Hopeful
07-20-2010, 06:34 AM
Provocative results:
"Gene expression changes after 14 days’ treatment with letrozole revealed different patterns of change in oestrogen regulated and proliferation genes in individual resistant tumours. Tumours could be separated into 3 different subgroups as follows: i) 9 cases in which both proliferation and oestrogen signalling signatures were generally reduced on treatment (ii) 4 cases in which both signatures were generally unaffected or increased with treatment and (iii) 2 cases in which expression of the majority of oestrogen-regulated genes decreased whereas proliferation genes remained unchanged or increased."
http://breast-cancer-research.com/content/pdf/bcr2611.pdf
Hopeful
"Gene expression changes after 14 days’ treatment with letrozole revealed different patterns of change in oestrogen regulated and proliferation genes in individual resistant tumours. Tumours could be separated into 3 different subgroups as follows: i) 9 cases in which both proliferation and oestrogen signalling signatures were generally reduced on treatment (ii) 4 cases in which both signatures were generally unaffected or increased with treatment and (iii) 2 cases in which expression of the majority of oestrogen-regulated genes decreased whereas proliferation genes remained unchanged or increased."
http://breast-cancer-research.com/content/pdf/bcr2611.pdf
Hopeful