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Old 04-06-2006, 11:39 AM   #1
Nicola
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Join Date: Dec 2005
Location: King & Queen County Virginia
Posts: 59
Herceptin & Lapitinib

Hi Marily,

I experience severe diarrhea with Lapatinib, Herceptin and Taxol. I also broke out in a rash across my shoulders, upper back and arms. The rash only itched slightly and it went away in a matter of a couple of days, I used Benadryl for the itching. I also experience a lot of joint pain in my legs and mild neuropathy in my shins and feet. I have nausea on and off but the worst part is the fatigue.

I have to stay on Immodium to keep the diarrhea in check. I probably take two Immodium's every other day and by doing so it keeps me pretty normal.

My very first treatment was the worst. I had terrible chills and body aches and was nauseated but my second treatment went much better.

I am doing very well over all and I just had my second set of CT's done and will have the results tomorrow. I will be sure to post the results once I have them. The first set of CT's I had done were very promising. The two largest tumors in my liver had shrunk by 20% after only 7 treatments. I am very excited about this combination of drugs and I can't wait until Lapatinib is more readily available to others.

If you have any other questions please feel free to e-mail me anytime.

Big Hugs,
Nicola
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Old 04-06-2006, 02:04 PM   #2
Cathya
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Join Date: Sep 2005
Location: Ontario, Canada
Posts: 752
Esther;

There is a GlaxoSmithKline Breast Cancer Study which I applied to that involves either Lapitinib as a single agent or in combination with another drug. Both are taken orally and you must present yourself to the hospitals every 4 weeks. Apparently this is open and not closing soon. I did not qualify as (thank goodness) as I have had no recurrence You must have active disease. I wanted to take this drug as I have been taken off herceptin so we have agreed that, although hopefully we will never speak again (lol) my file will remain in their books and if I do have a recurrence I will be put forward as a potential candidate. I live in the north so spoke to a woman at the Rochester NY address. Acurian forwarded my name to them after I found the link that Joe put on the site and completed the application. She responded very quickly and I would suggest that if think you would qualify (or not if you want to have the potential contact) complete the application.

Here is the information Joe posted:

We previously sent you an e-mail about three (3) breast cancer clinical research studies (clinical trials) being conducted in your area that may be of interest to you. The studies are evaluating the safety and effectiveness of an investigational oral drug, GW572016, for the treatment of advanced or metastatic, Stage III or IV, breast cancer in women. If you have already called about these clinical trials, there is no need to call again. However, if you have not called, we wanted to give you another opportunity to participate in these clinical trials.

Below are some of the criteria that you must meet to be eligible for this study:
  • Female, at least 18 years of age
  • Diagnosed with Stage III or Stage IV breast cancer
  • Able to swallow and retain oral medications
  • Not currently pregnant or nursing.
Additional criteria will be evaluated to determine your eligibility.

All qualified study participants will receive the investigational drug at no cost. The length of study participation is dependent on how each woman and her tumor(s) respond to the study drug(s).

If these studies interest you and you wish to find out if you may be eligible to participate, we invite you to contact Acurian for pre-screening by clicking here or calling toll free 1-800-563-6118.

About Acurian
Acurian is a company that specializes in education and awareness campaigns for clinical research studies. They are working with the sponsor of these studies to coordinate the pre-screening and referral of women to the research sites for further evaluation and consideration for participation in these breast cancer research studies.

Acurian's Privacy Statement:
Your responses to the pre-screening questions will be kept confidential and will only be shared with the research study doctor's staff to help them determine your final eligibility for this study. This de-identified data may also be shared with the study sponsor, and its representatives, should you be enrolled. Your information will be saved at Acurian only until the study is complete; then it will be destroyed. The decision to participate will be yours alone and you can change your mind at any time.

To see if you are eligible and get more information on the clinical trials, click here
http://www.cancerprofiler.nexcura.com/go/acurianbreast
or call toll-free 1-800-563-6118.
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Old 05-04-2006, 01:40 AM   #3
Marily
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Join Date: Mar 2006
Location: Aurora CO
Posts: 75
Nicola, thank you for your information on Lapatinib. I am watching with alot of interest what happens with this drug and when it will be available. I am so glad you are doing well on it.
I have been able to go back on Herceptin with the help of Iv Benedryl, a double dilution of the drug and being given it over 2 1/2 hours. But it is good to know if I have further problems there is another option.
Hugs and thank you for the information.
Marily
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