Lani
07-11-2007, 07:05 AM
not very informative article--but "friends,neighbors, family" might want to let you know it is out there.
No need to read. Just says herceptin does not work for everyone and some people it only works for a certain length of time, ..nothing any of you do not know
ARTI CLES
Mediators of vascular remodelling co-opted
for sequential steps in lung metastasis
Gaorav P. Gupta1*, Don X. Nguyen1*, Anne C. Chiang1,2, Paula D. Bos1, Juliet Y. Kim1, Cristina Nadal1{,
Roger R. Gomis1{, Katia Manova-Todorova3 & Joan Massague?1,4
Metastasis entails numerous biological functions that collectively enable cancerous cells from a primary site to disseminate
and overtake distant organs. Using genetic and pharmacological approaches, we show that the epidermal growth factor
receptor ligand epiregulin, the cyclooxygenase COX2, and the matrix metalloproteinases 1 and 2, when expressed in human
breast cancer cells, collectively facilitate the assembly of new tumour blood vessels, the release of tumour cells into the
circulation, and the breaching of lung capillaries by circulating tumour cells to seed pulmonary metastasis. These findings
reveal how aggressive primary tumorigenic functions can be mechanistically coupled to greater lung metastatic potential,
and how such biological activities may be therapeutically targeted with specific drug combinatiVol 446 | 12 April 2007 | doi:10.1038/nature05760
No need to read. Just says herceptin does not work for everyone and some people it only works for a certain length of time, ..nothing any of you do not know
ARTI CLES
Mediators of vascular remodelling co-opted
for sequential steps in lung metastasis
Gaorav P. Gupta1*, Don X. Nguyen1*, Anne C. Chiang1,2, Paula D. Bos1, Juliet Y. Kim1, Cristina Nadal1{,
Roger R. Gomis1{, Katia Manova-Todorova3 & Joan Massague?1,4
Metastasis entails numerous biological functions that collectively enable cancerous cells from a primary site to disseminate
and overtake distant organs. Using genetic and pharmacological approaches, we show that the epidermal growth factor
receptor ligand epiregulin, the cyclooxygenase COX2, and the matrix metalloproteinases 1 and 2, when expressed in human
breast cancer cells, collectively facilitate the assembly of new tumour blood vessels, the release of tumour cells into the
circulation, and the breaching of lung capillaries by circulating tumour cells to seed pulmonary metastasis. These findings
reveal how aggressive primary tumorigenic functions can be mechanistically coupled to greater lung metastatic potential,
and how such biological activities may be therapeutically targeted with specific drug combinatiVol 446 | 12 April 2007 | doi:10.1038/nature05760