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Re: ER-/PR- HER2 staging poll
Dianne, I don't know that it's specific to Canada, that ER/PR lacks accuracy. My pathology (at a community hospital in California) was ER/PR negative on a large axillary node that was done first, then 5%/1% on the occult breast tumor. It took me two years to gather the gumption and figure out how to have that rechecked. I sent my slides and blocks to Baylor (Texas) for a second pathology and once I hooked up with them, the rest was easy (and inexpensive). Maybe that's an option for you?
Debbie Laxague
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3/01 ~ Age 49. Occult primary announced by large (6cm) axillary node, found by my husband.
4/01 ~ Bilateral mastectomies (LMRM, R elective simple) - 1.2cm IDC was found at pathology. 5 of 11 axillary nodes positive, largest = 6cm. Stage IIIA
ERPR 5%/1% (re-done later at Baylor, both negative at zero).
HER2neu positive by IHC and FISH (8.89).
Lymphovascular invasion, grade 3, 8/9 modified SBR.
TX: Control of arm of NSABP's B-31 adjuvant Herceptin trial (no Herceptin, inducing a severe case of Herceptin-envy): A/C x 4 and Taxol x 4 q3weeks, then rads. Raging infection of entire chest after small revision of mastectomy scar after completing tx (significance unknown). Arimidex for two years, stopped after second pathology opinion.
2017: Mild and manageable lymphedema and some cognitive issues.
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