hypercoagulability awaken dormant tumor cells

[RobinP]

Hi Becky, nice to see your very happy photo today!

I am not sure that omega threes have a direct impact on thrombin but I do know they promote blood thinning to some extent. In fact, I THINK I read that omega threes act on preventing aggregate platelets, not on decreasing thrombin. Anyway, I like your "slippery slide by cancer theory" on omega threes. Pour on the omega3s and let's slide away from cancer-ha, ha.


PS. I also wonder why there are conflicting reports on vit e. Some say it does help prevent cancer spread, other don't. It's very confusing. It's also confusing that vit e may be a blood thinner and antioxidant yet has these conflicting reports. I also don't know why I was told by the Sloan that natural blood thiners may promote mets when so many articles that I googled today deny that.

[heblaj01]

Robin,

Your post remind me of an article by a internet medical commentator (but one without any medical background) who claimed that a big study of 5 or 6 touthands people taking blood thinners there was about 150 cancer patients among them but not a single metastatic case. Since he was not providing his source I was not able to check it.
He explained this unexpected lack of progression to metastasis by stating that the increased fluidity of the blood was preventing circulating cancer cells from sticking into narrow capillaries for the required 20 minutes he claimed was necessary for the cells to establish a permanent "foothold" to grow.
At the time I read it this seemed to me a bit outlandish but there is perhaps some valid elements in that theory?

[Lani]

the breast cancer gene profile by Affymetrix multigene array is remarkably similar to that of wound healing (which involves inflammation)

Of course the first step in wound healing is to stop bleeding

Perhaps this may be related to prostaglandins once again

Fortunately NSAIDs are both antiinflammatory and decrease platelet aggregation...so they may have several beneficial effects

There are many possible explanations. This is obviously an area in need of further research.

[R.B.]

Yes omega three and six have roles here through the eicosanoid.

Omega three and six each have their own families of thromboxanes.

It is Not an area I have specifically read up on, but IF it follows the pattern in very genereral terms omega six will provide the emergency high power functions and omega three the gentler long term repair solutions.


RB




From Wikipedia, the free encyclopedia
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Thromboxane is a member of the family of lipids known as eicosanoids. It is produced in platelets by thromboxane-A synthase, which is produced from the endoperoxides by the cyclooxygenase (COX) enzyme from arachidonic acid.
Enzymes and substrates associated with thromoboxane and prostacyclin synthesis.
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Enzymes and substrates associated with thromoboxane and prostacyclin synthesis.

Thromboxane is a vasoconstrictor and a potent hypertensive agent, and it facilitates the clumping of platelets. It is in homeostatic balance in the circulatory system with prostacyclin, a related compound. The widely used drug aspirin acts by inhibiting the ability of the COX enzyme to synthesize the precursors of thromboxane within platelets.

Thromboxane is named for its role in clot formation (thrombosis). Thromboxane A2 (TXA2), produced by activated platelets, has prothrombotic properties, stimulating activiation of new platelets as well as increasing platelet aggregation. Platelet aggregation is achieved by mediating expression of the glycoprotein complex GP IIb/IIIa in the cell membrane of platelets. Circulating fibrinogen binds these receptors on adjacent platelets, further strengthening the clot.

It is believed that the vasoconstriction caused by thromboxanes plays a role in Prinzmetal's angina.

[angelwings]

thanks for the very interesting article. the other time, i read something similar to this one here and after reading this article, i find myself in deep thoughts. i will print it and keep for later reference. thanks