Endocrine Response Enhanced in ER+/PR+ Tumors

[Hopeful]

Here is the link: http://jcp.bmj.com/cgi/content/full/58/6/611 The title is "Association between tumour characteristics and HER-2/neu by immunohistochemistry in 1362 women with primary operable breast cancer."

The authors evaluated 1362 women from 2000-2003 in a single hospital in Belgium. The statistics they generated are very interesting. They concluded : "In women with ER+ tumours, the expression of PR affects the likelihood of HER-2/neu overexpression, and it may be that women with ER+ PR– tumours should be targeted with more aggressive treatment than those with ER+ PR+ tumours."

Hope this helps,

Hopeful

[Hopeful]

After a bit of digging, it surfaced. From May, 2003, titled: Progesterone receptor status significantly improves outcome prediction over estrogen receptor status alone for adjuvant endocrine therapy in two large breast cancer databases.

Here is the link: http://www.jco.org/cgi/content/full/21/10/1973

Hope this is helpful.

Hopeful

[Becky]

Dear Hopeful


Thank you so much as I did not read that article. Of course it is best to be hormone positive on both fronts but at least being ER+ (even if PR-) is better than nothing.

I really appreciate your help.

Have a wonderful Thanksgiving (assuming you are from the USA)