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Old 11-15-2005, 07:02 PM   #1
jojo
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Join Date: Sep 2005
Location: San Francisco Bay Area in California
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Question Fatigue -- common side effect of Xeloda??

For those of you who have been on Xeloda, did you have fatigue while on it? If so, what dosage? Thanks.
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Blessings & Peace,
~jojo~

1st Dx: May '03 at age 35
Stage 3b
6cm IDC tumor
17/18 + nodes
Neoadjuvant: 4x A/C dose dense; 12x weekly Taxol & weekly Herceptin
Left Mastectomy: Nov '03
27x Rads
Stage 4 since June '04
Still on maintenance Herceptin since the very beginning
Currently on Abraxane (3 weeks / 1 week off)
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Old 11-16-2005, 01:22 AM   #2
Lyn
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Smile

Hi there, that is why I must be tired all the time, I thought it was my heart again. I am on 1000mg a day, 2 weeks on 2 weeks off, indefinately with cyclosphosomide tablets for remaining breast mets, skin and mass. I hate getting up in the morning and during the day all of a sudden I just want to lie down.


Love & Hugs Lyn
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Old 11-16-2005, 07:57 AM   #3
pattyz
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jojo, I'm on just 2000 mg a day. This is my fourth cycle of two weeks on/two off. I haven't really noticed any fatigue at this level. But I do notice a wax and wane energy level. ? On OCCATION I feel a bit 'off'... and later in the evening have fallen asleep in chair around dinner time. But that's it. Plus, I'm OLD!! LOL!

hugs,
patty
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Old 11-16-2005, 09:47 AM   #4
Julie2
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Jojo,

when I had xeloda I didn't experience any fatigue. My dosage was 1650mg two times daily. Two weeks on and one week off. But my red and white blood count was mariginally low.

Julie
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Diagnosed in Sept 2004 while pregnant with the second child. Stage 3b, tumor 4.5cm, 4 auxillary and supraclav node positive. Her2+++ FISH 9.4 and er-,pr-.
Had dose dense neoadjuvant AC,Taxol then mastectomy,radiation+xeloda+Herceptin.
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Old 11-16-2005, 11:01 AM   #5
Cindi
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Jojo,

No fatigue for me while I was on Xeloda. I had 1500 mg twice a day for 6 months.

Cindi.
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Old 11-16-2005, 11:09 AM   #6
Pam P
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I dont think I experience extra fatigue from xeloda, just the normal tiredness of working full time, etc. At least it's not as noticable as it was on prior chemo drugs. I take 2000/mg in a.m. & 1500 in p.m. I've been on it since end of july. Right now my biggest s/e have been sore/swollen/dry fingers & toes. My blood counts have stayed normal. Pam
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Old 11-16-2005, 05:21 PM   #7
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Dear JoJo- I have been on 3000mg a day for about 6 months now. I think the fatigue I feel comes from losing all the nutrients with all the diahreah I have.(About 3 or 4 times a week right before my break) I sually take a nap in the afternoon, but other than that I just plug away. God Bless- Cathy
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Old 11-16-2005, 11:10 PM   #8
jojo
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Cool Hmmm....

Hmm.... that's quite interesting... I notice that the H/F syndrome seems to be more recurrant rather than the fatigue.

I don't have big problems with HF, just skin colorings only. I can't help but wonder if fatigue is attributed to my increased dosage of Xeloda. Started out on 2,500mg, just increased now on 3,000mg.

My fatigue is quite similar & close to the fatigue I had while on original chemo from 2 years ago.
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Blessings & Peace,
~jojo~

1st Dx: May '03 at age 35
Stage 3b
6cm IDC tumor
17/18 + nodes
Neoadjuvant: 4x A/C dose dense; 12x weekly Taxol & weekly Herceptin
Left Mastectomy: Nov '03
27x Rads
Stage 4 since June '04
Still on maintenance Herceptin since the very beginning
Currently on Abraxane (3 weeks / 1 week off)
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Old 11-18-2005, 08:46 PM   #9
Amy
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Yes, I'm exhausted..... and I'm getting real sick and tired of it. I've got an interesting schedule as far as my dosage goes. Since my H/F syndrom is causing me some trouble, my Onc changed my dosage to... 4000 mg/day for 8 days and then 3500mg for the remaining 6 days...then a week off. This is my 4th round. We'll see how things go.

My thoughts and prayers to you all....Amy
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Old 11-19-2005, 08:50 AM   #10
jojo
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Cool Hi there, Amy! :-)

Amy,

This is really interesting as your Xeloda schedule goes. When did you begin the revised dosage?

I am not quite sure why I feel fatigued at times. I have yet to find out my Echo result, I took that last week, and I am seeing my onc on Tues after Thanksgiving Weekend.

Let's keep in touch & compare notes. I really hope that Xeloda is working for you!! <crossing fingers AND toes!>
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Blessings & Peace,
~jojo~

1st Dx: May '03 at age 35
Stage 3b
6cm IDC tumor
17/18 + nodes
Neoadjuvant: 4x A/C dose dense; 12x weekly Taxol & weekly Herceptin
Left Mastectomy: Nov '03
27x Rads
Stage 4 since June '04
Still on maintenance Herceptin since the very beginning
Currently on Abraxane (3 weeks / 1 week off)
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Old 11-19-2005, 01:12 PM   #11
pattyz
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jojo...

jojo...
going through some of my 'saved stuff' today and found this pretty comprehensive guide to the sides of Xeloda. I really believe much is contollable through dosage etc. That is the 'latest' in findings anyway.

<<Possible side effects
Each person’s reaction to chemotherapy is unique. Some people have very few side effects, while others may experience more. The side effects described in this information will not affect everyone who is given capecitabine, and may be different if you are having more than one chemotherapy drug.

We have outlined the most common side effects and those which are less common, so that you can be aware of them if they occur. However, we have not included those that are very rare and therefore extremely unlikely to affect you. If you notice any effects which you think may be due to the drug but which are not listed in this information, please discuss them with your doctor or chemotherapy nurse.

Nausea (feelings of sickness) and vomiting This is usually mild. There are now very effective anti-sickness drugs to prevent or reduce nausea and vomiting. If you do feel sick, tell your doctor, who can prescribe anti-sickness drugs.

Sore mouth and taste change Your mouth may become sore or you may notice small ulcers during this treatment. Drinking plenty of fluids and cleaning your teeth regularly and gently with a soft toothbrush can help to reduce the risk of this happening. Tell your doctor if you have any of these problems, as special mouthwashes and medicines to prevent or clear any mouth infection can be prescribed.

You may also notice that your food tastes different. Normal taste will come back after the treatment finishes.

Diarrhoea This can be quite severe but can usually be controlled with medicines. If you have diarrhoea more than 4–6 times a day, contact your specialist for advice immediately. You may be advised to stop taking capecitabine; however, it is often possible to restart the treatment at a lower dose. It is important to drink plenty of fluids if you have diarrhoea.

Abdominal pain and constipation It may help to drink plenty of fluids, eat a high-fibre diet and take gentle exercise. Sometimes you may need to take medicines to stimulate your bowel. These can be prescribed by your doctor.

Loss of appetite A dietitian or specialist nurse at your hospital can give advice and tips on boosting appetite, coping with eating difficulties and maintaining weight.

Skin changes Soreness and redness or darkening of the palms of the hands and soles of the feet (sometimes known as palmar plantar syndrome or hand-foot syndrome) can occur. You may be prescribed vitamin B6 (pyridoxine), which can help to reduce this. A rash, and dry or itchy skin, may also occur. If you notice this, let your specialist know.

Tiredness and a general feeling of weakness It is important to allow yourself plenty of time to rest.

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Less common side effects
Lowered resistance to infection Capecitabine can reduce the production of white blood cells by the bone marrow, making you more prone to infection. This effect can begin about seven days after treatment has been given and usually reaches its lowest point 10–14 days after starting the chemotherapy. Your blood cells will then increase steadily and will usually have returned to normal before your next course of chemotherapy is due.

Contact your doctor or the hospital straightaway if:

Your temperature goes above 38ºC (100.5ºF)
You suddenly feel unwell (even with a normal temperature)
You will have a blood test before having more chemotherapy, to make sure that your cells have recovered. Occasionally it may be necessary to delay your treatment if your blood count is still low.

Bruising or bleeding Capecitabine can reduce the production of platelets (which help the blood to clot). Let your doctor know if you have any unexplained bruising or bleeding.

Anaemia (low number of red blood cells) While having treatment with capecitabine you may become anaemic. This may make you feel tired and breathless.

Hair loss Hair loss is uncommon but your hair may thin, or occasionally be lost completely. If this happens it usually begins about 3–4 weeks after starting treatment, although it may occur earlier. It is temporary, and the hair will start to regrow once the treatment ends.

Headaches and dizziness Tell your doctor if you have headaches or feel dizzy and lightheaded while taking capecitabine.

Increased production of tears This may be caused by capecitabine, and is temporary.>>

hugs,
patty
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