RobinP
06-18-2007, 02:51 PM
PS. I don't advocate soy for hormonal positives, but I think its okay in moderate amounts for hormonal negatives and perhaps even beneficial in inhibiting the her2 pathway as described in this article:http://breast-cancer-research.com/content/6/3/119
"Dietary phyto-oestrogens are capable of inhibiting the proliferation of hormone-independent breast cell lines [43 (http://breast-cancer-research.com/content/6/3/119#B43),54 (http://breast-cancer-research.com/content/6/3/119#B54),58 (http://breast-cancer-research.com/content/6/3/119#B58),69 (http://breast-cancer-research.com/content/6/3/119#B69)]. It has been proposed that growth inhibition in the absence of functional ER occurs via the inhibition of tyrosine kinase activity. The protein tyrosine kinases are involved in a number of growth factor signalling pathways, including transforming growth factor (TGF)-α, insulin-like growth factor (IGF)-I, IGF-II and epidermal growth factor (EGF or HER2). In ER-negative breast cancer cultures 5 μmol/l genistein negated the stimulatory effects of TGF-α, IGF-I and IGF-II, implying the inhibition of tyrosine kinase activity [23 (http://breast-cancer-research.com/content/6/3/119#B23)]. The human EGF receptor-2 oncogene (Her-2) is constitutively overexpressed in approximately 30% of breast cancers and is associated with a poor patient prognosis [71 (http://breast-cancer-research.com/content/6/3/119#B71)]. Research using breast cancer cell lines suggests that dietary phyto-oestrogens are capable of repressing EGF receptor activity. The inhibition of tyrosine kinase activity by 5 μmol/l genistein in MCF-7 cells correlated with the repression of EGF receptor tyrosine phosphorylation in response to EGF stimulation [23 (http://breast-cancer-research.com/content/6/3/119#B23)]. Similar findings were reported in a recent study investigating the chemoprotective effects of the green tea polyphenol epigallocatechin-3 gallate (EGCG). The treatment of Her-2/neu over-expressing mouse mammary cells with 20–80 μg/ml EGCG inhibited proliferation in a dose-dependent manner, correlating with a reduction in Her-2/neu signalling activity [72 (http://breast-cancer-research.com/content/6/3/119#B72)]. The basal tyrosine phosphorylation of Her-2/neu was decreased by approximately 96% following treatment with 80 μg/ml EGCG. Downstream activities of the signalling proteins phosphoinositide 3-kinase, Akt and nuclear factor-κB were similarly repressed, suggesting a potential clinical application of EGCG in breast cancer therapy."
SOY SUMMARIES:
http://www.mskcc.org/mskcc/html/69383.cfm#References
http://www.mdanderson.org/departments/cimer/display.cfm?id=4B0FB06E-7655-4487-9146CCE58AA7D403&method=displayFull&pn=6EB86A59-EBD9-11D4-810100508B603A14
http://www.ahrq.gov/clinic/epcsums/soysum.htm
best type of soy is fermented:
http://www.mercola.com/2004/aug/4/fermented_soy.htm
"Dietary phyto-oestrogens are capable of inhibiting the proliferation of hormone-independent breast cell lines [43 (http://breast-cancer-research.com/content/6/3/119#B43),54 (http://breast-cancer-research.com/content/6/3/119#B54),58 (http://breast-cancer-research.com/content/6/3/119#B58),69 (http://breast-cancer-research.com/content/6/3/119#B69)]. It has been proposed that growth inhibition in the absence of functional ER occurs via the inhibition of tyrosine kinase activity. The protein tyrosine kinases are involved in a number of growth factor signalling pathways, including transforming growth factor (TGF)-α, insulin-like growth factor (IGF)-I, IGF-II and epidermal growth factor (EGF or HER2). In ER-negative breast cancer cultures 5 μmol/l genistein negated the stimulatory effects of TGF-α, IGF-I and IGF-II, implying the inhibition of tyrosine kinase activity [23 (http://breast-cancer-research.com/content/6/3/119#B23)]. The human EGF receptor-2 oncogene (Her-2) is constitutively overexpressed in approximately 30% of breast cancers and is associated with a poor patient prognosis [71 (http://breast-cancer-research.com/content/6/3/119#B71)]. Research using breast cancer cell lines suggests that dietary phyto-oestrogens are capable of repressing EGF receptor activity. The inhibition of tyrosine kinase activity by 5 μmol/l genistein in MCF-7 cells correlated with the repression of EGF receptor tyrosine phosphorylation in response to EGF stimulation [23 (http://breast-cancer-research.com/content/6/3/119#B23)]. Similar findings were reported in a recent study investigating the chemoprotective effects of the green tea polyphenol epigallocatechin-3 gallate (EGCG). The treatment of Her-2/neu over-expressing mouse mammary cells with 20–80 μg/ml EGCG inhibited proliferation in a dose-dependent manner, correlating with a reduction in Her-2/neu signalling activity [72 (http://breast-cancer-research.com/content/6/3/119#B72)]. The basal tyrosine phosphorylation of Her-2/neu was decreased by approximately 96% following treatment with 80 μg/ml EGCG. Downstream activities of the signalling proteins phosphoinositide 3-kinase, Akt and nuclear factor-κB were similarly repressed, suggesting a potential clinical application of EGCG in breast cancer therapy."
SOY SUMMARIES:
http://www.mskcc.org/mskcc/html/69383.cfm#References
http://www.mdanderson.org/departments/cimer/display.cfm?id=4B0FB06E-7655-4487-9146CCE58AA7D403&method=displayFull&pn=6EB86A59-EBD9-11D4-810100508B603A14
http://www.ahrq.gov/clinic/epcsums/soysum.htm
best type of soy is fermented:
http://www.mercola.com/2004/aug/4/fermented_soy.htm