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Old 08-03-2010, 01:43 PM   #1
CourtneyL
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Join Date: Aug 2008
Location: San Francisco
Posts: 260
Re: 4th Gamma Knife

Flossie - I saw Hope Rugo at a seminar a while back and, although she didn't mention this patient by name specifically, I thought she might be talking about her. She said the patient who had multiple brain mets was now on a chemo called Temodar (Temozolomide) - which, as far as I know, has been FDA approved here in the US for quite a while. It is known to cross the blood brain barrier. Another one to ask your doctors about is Xeloda (Capcetabine) - also thought to cross the BBB. It works synergistically with Tykerb (Lapatinib).
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4/17/08: Dx Stage IV at age 30 - extensive mets to liver, lungs, and bones. Er/Pr-, Her2+++
April 08-Aug 08:Taxotere, Cytoxan, Herceptin, Zometa - complete response!
Sept 08-Dec 08: Herceptin +Zometa for maintenance.

Jan 09-April 09: Brain mets. Add Tykerb. Watch and wait.
April 09: Gamma Knife 10 brain mets, add Xeloda.
Sept 09: Gamma Knife to 1 brain met.
Nov 09- April 10: Lung progression, add Gemzar to Herceptin, Zometa.
May 10- Sept 10: HER2 Vaccine Trial

Sept 10: Add Tykerb for more brain mets.
Oct 10: Gamma Knife to 7 brain mets.
Dec 10: Switch from Zometa to Denosumab.
Jan 11: Gamma Knife to 3 brain mets.
March 11: Gemzar/Herceptin for lung/bone progression.
April 11: More brain mets - Intrathecal Herceptin
June 11: Ixempra/Herceptin for lung, soft tissue progression.
Aug 11: Gamma Knife
Sep 11: Abraxane/Herceptin
Future: NED

Send me a PM if you'd like to follow my journey on Caringbridge.
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Old 08-03-2010, 01:55 PM   #2
Flossie
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Join Date: Aug 2010
Posts: 7
Re: 4th Gamma Knife

Hi Courtney, Thanks for that info. I will investigate Temodar. I did have Capecitibine last year and it did work well with the Lapatinib I have to say it kept the critters at bay for quite a while. I forgot to put it on my signature (doh am still learning!) Keep forgetting the drugs I have had, must be all that zapping!

Hope all goes well for you with your vaccine!
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Flossie

Jan 2006 DX large lump in armpit. 2 x 5mm tumors in left breast.
FEC for 6 cycles
Aug 2006 Mastectomy + Herceptin 1 yr + Tamoxifen.
Aug 2007 Lat Dorsi Reconstruction + Tamoxifen
Aug 2008 3cm brain met gamma knife +mets in rib and neck 5 x RT/Herceptin/Arimidex/Clodronate.
Apr 2009 11 mets Gamma Knife/Capecitibine/Tykerb
Mar 2010 3 mets Gamma Knife/Zometa/Femara/Tykerb
Mar 2010 Pet Scan all clear continue Tykerb
Aug 2010 12 mets + Zometa/Femara/Tykerb
Jan 2010 5 Years!!
Mar 2010 - Gamma Knife 7 mets
Aug 2010 - Gamma Knife 12 mets
Jan 2011 - 6 Years!
Mar 2011 - Gamma Knife
Mar 2011 - Taxotere
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