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02-28-2015, 11:05 AM
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#1
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Senior Member
Join Date: Aug 2010
Location: New York, New York
Posts: 1,580
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Is This The End Of Cancer?
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03-01-2015, 12:41 AM
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#2
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Senior Member
Join Date: Oct 2005
Location: New Jersey
Posts: 3,154
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Re: Is This The End Of Cancer?
I watched the exciting Vice program on HBO. Shane Smith is the founder of the program. His mother was dx. with breast cancer. His step mother also was dx with breast cancer. This report was personal for him.
Vice is a program that does documentaries and special reports. Each week there is a different report. This week was cancer.
The show opened filming at MD Anderson, with an experiential procedure. Injecting a virus into the brain tumor. The viruses / diseases that once killed us, like small pox, measles now may hold the key to a cure.
Dr. John Bell, at the Ottawa hospital for innovative cancer research is credited as the first to figure out the virus without harming the healthy cells. It had been suspected since the early 1900's that viruses attacked cancer cells.
Dr. Bell research took a leap 5 yrs. ago. The virus attacks the cancer, enters the cell and the cancer cell explodes.
Heathly cells are not harmed. This is a revolutionary treatment. It is a rapidly developing field.
Dr. Steven Russell at the Mayo Clinic, engineered a measles virus. The virus that Dr. Russell used was original from the throat of a boy who had the measles in 1954.
Dr. Russell added a new gene into the virus in order to make it better for treating cancer.
Two patients with Multiple myeloma (which is a cancer that accumulates in the bone marrow) and the virus treatment is their last hope, as both men exhausted all treatments. Both patients were injected with the measles virus. This is a phase 11 trial.
A week after treatment both patients go back to the hospital (8 days) both patients had a hard reaction,
severe bone pain, nausea and fatigue. Both were better a week later.
In the phase 1 trail a women was treated (she also had exhausted all known treatments) she had a huge tumor presenting on her head. The size of a golf ball. She had an amazing reaction. Her recovery is a miraculous.
After a single injection, she had a severe headache, high fever. 36 hrs. after the treatment the huge golf ball tumor on her forehead was gone. This is the first time in history that a virus is documented that has eradicated cancer.
She has energy and is feeling strong. The cancer is gone from her body. As they said in the report, the virus loves to beat up on the cancer. This patient is 18 months out from the treatment and she NED. This virus treatment destroyed all her tumors. Again, healthy tissue is not harmed. The virus goes throughout the body and attacks all the tumors. She had a single injection/treatment.
The virus also deactivates the cancers ability to suppress our immune system. Very ground breaking indeed.
Dr. Juan Fueyo is the director of the brain tumor research program at MD Anderson. He is working with the common cold virus. The researchers genetically modified the adenovirus to attack brain tumors. Dr. Fredrick Lang a neuro surgeon who works with Dr. Fueyo on this phase 1 trial. They took brain tumors from humans and placed them in mice. Then treated them with the virus and the tumors were attacked and destroyed. The report shows a patient being treated with the cold virus directly into his brain tumor. 25 people were treated and 3 had NED. Again, this is a phase 1 trial. The treatment and surgery takes 5 hrs. 6 weeks after the patients surgery the tumor has stopped growing.
We already use live virus for vaccines. The report states that the next five years using viruses will be a main driver to treat cancer. Both of these treatments are in the early stages. They are trying to fast track the treatment.
There is a radical new therapy virus treatment using the HIV virus. At the children's hospital of Pennsylvania. Since this virus is one of the dreaded viruses that causes aids, you could imagine that the news of this deadly virus was offering the best chance of all was so surprising.
The Children's Hospital is using the HIV virus to treat leukemia. A little girl who had reached the end of known treatments went to the hospital as a last hope for treatment.
Dr. Carl June who studied HIV and cancer for the Tcell treatment. Dr. June learned how to use HIV to reprogram the virus. The patient cannot get HIV from the treatment. This treatment is a T cell killing treatment.
Three adults were treated. 21 days after treatment all had no leukemia.
4 weeks after the little girl was treated (she was the 4th and 1st child) she is in total remission NED and the three adults are also in full remission. NED
These are ground breaking results. 39 children have now been treated and 90% of them have experienced complete remission, for 2 plus years. There has never been a treatment that has done this.
There are 300 kinds of cancer. Dr. June is taking about a cure. This virus should be approved by FDA by 2016. Dr.June believes many of those 300 cancers will be cured. The dr's know they are on the right path. This is the biggest news in cancer since chemo/and/radiation.
Taking viruses that used to kill us are now saving lives.
This is a paradigm shift in treating cancer.
So, YES dear sisters, the end is near.
I hope that all can view this documentary.
Jean
__________________
Stage 1, Grade 1, 3/30/05
Lumpectomy 4/15/05 - 6MM IDC
Node Neg. (Sentinel node)
ER+ 90% / PR-, Her2+++ by FISH
Ki-67 40%
Arimidex 5/05
Radiation 32 trt, 5/30/05
Oncotype DX test 4/17/06, 31% high risk
TOPO 11 neg. 4/06
Stopped Arimidex 5/06
TCH 5/06, 6 treatments
Herceptin 5/06 - for 1 yr.
9/06 Completed chemo
Started Femara Sept. 2006
Last edited by Jean; 03-01-2015 at 12:50 AM..
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03-01-2015, 05:16 AM
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#3
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Senior Member
Join Date: Sep 2005
Location: france
Posts: 1,648
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Re: Is This The End Of Cancer?
couldn't see the doc but this method does seem useful for overcoming the blood/brain barrier. I think malaria was another one tried for this reason.
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03-01-2015, 08:29 AM
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#4
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Senior Member
Join Date: Jun 2011
Location: Somerset, NJ
Posts: 487
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Re: Is This The End Of Cancer?
Here's a direct link to the video, sarah. Maybe you can see that.
https://www.youtube.com/watch?v=e8SvBAjXGyQ#t=416
__________________
2/6/09 Core needle biopsy: negative; Mammos through 2010: no change
3/30/11 Pea-sized lump in left breast at site of prior biopsy; mammo negative, sonogram not so much
4/14/11 Core needle biopsy: negative for cancer
5/18/11 Excisional biopsy 1.2 cm tumor, LVI, positive margin; ER+60%,PR+20%,HER2/CEP17 5
6/15/11 BMX: Left DCIS & LH; Right ADH; SNB: 2/3 nodes: 1.4 cm and 1 mm; ALND L1&2: 0/10; Stage IIa, Grade 3
7/14/11 CT/Bone scans NED; MUGA 66%
7/19/11 Biweekly dd AC w/Neulasta; done 8/30/11
9/13/11 Transfusion (Hemoglobin 8.6); MUGA 64%
9/20/11 Start Taxol + Herceptin; Taxol done 12/6/2011; continue Herceptin until 9/4/2012
12/27/11 Radiation - 6 weeks; 2/27/2012 - DONE! Yayyyy!
2/29/12 Start Tamoxifen 20 mg/day; continue until 2/28/17
5/16/12 Start five-years Metformin trial
6/19/12 MUGA 61%
8/21/12 Brain MRI NED (head still hurts, brain still fogged)
9/4/12 Herceptin done!
9/6/12 Port out!
7/11/13 Aricept 5mg for cognitive impairment; increased to 10mg as of 8/23/13; back to 5mg 12/2013
5/2014 Add Namenda 7mg
9/2014 Stop Aricept and Namenda; Neuropsychological evaluation
10/24/14 Start cognitive rehabilitation therapy
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03-01-2015, 11:16 AM
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#5
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Senior Member
Join Date: Aug 2010
Location: New York, New York
Posts: 1,580
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Re: Is This The End Of Cancer?
Sorry about the link not working and thank you, Rhondalea for posting a direct link.
Karen
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03-01-2015, 01:46 PM
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#6
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Senior Member
Join Date: Nov 2004
Location: Misty woods of WA State
Posts: 4,128
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Re: Is This The End Of Cancer?
This is very exciting.
My hubby just commented, "If they can cure Ebola, they should be able to find something easier for cancer!" There have been some more breakthroughs against Ebola in Europe recently.
Thanks for the link.
__________________
"When I hear music, I fear no danger. I am invulnerable. I see no foe. I am related to the earliest times, and to the latest." H.D. Thoreau
Live in the moment.
MY STORY SO FAR ~~~~
Found suspicious lump 9/2000
Lumpectomy, then node dissection and port placement
Stage IIB, 8 pos nodes of 18, Grade 3, ER & PR -
Adriamycin 12 weekly, taxotere 4 rounds
36 rads - very little burning
3 mos after rads liver full of tumors, Stage IV Jan 2002, one spot on sternum
Weekly Taxol, Navelbine, Herceptin for 27 rounds to NED!
2003 & 2004 no active disease - 3 weekly Herceptin + Zometa
Jan 2005 two mets to brain - Gamma Knife on Jan 18
All clear until treated cerebellum spot showing activity on Jan 2006 brain MRI & brain PET
Brain surgery on Feb 9, 2006 - no cancer, 100% radiation necrosis - tumor was still dying
Continue as NED while on Herceptin & quarterly Zometa
Fall-2006 - off Zometa - watching one small brain spot (scar?)
2007 - spot/scar in brain stable - finished anticoagulation therapy for clot along my port-a-catheter - 3 angioplasties to unblock vena cava
2008 - Brain and body still NED! Port removed and scans in Dec.
Dec 2008 - stop Herceptin - Vaccine Trial at U of W begun in Oct. of 2011
STILL NED everywhere in Feb 2014 - on wing & prayer
7/14 - Started twice yearly Zometa for my bones
Jan. 2015 checkup still shows NED
2015 Neuropathy in feet - otherwise all OK - still NED.
Same news for 2016 and all of 2017.
Nov of 2017 - had small skin cancer removed from my face. Will have Zometa end of Jan. 2018.
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03-01-2015, 04:27 PM
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#7
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Senior Member
Join Date: Jun 2011
Location: Somerset, NJ
Posts: 487
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Re: Is This The End Of Cancer?
Watching that video was a privilege, Karen. I posted it to my FB page, and I'll probably post it to other sites as time goes on. Thank you for finding and sharing it. I am so very hopeful that these treatments are the miracle we've all been waiting for.
__________________
2/6/09 Core needle biopsy: negative; Mammos through 2010: no change
3/30/11 Pea-sized lump in left breast at site of prior biopsy; mammo negative, sonogram not so much
4/14/11 Core needle biopsy: negative for cancer
5/18/11 Excisional biopsy 1.2 cm tumor, LVI, positive margin; ER+60%,PR+20%,HER2/CEP17 5
6/15/11 BMX: Left DCIS & LH; Right ADH; SNB: 2/3 nodes: 1.4 cm and 1 mm; ALND L1&2: 0/10; Stage IIa, Grade 3
7/14/11 CT/Bone scans NED; MUGA 66%
7/19/11 Biweekly dd AC w/Neulasta; done 8/30/11
9/13/11 Transfusion (Hemoglobin 8.6); MUGA 64%
9/20/11 Start Taxol + Herceptin; Taxol done 12/6/2011; continue Herceptin until 9/4/2012
12/27/11 Radiation - 6 weeks; 2/27/2012 - DONE! Yayyyy!
2/29/12 Start Tamoxifen 20 mg/day; continue until 2/28/17
5/16/12 Start five-years Metformin trial
6/19/12 MUGA 61%
8/21/12 Brain MRI NED (head still hurts, brain still fogged)
9/4/12 Herceptin done!
9/6/12 Port out!
7/11/13 Aricept 5mg for cognitive impairment; increased to 10mg as of 8/23/13; back to 5mg 12/2013
5/2014 Add Namenda 7mg
9/2014 Stop Aricept and Namenda; Neuropsychological evaluation
10/24/14 Start cognitive rehabilitation therapy
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03-01-2015, 05:44 PM
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#8
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Senior Member
Join Date: Jan 2010
Location: Thousand Oaks, California.
Posts: 199
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Re: Is This The End Of Cancer?
Thanks so much for posting this. Fever is a big factor in many remissions, as the cancer cannot survive the heat produced by the body. Hyperthermia makes many treatments that much more successful.
__________________
Breastfeeding when diagnosed with Her2+ May 2008
Oct 2008 Double mastectomy 22/28 lymph nodes positive
Decline chemotherapy (decision I regret)
Nov 2009 Mets to lungs and bones.
Dec 2009 Start Taxotere and Herceptin, T1, T3 heal completely and lungs are clear, T2 and first rib have lytic lesions. First rib becomes sclerotic. Considered stable.
May 2011, Onc calls progression and I cross over from comparison arm of clinical trial to TDM-1
Brain scan in Sept 2011 showed small tumor in right cerebellum, did Novalis radiation.
Feb 2013 < 1cm tumor in left frontal lobe. Did Novalis in March and latest scan shows no sign of brain metastasis.
Aug 2013 did 36th round of TDM-1 Due to TDM-1 side effects, shortness of breath, and difficulty getting my balance when getting out of bed, agreed with my oncologist to stop TDM-1.
Took a six week break, bone scan showed small uptake on left first rib. CT showed hypodensities in liver (too small to biopsy) and small nodule in lungs (mediastinal).
Started Navelbine weekly. Did one round with Herceptin.
Skipped next 2 rounds, due to neutropenia. Next chemo 7th Nov - have had 3 Neupogen shots, so WBC should look better... Did not tolerate Navelbine well.
December 2013 scans show no sign of active cancer.
March 2014 - currently only on Herceptin - brain MRI clear, PET/CT two nodules in right lung show uptake
May 2014 - stop Herceptin.
Sept 22, 2014 Brain MRI clear :) PET/CT Progression in lungs.
Sept 2014, Xeloda, Tykerb and Herceptin.
Nov 2014 - Decide to take a break from all treatment.
May 2015 - Brain met radiated with Novalis
July 2015 - Have progression in right lung.
Sept 2015 - Perjeta and Herceptin alone after a 9 month break from all treatment.
Nov 2015 - Thoracentesis 1500ml removed from right lung.
Dec 2015 - Two tiny 1mm brain mets radiated in right cerebellum.
Feb 2016 - Thoracentesis 2200ml drained from right lung
Feb 2016 - Stopped Perjeta and Herceptin and started back on Kadcyla as I had no previous progression on it. After 1 cycle of Kadcyla markers begin to drop. On second cycle add Keytruda.
March 2016 - Thoracentesis 1650ml drained from right lung.
April 2016 – Thoracentesis 1500 ml drained from right lung.
June 2016 – CT scan shows progression in right lung, as well as moderate pleural effusion requiring Thoracentesis.
June 2016 – Decide to stop Keytruda, and will do chemosensitivity test through Rational Therapeutics. Plan to continue on Kadcyla for next two cycles.
July 2016 - Start weekly Abraxane with Herceptin. WBRT with hippocampal sparing, Taking Namenda. 15 sessions over 3 weeks.
Aug - Dec 2016 - 2 infusions of Navelbine, very hard on my body and still dealing with anasarca (generalized edema) 1 infusion of Havalen
My doctor wants to put me on hospice.
Dec 23rd 2016 - I am granted compassionate use of Neratanib.
May 31st 2017 - still on Neratinib, feeling good.
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03-02-2015, 02:27 PM
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#9
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Senior Member
Join Date: Feb 2014
Location: California
Posts: 439
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Re: Is This The End Of Cancer?
Normally I don't get into reading all the possible miracle drugs that might cure cancer probably because I feel they are so far from curing cancer I just don't go there. But to read this just brought me such great hope for not just myself but for so many others and other cancers. I guess I have always believed how can they find a cure for Cancer when there are so many different types of cancers. It just seems like an impossible task. Unlike other diaseses Cancer has so so many types. But this ladies has put a smile on my face. And Ummm 2016 is just right around the corner.
__________________
]11/13 Dx IDC left breast
11/19/2013 Inflammatory Breast Cancer stage 3c grade 2 Er- Pr- her2+++
Node involvement suspected based on CT
12/13 port placed
12/13 neoadjuvant DD AC xs 4 rounds started
02/14 taxol/herceptin started every week xs 12 rounds
Herceptin for 1 year
Ki67=23%
BRCA1&2 negative
5/06/14 last round taxol/herceptin. Chemo done!!!
5/07/14 clear CT scan
6/11/14 Bilateral Mastectomy Done
6/15/14 8mm tumor post chemo. Removed by bmx
6/15/14 lymph nodes 0/9
6/15/14 officially Cancer Free
7/11/14 emergency surgery to left breast . Wound refused to heal and broke open. New TE placed
7/28/14 emergency medical procedure now to right breast( post op 6 weeks mastectomy ) wound opens.
8/25/14 - 10/07/14 Radiation
11/24/14 CT of Brain clear
01/23/15 One year Herceptin Complete
02/04/15 Diep done
5/01/15 1 year Ct scan- mass in thymus
6/23/15 repeat CT mass in thymus still present
6/30/15 biopsy thymus 7/03/15 mass Benign! Diagnoses Thymic hyperplasia rebound ( chemo at fault, no long term health effects)
7/08/15 phase 2 diep
11/23/15 phase 2b ( reconstructive surgery with lipo)
03/05/18 Vinnie Myer 3 D nipple tattoos complete.
11/19/2018 5 years since Dx of IBC stage 3c remain NED.
11/19/21- 8 years today I officially remain NED and in 12 days I will be having a lymphnode transfer to help decrease some mild lymphedema! Still working, living life and soon to see a day I thought never would happen and that’s becoming a grandparent June 22nd.
11/19/2023 - 10 years since diagnosis and I remain NED
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03-02-2015, 03:30 PM
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#10
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Senior Member
Join Date: Feb 2014
Location: California
Posts: 439
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Re: Is This The End Of Cancer?
I just watched the video and it looks promising. Talk about giving hope to so many and truly possibly in 2016. It is exciting
__________________
]11/13 Dx IDC left breast
11/19/2013 Inflammatory Breast Cancer stage 3c grade 2 Er- Pr- her2+++
Node involvement suspected based on CT
12/13 port placed
12/13 neoadjuvant DD AC xs 4 rounds started
02/14 taxol/herceptin started every week xs 12 rounds
Herceptin for 1 year
Ki67=23%
BRCA1&2 negative
5/06/14 last round taxol/herceptin. Chemo done!!!
5/07/14 clear CT scan
6/11/14 Bilateral Mastectomy Done
6/15/14 8mm tumor post chemo. Removed by bmx
6/15/14 lymph nodes 0/9
6/15/14 officially Cancer Free
7/11/14 emergency surgery to left breast . Wound refused to heal and broke open. New TE placed
7/28/14 emergency medical procedure now to right breast( post op 6 weeks mastectomy ) wound opens.
8/25/14 - 10/07/14 Radiation
11/24/14 CT of Brain clear
01/23/15 One year Herceptin Complete
02/04/15 Diep done
5/01/15 1 year Ct scan- mass in thymus
6/23/15 repeat CT mass in thymus still present
6/30/15 biopsy thymus 7/03/15 mass Benign! Diagnoses Thymic hyperplasia rebound ( chemo at fault, no long term health effects)
7/08/15 phase 2 diep
11/23/15 phase 2b ( reconstructive surgery with lipo)
03/05/18 Vinnie Myer 3 D nipple tattoos complete.
11/19/2018 5 years since Dx of IBC stage 3c remain NED.
11/19/21- 8 years today I officially remain NED and in 12 days I will be having a lymphnode transfer to help decrease some mild lymphedema! Still working, living life and soon to see a day I thought never would happen and that’s becoming a grandparent June 22nd.
11/19/2023 - 10 years since diagnosis and I remain NED
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03-03-2015, 12:25 AM
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#11
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Senior Member
Join Date: Oct 2012
Posts: 29
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Re: Is This The End Of Cancer?
The best part about the report was that doctors sound excited about the treatment. That almost never happens.
__________________
April 2004 - DXd with DCIS in right breast
April 2004 - Bilateral Mastectomies
NED until
October 2012 - DXd with IDC near right,
reconstructed breast, 1.9cm, grade 1, no
LVI, ER+/PR-/HER2+
November 2012 - 2 lumpectomies, clear bone scan, clear CT scan
April 2013 - 6 rounds of TCH completed
30 rads completed in July 2013
Herceptin completed in November 2013
10 years of Tamoxifen to go
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03-04-2015, 02:17 PM
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#12
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Senior Member
Join Date: Oct 2005
Location: LAND OF YES!
w/home in Boca Raton, Florida
Orig from L.I., N.Y.
Ever hovering IN THE NOW...
Posts: 1,904
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Re: Is This The End Of Cancer?
Truly exciting news. Thanks Karen and Jean and Rhondalea for sharing.
Years ago a man we know had 4th stage melanoma. He was given Thalidomide (remember that horror of a drug erroneously given to pregnant women who then had horribly deformed babies??) -- well this man is doing well (maybe 10 yrs later). The idea captivated me that something that was so awful (utilized in one way) could miraculously send cancer packing!
Living in hope is no longer a frivolous activity, Ladies!
The FDA fast-tracked Herceptin in '98, which helped save my life for sure. It's time to get fast-tracking again, FDA. THIS IS HUGE!
__________________
Andi BB
'95 post-meno dx Invasive LOBULAR w/9cm tumor! YIKES + 2/21 nodes. Clear mammo 10 mnths earlier. Mastec/tram flap reconst/PORT/8 mnths chemo (4Adria/8CMF). Borderline ER/PR. Tamoxifen 2 yrs. Felt BLESSED. I could walk and talk, feed and bathe myself! I KNEW I would survive...
'98 -- multiple mets to liver. HER2+ 80%. ER/PR- Raging, highly aggressive tumors spreading fast. New PORT. 9 mnths Taxotere Fought fire w/fire! Pronounced in cautious remission 5/99. Taxotere weekly for 6 wks, 2 wks off -- for 9 mnths. TALK ABOUT GRUELING! (I believe they've altered that protocol since those days -- sure hope so!!)
+ good old Vit H wkly for 1st 3 yrs, then triple dosage ev 3 wks for 7 yrs more... The "easy" chemo, right?! Not a walk in the park, but not a freight train coming at 'ya either...
Added Herceptin Nov '98 (6 wks after FDA fast-tracked it for met bc). Stayed w/Vit H till July '08! Now I AM FREE! Humbly and eternally grateful for this life-saving drug! NED since '99 and planning on keeping it that way. To hell w/poor prognosis and nasty stats! STOPPED VIT H JULY '08...! REMAIN STABLE... Eternally grateful...Yes is a world & in this world of yes live (skillfully curled) all worlds ... (e e cummings) EVERY DAY I BEAT MY PREVIOUS RECORD FOR # OF CONSECUTIVE DAYS I'VE STAYED ALIVE. Smile KNOWING you too can be a miracle. Up to me and God now...
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03-28-2015, 09:06 AM
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#13
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Senior Member
Join Date: Nov 2005
Posts: 943
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Re: Is This The End Of Cancer?
Lani, thanks for sharing this is exciting and great news!
__________________
Robin
2002- dx her2 positive DCIS/bc TX Mast, herceptin chemo
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03-28-2015, 09:49 AM
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#14
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Senior Member
Join Date: Sep 2005
Location: Alaska
Posts: 2,018
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Re: Is This The End Of Cancer?
Thanks KDR, Jean and Rhondalea for the link and description - early days with it, but very interesting....
A.A.
P.S. Good to see you, RobinP!
P.P.S. I haven't watched it yet, but one question in particular occurred to me that I thought I'd raise. In regard to using the immune system's response to viruses as a way to battle cancer.... perhaps it may provide some explanation as to why some people with the same genetics as others who develop cancer do not also develop cancer. Perhaps they happened to have gone through having had a virus at some point that wasn't deadly but that "worked" on a cancer they didn't know they had?
__________________
Dx 2002 age 51
bc for granny, aunt, cousin, sister, mother.
ER+/PR+/HER2+++, grade 3
IDC 1.9 cm, some DCIS, Stage 1, Grade 3
Lumpectomy, CAFx6 (no blood boosters), IMRT rads, 1 3/4 yr tamoxifen
Rads necrosis
BRCA 1 & 2 negative
Trials: Early detection OVCA; 2004 low-dose testosterone for bc survivors
Diet: Primarily vegetarian organic; metformin (no diabetes), vitamin D3
Exercise: 7 days a week, 1 hr/day
No trastuzumab, no taxane, no AI
NED
Last edited by AlaskaAngel; 03-28-2015 at 09:58 AM..
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03-28-2015, 10:21 AM
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#15
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Senior Member
Join Date: May 2011
Location: Denver, CO
Posts: 1,427
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Re: Is This The End Of Cancer?
Rhondalea's link didn't work for me (YouTube says the video is "private") but my internet search turned up this commentary on it from Forbes: http://www.forbes.com/sites/matthewh...curing-cancer/
__________________
Amy
_____________________________
4/19/11 Diagnosed invasive ductal carcinoma in left breast; 2.3 cm tumor, 1 axillary lymph node, weakly ER+, HER2+++
4/29/11 CT scan shows suspicious lesions on liver and lungs
5/17/11 liver biopsy
5/24/11 liver met confirmed--Stage IV at diagnosis
5/27/11 Begin weekly Taxol & Herceptin for 3 months (standard of care at the time of my DX)
7/18/11 Switch to weekly Abraxane & Herceptin due to Taxol allergy
8/29/11 CT scan shows no new lesions & old lesions shrinking
9/27/11 Finish Abraxane. Start Herceptin every 3 weeks. Begin taking Arimidex
10/17/11--Brain MRI--No Brain mets
12/5/11 PET scan--Almost NED
5/15/12 PET scan shows progression-breast/chest/spine (one vertebra)
5/22/12 Stop taking Arimidex; stay on Herceptin
6/11/12 Started Tykerb and Herceptin on clinical trial (w/no chemo)
9/24/12 CT scan--No new mets. Everything stable.
3/11/13 CT Scan--two small new possible mets and odd looking area in left lung getting larger.
4/2/13--Biopsy of suspicious area in lower left lung. Mets to lung confirmed.
4/30/13 Begin Kadcyla/TDM-1
8/16/13 PET scan "mixed," with some areas of increased uptake, but also some definite improvement, so I'll stay on TDM-1/Kadcyla.
11/11/13 Finally get hormone receptor results from lung biopsy of 4/2/13. My cancer is no longer ER positive.
11/13/13 PET scan mixed results again. We're calling it "stable." Problems breathing on exertion.
2/18/14 PET scan shows a new lesion and newly active lymph node in chest, other progression. Bye bye TDM-1.
2/28/14 Begin Herceptin/Perjeta every 3 weeks.
6/8/14 PET "mixed," with no new lesions, and everything but lower lungs improving. My breathing is better.
8/18/14 PET "mixed" again. Upper lungs & one spine met stable, lower lungs less FDG avid, original tumor more avid, one lymph node in mediastinum more avid.
9/1/14 Begin taking Xeloda one week on, one week off. Will also stay on Herceptin and Perjeta every three weeks.
12/11/14 PET Scan--no new lesions, and everything looks better than it did.
3/20/15 PET Scan--no new lesions, but lower lung lesions larger and a bit more avid.
4/13/15 Increasing Xeloda dose to 10 days on, one week off.
7/1/15 Scan "mixed" again, but suggests continuing progression. Stop Xeloda. Substitute Abraxane every 3 weeks starting 7/13.
10/28/15 PET scan shows dramatic improvement everywhere. All lesions except lower lungs have resolved; lower lungs noticeably improved.
12/18/15 Last Abraxane. Continue on Herceptin and Perjeta alone beginning 1/8/16.
1/27/16 PET scan shows cancer is stable.
5/11/16 PET scan shows uptake in some areas that were resolved on the last two scans.
6/3/16 Begin Kadcyla and Tykerb combination
6/5 - 6/23 Horrible diarrhea from K&T together. Got pneumonia.
7/15/16 Begin Kadcyla only every 3 weeks.
9/6/16 Begin radiation therapy on right lung lesion that caused the pneumonia.
10/3/16 Last of 12 radiation treatments to right lung.
11/4/16 Huffing and puffing, low O2, high heart rate, on tiniest bit of exertion. Diagnosed as radiation pneumonitis. Treated with Prednisone.
11/11/16 PET scan shows significant improvement to radiated part of right lung BUT a bunch of new lung lesions, and the bone met is getting worse.
11/22/16 Begin Eribulin and Herceptin. H every 3 weeks. E two weeks on, one week off.
3/6/17 Scan shows progression in lungs. Bone met a little better.
3/23/17 Lung biopsy. Tumor sampled is ER-, PR+ (5%), HER2+++. Getting Herceptin and Perjeta as a maintenance treatment.
5/31/17 Port placement
6/1/17 Start Navelbine & Tykerb
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