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Old 09-28-2006, 06:26 PM   #2
heblaj01
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Join Date: Apr 2006
Posts: 543
One of the other PI3K inhibitors that Dr Dihua Yu is alluding to may be the experimental drug SF1126 being considered also at MD Anderson for clinical trial:

http://www.semaforepharma.com/pdf/AARC_040406_FINAL.pdf

NEW DATA PRESENTED AT AACR MEETING FURTHER SUPPORT THE ADVANCE OF SEMAFORE’S TARGETED PI3K INHIBITOR INTO PHASE l TRIALS

--Studies at M.D. Anderson Show First In Vivo FDG-PET Imaging of SF1126 and Demonstrate Mutational Activation of PI3K as a Potential Marker for Selection of Patients—


However in a detailed discussion in the following article of the mode of action of some of the PI3K inhibitors some of their potential serious side effects are considered :

http://www.pubmedcentral.gov/articlerender.fcgi?artid=1236693

The survival kinases Akt and Pim as potential pharmacological targets




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