ovarian abalatioin upregulates her2

[RobinP]

http://www.ncbi.nlm.nih.gov/pubmed/14503797

Older article, but interesting that estrogen/progesterone down regulates her2.

[dilly]

Is upregulation good or bad?

[Janelle]

Can you dumb this down for me? Does this study suggest we should consider NOT taking drugs that remove estrogen from our bodies (tamox) if we are triple positives???

Thanks!
Janelle

[Nguyen]

Upregulation: increasing - downregulation: decreasing.
In this case, increasing the level of her2/neu.

Usually Increasing Her2/neu level indicates recurring disease or resisting disease. HOWEVER, the abstract specifically said that since the CA27.29 was "unchanged", this increasing in Her2/neu can not be used as a disease status indicator.

I don't think just this one study can be used to "...NOT taking drugs...estrogen..." as per Janelle question. Tripple postive (ER+, PR+, Her2+) tumor will "increase" the remaining receptors to compensate when the other is blocked. I think there are data that indicate Her2+ tumor become resistance to tamoxifen faster than Her2 negative.

Nguyen

[Janelle]

Thanks for your input, Nguyen!