In Lab: Curcumin active against Her2 and may overcome Herceptin Resistance

[Hopeful]

Abstract:

http://www.abstracts2view.com/sabcs10/view.php?nu=SABCS10L_663

Poster:

http://www.abstracts2view.com/sabcs10/viewp.php?nu=P2-21-01

Hopeful

[Rich66]

In this preliminary study, we showed curcumin decrease the viability of various breast cancer cell lines (MCF-7, MDAMB-231, MCF-10A, BT-474 and SKBr-3(herceptin resistant, hr)). The combination of curcumin did not interfere with the action of herceptin. The herceptin sensitive BT-474 and herceptin resistant SKBr-3(hr) were all sensitive to curcumin treatment. In western blot analysis, the phosphorylation of HER-2, Akt, MAPK were reduced in BT-474 cells when treated with herceptin. In SKBr-3(hr) cells, the addition of herceptin did not downregulate the phosphorylation of HER-2, Akt, and MAPK. When treated with curcumin, the phosphorylation of HER-2, Akt, and MAPK of SKBr-3(hr) were decreased combined with the downregulation of HER-2 oncoprotein in a dose and time dependent manner.
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