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Re: Lapatinib + Xeloda = any hope?
I haven't tried this combo yet...but I was just down to UCLA to see about a phase III clinical trial that compares T-DM1 vs Tykerb/Xeloda. So I am sure it is a good treatment option or they wouldn't run it up against T-DM1. (That's my thoughts on it.) I also know of one woman that told me Tykerb/Xeloda worked great for her and has her back to NED/stable.
As far as tumor markers many oncologist don't like to use them. They aren't always reliable. However they are a very reliable tool for many of us...including my self. My onc runs the CA27.29 and the only time it went up is when I recurred. Then dropped when chemo proved to be working. So for me personally tumor markers work great. Tumor markers should be used as one part of the picture. If scans show progression and markers rise together...chances are you know they work for you. Hope this helps.
Chelee
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DX: 12-20-05 - Stage IIIA, Her2/Neu, 3+++,Er & Pr weakly positive, 5 of 16 pos nodes.
Rt. MRM on 1-3-06 -- No Rads due to compromised lungs.
Chemo started 2-7-06 -- TCH - - Finished 6-12-06
Finished yr of wkly herceptin 3-19-07
3-15-07 Lt side prophylactic simple mastectomy. -- Ooph 4-05-07
9-21-09 PET/CT "Recurrence" to Rt. axllia, Rt. femur, ilium. Possible Sacrum & liver? Now stage IV.
9-28-09 Loading dose of Herceptin & started Zometa
9-29-09 Power Port Placement
10-24-09 Mass 6.4 x 4.7 cm on Rt. femur head.
11-19-09 RT. Femur surgery - Rod placed
12-7-09 Navelbine added to Herceptin/Zometa.
3-23-10 Ten days of rads to RT femur. Completed.
4-05-10 Quit Navelbine--Herceptin/Zometa alone.
5-4-10 Appt. with Dr. Slamon to see what is next? Waiting on FISH results from femur biopsy.
Results to FISH was unsuccessful--this happens less then 2% of the time.
7-7-10 Recurrence to RT axilla again. Back to UCLA for options.
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Hybrid Mode
