HER2 Support Group Forums - View Single Post

Becky · 01-29-2007, 04:05 PM

Dear Jean

I was always under the impression that there are no extra (or more) Her2 or other receptors, its just that they talk to each other since the hormone receptors are out of commission (that is what the "resistance" is but it is a misnomer. It is implying that the anti-hormonal isn't working when it probably is but other forces are causing the cancer to grow).

Theoretically, the Bayer Her2 serum test should work. If cancer is present, growing and reproducing, it would be shedding the extra cellular domain (I am just talking out loud here - maybe Lani or Heblaj01 can comment).

Real resistance might be if one knew that they were only hormone positive and the drug failed to work at all (estrogen was still high or one could later test to see if tamoxifen didn't cover the receptors).

I hope I helped you alittle bit.

01-29-2007, 04:05 PM	#6
Becky Senior Member Join Date: Sep 2005 Location: Stockton, NJ Posts: 4,179	Dear Jean I was always under the impression that there are no extra (or more) Her2 or other receptors, its just that they talk to each other since the hormone receptors are out of commission (that is what the "resistance" is but it is a misnomer. It is implying that the anti-hormonal isn't working when it probably is but other forces are causing the cancer to grow). Theoretically, the Bayer Her2 serum test should work. If cancer is present, growing and reproducing, it would be shedding the extra cellular domain (I am just talking out loud here - maybe Lani or Heblaj01 can comment). Real resistance might be if one knew that they were only hormone positive and the drug failed to work at all (estrogen was still high or one could later test to see if tamoxifen didn't cover the receptors). I hope I helped you alittle bit. __________________ Kind regards Becky Found lump via BSE Diagnosed 8/04 at age 45 1.9cm tumor, ER+PR-, Her2 3+(rt side) 2 micromets to sentinel node Stage 2A left 3mm DCIS - low grade ER+PR+Her2 neg lumpectomies 9/7/04 4DD AC followed by 4 DD taxol Used Leukine instead of Neulasta 35 rads on right side only 4/05 started Tamoxifen Started Herceptin 4 months after last Taxol due to trial results and 2005 ASCO meeting & recommendations Oophorectomy 8/05 Started Arimidex 9/05 Finished Herceptin (16 months) 9/06 Arimidex Only Prolia every 6 months for osteopenia NED 18 years! Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"