I think the gold standard for determining Her2 status is FISH analysis. If the FISH says Her2-, I'd be inclined to think that is correct.You also mentioned that the path report of other biological markers of the tumor were "low S phase (more slowly dividing) & diploid (normal number of chromosomes)vs. a high S phase -very rapidly dividing- & anueploid-abnormal or too many chromosomes." Her2+ tumors are typically aneuploid with a high S phase.
If you're still concerned, ask your onc to do a FISH analysis on the tumor, so that you can compare the tumor FISH results to the core biopsy FISH results, rather than the two different test types.
Consider it GOOD NEWS to be Her2-, diploid & low S phase!!That means the tumor was slower growing, less aggressive.I am so glad to have Herceptin and will continue to take it as long as they will give it to me, but I would trade my Her2+++, Grade 3, poorly differentiated, aneuploid & S-Phase 23%(!!!)in a heartbeat!
Take good care,
Jessica
ps-if they do a FISH analysis on the tumor and your are her2+, i hope you will look into getting into clinical trial for early stage, her2+ and get on herceptin!
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