heblaj01
05-24-2006, 11:37 AM
Previous posts have described experimental studies (mostly in-vitro) involving the combination of one of the statin drugs (normally used to control cholesterol) & one of the insulin sensitizers (used by diabetics).
Here is an other one combining lovastatin and troglitazone:
Dramatic synergistic anticancer effect of clinically achievable doses of lovastatin and troglitazone.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16094629&query_hl=5&itool=pubmed_DocSum
The drug troglitazone has long been volontarily withdrawn from market by the supplier due to a small number of liver failures in diabetics & also because other drugs in the same class (devoid of this side effect) available which dried up the demand for it.
This side effect is not necessarily an obstacle for using it in cancer treatment as can be seen in the case of thalidomide which was forbidden for a long time until it found an application in cancer.
I noticed at least one poster (Kay) who has at one time been on Lovastatin.
Since statin & insulin sensitizer drugs are approved medications I wonder if any one else has been treated off label with a statin drug in combination with an insulin sensitizer such as pioglitazone or rosiglitazone (if not troglitazone)?
(http://www.diabetesmonitor.com/actos.htm)
Here is an other one combining lovastatin and troglitazone:
Dramatic synergistic anticancer effect of clinically achievable doses of lovastatin and troglitazone.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16094629&query_hl=5&itool=pubmed_DocSum
The drug troglitazone has long been volontarily withdrawn from market by the supplier due to a small number of liver failures in diabetics & also because other drugs in the same class (devoid of this side effect) available which dried up the demand for it.
This side effect is not necessarily an obstacle for using it in cancer treatment as can be seen in the case of thalidomide which was forbidden for a long time until it found an application in cancer.
I noticed at least one poster (Kay) who has at one time been on Lovastatin.
Since statin & insulin sensitizer drugs are approved medications I wonder if any one else has been treated off label with a statin drug in combination with an insulin sensitizer such as pioglitazone or rosiglitazone (if not troglitazone)?
(http://www.diabetesmonitor.com/actos.htm)