Re: Efficacy and Safety of Neratinib (HKI-272) in Combination with Paclitaxel
Discussion: High clinical responses were observed in patients with Her2+ breast cancer, including the first-line subset and patient subsets with prior Her2-directed, endocrine, and taxane therapies. The combination of neratinib 240 mg and paclitaxel 80 mg/m2 was tolerable, with a toxicity profile similar to each drug given as monotherapy. A phase 3 trial is ongoing to study this combination in the first-line setting compared with trastuzumab plus paclitaxel.
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