Has anyone had a her2neu positive recurrence after initally being her2neu negative??

[cath_ob]

Hello...I'm new here.

I wanted to know if anyone had a her2neu positive recurrence after initally being her2neu negative??

My original breast tumor tested ER/PR postive and her2neu negative by IHC. NO FISH was done.

The tests were done at MD Anderson. Apparently they do not do a FISH test unless IHC is 1 or more. hmmmmm.

I had FAC and Taxol and finished chemo in 12/05. Then had radiation and started Tamoxifen

Just found out I have advanced mets to bone, liver and lung.

I am demanding a liver biopsy to retest the tumor to ensure it still has the same features.

Per several oncologists...no one seems to see people with tumors that change to her2neu positive.

Has this happened to anyone here?

Thanks for any responses.

Cathy