Which vaccine trial seems the most promising?

[waterdreamer]

I am interested to know of all the vaccine trials, which ladies are on what. If they have had a vaccine, how long have they remained NED? Or also please post if you had a vaccine and still progressed.

Thanks
Fern

['lizbeth]

Hello Fern,

I don't know about the stage IV trials, but I think there are other ladies that have enrolled.

The Walter Reed AE37/GP2 trial is for prevention with primary breast cancer. I've been enrolled in my GP2 arm for 2 1/2 years, am almost 5 years out from breast cancer and still NED. In this trial everyone is exposed to the vaccine twice - but is blindly randomized for the remaining injections and boosters.

[Sandra in GA]

HI Fern,
I am also in the Walter Reed Ae37/GP2 trial. I am a little behind 'lizbeth. I will have my last booster in September and am 4 years NED. Since I have a neg HLA-A2 factor, I am in the AS37 arm while 'lizabeth is in the GP2 arm. Of course, neither of us knows if we got the vaccine past the two mentioned above. In prior trials, folks like me who were neg to this blood factor were used as controls only because our bodies don't like to build antibodies and fight foreign invaders like people who have this factor. AE37 is supposed to "more vigoriously" stimulate our bodies to "stand up and fight." So far, positive results have been seen with this vaccine. It has also been used in a trial for prostate cancer.

[Sandra in GA]

http://us.lrd.yahoo.com/_ylt=Aqlfr3tp_wm8ifL4VoWOxVoIuodG;_ylu=X3oDMTFqaTN jbzlmBG1pdANBcnRpY2xlIEJvZHkEcG9zAzMEc2VjA01lZGlhQ XJ0aWNsZUJvZHlBc3NlbWJseQ--;_ylg=X3oDMTJubG1nOHR1BGludGwDdXMEbGFuZwNlbi11cwRw c3RhaWQDM2MzYWFiYTQtMjczNi0zNTVkLWE5NzktNGY5YjY4NG RmYzQ1BHBzdGNhdANuZXdzBHB0A3N0b3J5cGFnZQ--;_ylv=0/SIG=14h9pahm2/EXP=1347285293/**http%3A//www.oncuview.tv/Videos/TabId/79/VideoId/440/Breast-Cancer-Interview-With-Elizabeth-Ann-Mittendorf-MD-At-ASCO-2012.aspx

This is a very interesting interview with Dr. Mittendorf of MD Anderson. While it is specificially about AE37, there is also a lot in encouraging information about vaccines in general.