Hopeful
02-16-2010, 07:56 AM
http://breast-cancer-research.com/content/pdf/bcr2479.pdf
Of interest:
"Results: We demonstrated that irradiated CICs (cancer initiating cells) survived and retained their self- renewal capacity for at least 4 generations. We showed that fractionated radiation not only spared CICs but also mobilized CICs from a quiescent/GO phase of the cell cycle into actively cycling cells while the surviving non-tumorogenic cells were driven into senesence.
Conclusion: We conclude that increases in the number of cancer initiating cells after sublethal does of radiation are potentially of clinical importance because the CIC subpopulation retains increased self-renewal capacity over several generations. Prevention of this process may therefore lead to improved clinical outcome."
Hopeful
Of interest:
"Results: We demonstrated that irradiated CICs (cancer initiating cells) survived and retained their self- renewal capacity for at least 4 generations. We showed that fractionated radiation not only spared CICs but also mobilized CICs from a quiescent/GO phase of the cell cycle into actively cycling cells while the surviving non-tumorogenic cells were driven into senesence.
Conclusion: We conclude that increases in the number of cancer initiating cells after sublethal does of radiation are potentially of clinical importance because the CIC subpopulation retains increased self-renewal capacity over several generations. Prevention of this process may therefore lead to improved clinical outcome."
Hopeful