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05-02-2006, 08:25 AM
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#1
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Member
Join Date: May 2006
Location: Malaysia
Posts: 8
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Infusion underdose-please help
Dear all,
This is my first time posting, eventhough I have been reading the posts since early last year. This site is my refuge when I am feeling really down..
I am on 30 minutes Herceptin infusion on every 3 weeks cycle for a year (6 mg/kg dosage). Unfortunately, last week, on my 12th session, the herceptin given was underdose ie only 172 mg.
I am supposed to get 330mg per cycle. I managed to maintain my weight to 55kg each time.:-) or :-)??.
The nurses realised their mistake after finishing the infusion.
My oncologist suggested that I am to be given higher dosage of 488 mg for my next appointment.This is to compensate for low dosage last time.
But he didn't know for sure wether his suggestion is okay or not. When I asked him if that last infusion is good, he appeared to be at a loss.
My next treatment is in the middle of next month, and I am scared of what that bigger dosage might do to me. He cautioned me to be on alert for side effects.
Thank you for any info. I appreciate it.
Cheers,
Hannah
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D'xd in Feb 2005,Tumor 5cm,Her2+++,(ER/PR-),1/7 nodes +ve,had neoadjuvant AC therapy, mastectomy,15 RT sessions, started Herceptin in Sept 05,
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05-02-2006, 10:14 AM
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#2
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Senior Member
Join Date: Mar 2006
Location: Northern Va
Posts: 84
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Hannah,
I weigh a little more than you do. My loading dose was 526mg. I broke out in a rash from that first one. Started itching two days later, then I realized I had a rash on my trunk. So then they tried 25mg, then 138mg, and so far I haven't had a rash. I go tomorrow and will see if they give me the one week dose (138) or a two week dose (276). My normal three week dose is supposed to be around 420. But am now losing weight since I am no longer on the steroids. Thank goodness.
There is a link on this site that will take you to the manufactures website and all the side effects are listed.
Hope this was helpful.
__________________
Cheryl
Stage II, Grade III, ER+/PR-, Her2 3.0 amplified, N 0/5, dx 9/05, 39 yrs
Right Mastectomy, immediate tram flap reconstruction
4 AC, 4 Taxotere finished 3/15/06
Currently on Herceptin and Tamoxifen
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05-02-2006, 10:19 AM
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#3
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Webmaster
Join Date: Feb 2005
Location: Home of the "Flying Tomato"
Carlsbad, CA
Posts: 2,036
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Hannah,
If it is not too inconvienient, why not ask to get your next infusion a week early?
Regards
Joe
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05-02-2006, 10:43 AM
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#4
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Member
Join Date: Sep 2005
Location: London, England
Posts: 24
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Underdose
My wife's Onc was the UK head of the HERA trial. Half way through treatment we went on an extended holiday and he seemed quite calm about missing a session or extending the gaps as he explained Herceptin has a long half life - so the underdose may not be a cause for undue alarm.
The higher dose on the next visit or bringing the session forward a week sounds like a good idea.
John L
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05-02-2006, 05:13 PM
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#5
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Senior Member
Join Date: Oct 2005
Posts: 476
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Having exposed to many medical articles about dosages, I feel that you should not increase your dosage of infusion. The risk of high dose side effects is not worthwhile. Just as the previous message indicated, the half life of the medication is rather high and the effectiveness will not significantly decrease by one under fusion. You should do well, kiddo.
Ann
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05-02-2006, 05:56 PM
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#6
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Member
Join Date: May 2006
Location: Malaysia
Posts: 8
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Dear Cheryl,Joe,John and Ann and others,
Thanks, thanks, thanks. I am the only CA patient under the herceptin therapy in this hospital. I am taking it upon the recomendation of my surgeon who has left for England last December.Sob..sob..My present onco and his team doesnt support me using the drug as "herceptin for early stage patients is still in clinical trial and also I should use it for later when I am in an advanced stage-if it recur". Those are their opinions.
So I am really on my own here..
Thanks again.
Cheers,
hannah
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