Some new omega three six trials and one old

[R.B.]

The first trial you have seen before I think the rest a new here.

Just in case you have lost sight of the omega threes and sixes!!

(also posted to Greek Diet thread to try and keep things in one place)

RB



http://www.ncbi.nlm.nih.gov/sites/en...ubmed_RVDocSum

"These findings reveal that the omega-3 PUFA ALA suppresses overexpression of HER2 oncogene at the transcriptional level, which, in turn, interacts synergistically with anti-HER2 trastuzumab- based immunotherapy. ii) Our results molecularly support a recent randomized double-blind placebo-controlled clinical trial suggesting that ALA may be a potential dietary alternative or adjunct to currently used drugs in the management of HER2-positive breast carcinomas. iii) Considering our previous findings demonstrating the HER2 upregulatory actions of the omega-6 PUFA linolenic acid (LA; 18:2n-6) and the HER2 down-regulatory actions of the omega-3 PUFA docosahexaenoic acid (DHA; 22:6n-3) and of the omega-9 monounsaturated fatty acid oleic acid (OA; 18:1n-9), it is reasonable to suggest that a low omega-6/omega-3 PUFA ratio and elevated MUFA levels, the two prominent fat features of the Mediterranean diet, should be extremely efficient at blocking HER2 expression in breast cancer cells."


http://www.ncbi.nlm.nih.gov/sites/en...ubmed_RVDocSum

"our results indicate that (n-3) FA modify the lipid composition of membrane rafts and alter EGFR signaling in a way that decreases the growth of breast tumors."

http://www.ncbi.nlm.nih.gov/sites/en...ubmed_RVDocSum

"Use of canola oil instead of corn oil in the diet may be a reasonable means to increase consumption of n-3 fatty acids with potential significance for slowing growth of residual cancer cells in cancer survivors."

http://www.ncbi.nlm.nih.gov/sites/en...ubmed_RVDocSum

"In conclusion, we showed that erythrocyte compositions of specific fatty acids derived from fish intake, as biomarkers, are associated with lower risk of breast cancer, but further studies are needed to investigate mechanisms linked to the etiology. (c) 2007 Wiley-Liss, Inc."

http://www.ncbi.nlm.nih.gov/sites/en...ubmed_RVDocSum

"Since DHA influences the product of a major tumour suppressor gene, this finding may contribute to the observation that high-fish consumption reduces the risk of breast cancer."

http://www.ncbi.nlm.nih.gov/sites/en...ubmed_RVDocSum

"Our results support the premise that DHA and genistein exert complementary actions whilst genistein is antagonistic to AA for controlling PGE(2) production as well as invasiveness of MDA-MB-231 cells in culture by modulating the level of NFkappaB expression."

[R.B.]

As per previous posts what you eat influences your gene expression.

In a previous trial on skeltal muscle genes diffferntially expressed included HER 2 and BRAC.

They are influential these omega three and six fats !!!

RB




http://www.ncbi.nlm.nih.gov/sites/en...ubmed_RVDocSum

Differential effects of omega-3 and omega-6 Fatty acids on gene expression in breast cancer cells.
Hammamieh R, Chakraborty N, Miller SA, Waddy E, Barmada M, Das R, Peel SA, Day AA, Jett M.

Division of Pathology, Walter Reed Army Institute of Research, 503 Robert Grant Road, Silver Spring, MD 20910, USA.

Essential fatty acids have long been identified as possible oncogenic factors. Existing reports suggest omega-6 (omega-6) essential fatty acids (EFA) as pro-oncogenic and omega-3 (omega-3) EFA as anti-oncogenic factors. The omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), inhibit the growth of human breast cancer cells while the omega-6 fatty acids induces growth of these cells in animal models and cell lines. In order to explore likely mechanisms for the modulation of breast cancer cell growth by omega-3 and omega-6 fatty acids, we examined the effects of arachidonic acid (AA), linoleic acid (LA), EPA and DHA on human breast cancer cell lines using cDNA microarrays and quantitative polymerase chain reaction. MDA-MB-231, MDA-MB-435s, MCF-7 and HCC2218 cell lines were treated with the selected fatty acids for 6 and 24 h. Microarray analysis of gene expression profiles in the breast cancer cells treated with both classes of fatty acids discerned essential differences among the two classes at the earlier time point. The differential effects of omega-3 and omega-6 fatty acids on the breast cancer cells were lessened at the late time point. Data mining and statistical analyses identified genes that were differentially expressed between breast cancer cells treated with omega-3 and omega-6 fatty acids. Ontological investigations have associated those genes to a broad spectrum of biological functions, including cellular nutrition, cell division, cell proliferation, metastasis and transcription factors etc., and thus presented an important pool of biomarkers for the differential effect of omega-3 and omega-6EFAs.

PMID: 16823509 [PubMed - indexed for MEDLINE]

[kimber]

Great job R.B.! Thank you very much for your continued diligence on providing such valuable information. - kim