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Old 03-12-2006, 06:08 AM   #1
mkrny
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herceptin during WBR

I'm sure this is a repeat but are there studies showing benefit of taking herceptin during WBR. Rad oncs have told us they don't want my wife to get any herceptin (or chemo current cocktail is navelbine, xeloda plus the herceptin) during WBR.

Christine mentioned to us herceptin during WBR should be beneficial in fact I think she said WBR presents an opportunity for herceptin to penetrate the blood brain barrier. The fog is clearing a little now that we have a plan of treatment we selected and I want to clarify some finer points on treatment details I should push for that I may have misinterpreted in the daze that followed our scan news from 3/2.
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Old 03-12-2006, 06:14 AM   #2
tousled1
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This may sound like a stupid question but I'm new here and learning a lot. Can you tell me what WBR means. Thanks.
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Kate
Stage IIIC Diagnosed Oct 25, 2005 (age 58)
ER/PR-, HER2+++, grade 3, Ploidy/DNA index: Aneuploid/1.61, S-phase: 24.2%
Neoadjunct chemo: 4 A/C; 4 Taxatore
Bilateral mastectomy June 8, 2006
14 of 26 nodes positive
Herceptin June 22, 2006 - April 20, 2007
Radiation (X35) July 24-September 11, 2006
BRCA1/BRCA2 negative
Stage IV lung mets July 13, 2007 - TCH
Single brain met - August 6, 2007 -CyberKnife
Oct 2007 - clear brain MRI and lung mets shrinking.
March 2008 lung met progression, brain still clear - begin Tykerb/Xeloda/Ixempra
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Old 03-12-2006, 06:18 AM   #3
mkrny
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WBR = Whole Brain Radiation

No problem, WBR = Whole Brain Radiation
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Old 03-12-2006, 06:23 AM   #4
tousled1
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Thanks. Hopefully I will learn all the acronyms one day.
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Kate
Stage IIIC Diagnosed Oct 25, 2005 (age 58)
ER/PR-, HER2+++, grade 3, Ploidy/DNA index: Aneuploid/1.61, S-phase: 24.2%
Neoadjunct chemo: 4 A/C; 4 Taxatore
Bilateral mastectomy June 8, 2006
14 of 26 nodes positive
Herceptin June 22, 2006 - April 20, 2007
Radiation (X35) July 24-September 11, 2006
BRCA1/BRCA2 negative
Stage IV lung mets July 13, 2007 - TCH
Single brain met - August 6, 2007 -CyberKnife
Oct 2007 - clear brain MRI and lung mets shrinking.
March 2008 lung met progression, brain still clear - begin Tykerb/Xeloda/Ixempra
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Old 03-15-2006, 10:55 AM   #5
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I took Herceptin throughout my wbr. All I can tell you is it has been over a year with no recurrences in the brain. For what that's worth.
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