbene. Reaction to Tykerb -9/08 Herceptin again
12/08 - Lung mets growing - xeloda.
8/09 - Given Zometa for precaution
10/09 - Lung mets back plus new ones. - Put back on Xeloda.
1/10 – Began short-term disability

2/10 –Lung mets growing - Gemzar
9/2010 – Scan show tumors in lungs growing. Put on Ixempra (every 3 weeks). MRI of the brain showed a brain bleed but it had stopped bleeding.


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Old 02-01-2007, 09:09 PM   #2
Grace
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For what it's worth!

In March 2006,I had an echo doppler, and my lvef was 68%. When I went for my first MUGA before herceptin or any chemo, it was 59%, almost a ten percent drop. My next MUGA, three months later after herceptin, was 64%. The radiologist said I might have been under great stress when I got the 59% reading. And it's true, I was under stress during the first MUGA as the technicians had a difficult time finding my veins for the two injections. Were you under any particular stress? Sorry for your worry!
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Old 02-02-2007, 05:45 AM   #3
Angela
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Join Date: Apr 2006
Location: North Carolina
Posts: 45
With the reoccurence dx, I had the muga and bone scan on the same day and had to go back the next day for a pet scan, yes, I was under a lot of stress. They had told me that from the cat scan it was in my rt lung and my bones. But it was only in my lung...thank God.

Thanks for the information. I am hoping it was an incorrect reading and that when they do the echo it will be much higher.
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Hugs and Smiles,
Angela - NC

Dx May 2003 at age 39
Lt mastectomy, no nodes
DCIS, PR- ER- Her+++
4 rounds AC
Recurrence Dec 2006 Rt lung
2/07 - 3 Brain mets - Radiation
3/07 -
Carboplatin and Herceptin
8/07- mets stable. Finished Carboplatin-remain on Herceptin
12/07 - Herceptin only
5/08 - Lung mets grew - tykerb and Navilbene. Reaction to Tykerb -9/08 Herceptin again
12/08 - Lung mets growing - xeloda.
8/09 - Given Zometa for precaution
10/09 - Lung mets back plus new ones. - Put back on Xeloda.
1/10 – Began short-term disability

2/10 –Lung mets growing - Gemzar
9/2010 – Scan show tumors in lungs growing. Put on Ixempra (every 3 weeks). MRI of the brain showed a brain bleed but it had stopped bleeding.


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Old 02-02-2007, 08:39 AM   #4
Grace
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One other thought . . .

This weekend I was doing some research for a friend who had an unusually high lvef of 82%. I found in my research that people with thyroid (in her case, low) can have high and low readings. I also read a response by a cardiologist to a woman whose lvef had gone down to 50% after chemotherapy and was concerned. He was very upbeat about the reading,stating that readings can vary by 4/5 points and that he's seen those with 10% readings that lead good lives. In other words, he was telling her not to worry. If I can find that site again, I will post it for you.
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Old 02-02-2007, 11:50 AM   #5
MJo
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Join Date: Apr 2006
Location: Wilmington, Del.
Posts: 1,126
My LVEF went from 70 to 54 in my year of treatment. A woman in my group was down to 48 by the time she finished Herc in September. She was concerned enough to see a cardiologist who gave her another muga last week. It was 57. I am encouraged that my LVEF can recover too.
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IDC, Stage I, Grade 2
Oncotype DX Score 32
Her2++ E+P+, Node Neg.
Lumpectomy 11/04/05 Clear Margins
3 Dose dense AC (Couldn't tolerate 4)
4 Dose dense Taxol & Herc. (Tolerated well)
36 weeks Herceptin (Could not complete one year due to decrease in MUGA score)
2 years of Arimidex, then three years of Femara
Finished Femara May 2011
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