Debbie L.
03-08-2009, 07:39 AM
Basal-HER2 phenotype shows poorer survival than basal-like phenotype in hormone receptor-negative invasive breast cancers
Résumé / Abstract
Previous studies have shown conflicting results on prognostic significance of basal-like breast tumors, but hormone receptor is a confusing factor in most of the prognostic evaluations. We aimed to characterize the prognostic features ofbasal-like tumors without the influence of hormone receptor status in a series of hormone receptor-negative breast tumors.
Using tissue microarray and immunohistochemistry methods, according to the expression of HER2 and basal markers (CK5/6, CK14, EGFR), we categorized 713 consecutive hormone receptor-negative invasive breast cancers into 3 subtypes: HER2 (HER2+), basal-like (HER2-, any basal marker+), and null (HER2-, all basal markers-). The HER2 phenotype was subdivided into pure-HER2 (HER2+, all basal markers-) and basal-HER2 (HER2+, any basal marker+) subgroups. Expression of p53, p63, vimentin, and BRCA1 was assessed immunochemically.
Basal-like tumors showed significantly higher grade, more frequent recurrence, and higher expression of vimentin and p63 than HER2 and null phenotypes. Basal-HER2 phenotype had significantly younger mean age and expressed a higher level of p53 and vimentin like basal-like and/or HER2 phenotypes. However, unlike all the other hormone receptor-negative phenotypes, they highly expressed BRCA1. No significant difference was found in 5-year survival among basal-like and the other hormone receptor-negative phenotypes, except for basal-HER2, which showed poorer 5-year overall survival than basal-like tumors.
In conclusion, although basal-like breast tumors have distinct clinicopathologic and immunohistochemical features, they have similar 5-year survival compared with the other hormone receptor-negative tumors including HER2 and null phenotypes. However, there exists a small group of hormone receptor-negative tumors expressing HER2 and basal markers simultaneously. This small group of tumors showed significantly poorer 5-year overall survival than basal-like breast tumors and might require different treatment strategy.
Auteur(s) / Author(s)
HUI LIU<sup> (1)</sup> ; QINHE FAN<sup> (2)</sup> ; ZHIHONG ZHANG<sup> (2)</sup> ; XIAO LI<sup> (2)</sup> ; HUIPING YU<sup> (3)</sup> ; FANQING MENG<sup> (4)</sup> ; Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
<sup>(1) </sup>Department of Pathology, Nanjing Medical University, Nanjing 210029, CHINE
<sup>(2) </sup>Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, CHINE
<sup>(3) </sup>School of Basic Medical Science, Southeast University, Nanjin 210009, CHINE
<sup>(4) </sup>Department of Pathology, The Affiliated Nanjing Drum Tower Hospital of Nanjing University, Nanjing 210008, CHINE
Revue / Journal Title
Human pathology ISSN 0046-8177 CODEN HPCQA4 Source / Source
2008, vol. 39, n<sup>o</sup>2, pp. 167-174 [8 page(s) (article)] (22 ref.)Langue / Language
Anglais
Editeur / Publisher
Elsevier, New York, NY, ETATS-UNIS (1970) (Revue)
Résumé / Abstract
Previous studies have shown conflicting results on prognostic significance of basal-like breast tumors, but hormone receptor is a confusing factor in most of the prognostic evaluations. We aimed to characterize the prognostic features ofbasal-like tumors without the influence of hormone receptor status in a series of hormone receptor-negative breast tumors.
Using tissue microarray and immunohistochemistry methods, according to the expression of HER2 and basal markers (CK5/6, CK14, EGFR), we categorized 713 consecutive hormone receptor-negative invasive breast cancers into 3 subtypes: HER2 (HER2+), basal-like (HER2-, any basal marker+), and null (HER2-, all basal markers-). The HER2 phenotype was subdivided into pure-HER2 (HER2+, all basal markers-) and basal-HER2 (HER2+, any basal marker+) subgroups. Expression of p53, p63, vimentin, and BRCA1 was assessed immunochemically.
Basal-like tumors showed significantly higher grade, more frequent recurrence, and higher expression of vimentin and p63 than HER2 and null phenotypes. Basal-HER2 phenotype had significantly younger mean age and expressed a higher level of p53 and vimentin like basal-like and/or HER2 phenotypes. However, unlike all the other hormone receptor-negative phenotypes, they highly expressed BRCA1. No significant difference was found in 5-year survival among basal-like and the other hormone receptor-negative phenotypes, except for basal-HER2, which showed poorer 5-year overall survival than basal-like tumors.
In conclusion, although basal-like breast tumors have distinct clinicopathologic and immunohistochemical features, they have similar 5-year survival compared with the other hormone receptor-negative tumors including HER2 and null phenotypes. However, there exists a small group of hormone receptor-negative tumors expressing HER2 and basal markers simultaneously. This small group of tumors showed significantly poorer 5-year overall survival than basal-like breast tumors and might require different treatment strategy.
Auteur(s) / Author(s)
HUI LIU<sup> (1)</sup> ; QINHE FAN<sup> (2)</sup> ; ZHIHONG ZHANG<sup> (2)</sup> ; XIAO LI<sup> (2)</sup> ; HUIPING YU<sup> (3)</sup> ; FANQING MENG<sup> (4)</sup> ; Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
<sup>(1) </sup>Department of Pathology, Nanjing Medical University, Nanjing 210029, CHINE
<sup>(2) </sup>Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, CHINE
<sup>(3) </sup>School of Basic Medical Science, Southeast University, Nanjin 210009, CHINE
<sup>(4) </sup>Department of Pathology, The Affiliated Nanjing Drum Tower Hospital of Nanjing University, Nanjing 210008, CHINE
Revue / Journal Title
Human pathology ISSN 0046-8177 CODEN HPCQA4 Source / Source
2008, vol. 39, n<sup>o</sup>2, pp. 167-174 [8 page(s) (article)] (22 ref.)Langue / Language
Anglais
Editeur / Publisher
Elsevier, New York, NY, ETATS-UNIS (1970) (Revue)