HER2 Support Group Forums - View Single Post - way to make herceptin much more effective IDd

Mandamoo · 06-13-2013, 04:10 PM

Great reply thank you Lani!
My tries so far - I've done everolimus with herceptin and vinorelbine - best response - 7 months of stability
Tykerb and Xeloda - best response in reduction of disease but not maintained - progression after 5months (skin mets disappeared though - lung mets grew back)
TDM1 - no response really apart from slowing of progression
Herceptin, pertuzamab and carboplatin - significant progression (may have occurred awaiting pertuzamab as it was held up in customs - possible I was stable for a couple of months) currently changed carboplatin for Abraxane - have seem a small decline in tumor markers after first cycle - first decline in 12 months - scans next week.
My problem is I'm in Australia with limited access now to trials
I have spoken to one onc about afatinib - which I think is worth a go given my success with tykerb. Using everolimus again is an option too.
I've asked my onc to look into HSP90 options too.
I have a p53 mutation in the cancer also and I know I also highly express her3 but not EFGR or pi3k. But then not each tumor is the same.
I will look at the articles and info you suggest but I fear I will not be able to access anything here in Australia.
Thanks for taking the time to respond.

06-13-2013, 04:10 PM	#5
Mandamoo Senior Member Join Date: Jul 2011 Location: Melbourne, Australia Posts: 432	Re: way to make herceptin much more effective IDd Great reply thank you Lani! My tries so far - I've done everolimus with herceptin and vinorelbine - best response - 7 months of stability Tykerb and Xeloda - best response in reduction of disease but not maintained - progression after 5months (skin mets disappeared though - lung mets grew back) TDM1 - no response really apart from slowing of progression Herceptin, pertuzamab and carboplatin - significant progression (may have occurred awaiting pertuzamab as it was held up in customs - possible I was stable for a couple of months) currently changed carboplatin for Abraxane - have seem a small decline in tumor markers after first cycle - first decline in 12 months - scans next week. My problem is I'm in Australia with limited access now to trials I have spoken to one onc about afatinib - which I think is worth a go given my success with tykerb. Using everolimus again is an option too. I've asked my onc to look into HSP90 options too. I have a p53 mutation in the cancer also and I know I also highly express her3 but not EFGR or pi3k. But then not each tumor is the same. I will look at the articles and info you suggest but I fear I will not be able to access anything here in Australia. Thanks for taking the time to respond. __________________ Amanda xx 40 year old Mum to three gorgeous kids - son 5 and daughters 8 and 11 Wife to my wonderfully supportive husband of 17 years! 22 February 2011 - Diagnosed Early Breast Cancer IDBC Stage2b (ER/PR -ve, Her2+ve +++) - 38 years old (L) skin sparing mastectomy with tissue expander, axilla clearance (2/14 affected) clear margins. Fec3, Taxotere and herceptin2 - stopped due to secondary diagnosis June 24 2011 Stage IV - Skin met, axilla node, multiple lung lesions Bolero3 trial - Navelbine, Hereptin weekly, daily Everolimus/Placebo February 2012 - July 2012 Tykerb and Xeloda - skin mets resolved, Lungs initially dramatically reduced but growing again August 2012 (turn 40!) tykerb and herceptin (denied compassionate use of TDM1) while holidaying in Italy! September 2012 - January 2013 TDM1 as part of the Th3resa trial - lymph nodes resolved, lungs slowly progressing. January 2013 - herceptin, carboplatin and Perjeta (compassionate access) April 2013 - Some progression in lungs and lymph nodes - Abraxane, Herceptin and Perjeta July 2013 - mixed response - dramatic reduction of most lung disease, progression of smaller lung nodules and cervical and hilar nodes - ? Add avastin.