HER2 Support Group Forums - Efficacy and Safety of Neratinib (HKI-272) in Combination with Paclitaxel

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- - Efficacy and Safety of Neratinib (HKI-272) in Combination with Paclitaxel (https://her2support.org/vbulletin/showthread.php?t=48059)

Hopeful

12-14-2010 12:53 PM

Efficacy and Safety of Neratinib (HKI-272) in Combination with Paclitaxel

Abstract:

http://www.abstracts2view.com/sabcs1...u=SABCS10L_744

Poster:

http://www.abstracts2view.com/sabcs1...hp?nu=P3-14-04

Hopeful

Rich66

04-17-2011 01:48 PM

Re: Efficacy and Safety of Neratinib (HKI-272) in Combination with Paclitaxel

Discussion: High clinical responses were observed in patients with Her2+ breast cancer, including the first-line subset and patient subsets with prior Her2-directed, endocrine, and taxane therapies. The combination of neratinib 240 mg and paclitaxel 80 mg/m<sup>2 </sup>was tolerable, with a toxicity profile similar to each drug given as monotherapy. A phase 3 trial is ongoing to study this combination in the first-line setting compared with trastuzumab plus paclitaxel.

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