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Dear Jean
I was always under the impression that there are no extra (or more) Her2 or other receptors, its just that they talk to each other since the hormone receptors are out of commission (that is what the "resistance" is but it is a misnomer. It is implying that the anti-hormonal isn't working when it probably is but other forces are causing the cancer to grow).
Theoretically, the Bayer Her2 serum test should work. If cancer is present, growing and reproducing, it would be shedding the extra cellular domain (I am just talking out loud here - maybe Lani or Heblaj01 can comment).
Real resistance might be if one knew that they were only hormone positive and the drug failed to work at all (estrogen was still high or one could later test to see if tamoxifen didn't cover the receptors).
I hope I helped you alittle bit.
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Kind regards
Becky
Found lump via BSE
Diagnosed 8/04 at age 45
1.9cm tumor, ER+PR-, Her2 3+(rt side)
2 micromets to sentinel node
Stage 2A
left 3mm DCIS - low grade ER+PR+Her2 neg
lumpectomies 9/7/04
4DD AC followed by 4 DD taxol
Used Leukine instead of Neulasta
35 rads on right side only
4/05 started Tamoxifen
Started Herceptin 4 months after last Taxol due to
trial results and 2005 ASCO meeting & recommendations
Oophorectomy 8/05
Started Arimidex 9/05
Finished Herceptin (16 months) 9/06
Arimidex Only
Prolia every 6 months for osteopenia
NED 18 years!
Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"
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Hybrid Mode
