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01-15-2010, 10:50 AM
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#1
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Senior Member
Join Date: Mar 2009
Location: Pennsylvania
Posts: 38
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Another Reaction?!
Hi Everybody,
Well, I had yet another heart racing reaction.... Back when I was doing chemo twice I had reactions during the premeds and we ended up blaming it on the Decadron. Well,this time there was no decadron involved, only Herceptin. It was about 25 min into the infusion and my heart rate went up to 130, it slowed a bit and then was at maybe 115 and then it came back down. They stopped the Herceptin gave me Benadryl and did an EKG and a muga, which all came back fine.
I have been getting Herceptin since May. First I was on a triple dose and then we went on weekly and just lately I wanted to be switched back to a triple dose to facilitate a trip we are going on. SO I had been off of Herceptin for about 1 month as we tried to get on schedule with the triple dose.
Anyway, has anybody ever experienced this? Any thoughts as to what might be going on? I'm thinking that maybe a whole year on Herceptin isn't necesssary considering my stage 2 grade 2 dx.
They want me to see a Heart group to make sure all is well.
Thanks everyone, its great to get advice from those who have "been there"
Blessings,Darlene
__________________
2-17-09 biopsy
2-20-09 BC diagnosis @ age 28- 1.1cm by ultrasound, grade II, Her2+++, ER+5%, PR-
3-18-09 lumpectomy, sentinel node biopsy
Actual tumor 4-5 cm, positive margins. Nodes negative.
4-7-09 Re-excision, more positive margins
4-21-09 Right Mastectomy
5-18-09 TCH every 3 weeks
7-24-09 Chemo finished, continue Herceptin
12-8-09 PET Scan - NED!!
Jan.2010 8 months Herceptin done
No rads
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01-15-2010, 11:42 AM
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#2
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Senior Member
Join Date: Jun 2007
Posts: 2,210
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Re: Another Reaction?!
It is always a good idea to get a second opinion. In this case seeing the cardiac specialists.
Maybe they are administering the Herceptin too fast? Or you are reacting to some component of the IV? I have no idea. But I do think that discontinuing the Herceptin should be the very last resort!
Hoping you figure it out. Keep the faith.
__________________
Bonnie
Post menopause
May 2007 Core biopsy, Rt breast
ER+, Pr-, HER2 +++, Grade 3
Ki-67: 90%
"suspicious area" left breast
Bilateral mastectomy, (NED on left) May 2007
Sentinel Node Neg
Stage 1, DCIS with microinvasion, 3 mm, mostly removed during the biopsy....
Femara (discontinued 7/07) Resumed 10/07
OncoType score 36 (July 07)
Began THC 7/26/07 (d/c taxol and carboplatin 10/07)
Began Herceptin alone 10/07
Finished Herceptin July /08
D/C Femara 4/10 (joint pain/trigger thumb!)
5/10 mistakenly dx with lung cancer. Middle rt lobe removed!
Aromasin started 5/10
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01-15-2010, 12:03 PM
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#3
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Senior Member
Join Date: Jan 2007
Location: Thornhill, Ontario
Canada
Posts: 2,320
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Re: Another Reaction?!
Hi Darlene,
How long do they take to do the infusion ? Many people have 30 minute infusions, but I had mine slowed to 60 minutes. You could ask the nurses to try this, maybe even over 90 minutes, to see if a slower infusion helps the situation at all. I would see the Heart Group as well.
all the best
caya
__________________
ER90%+/PR 50%+/HER 2+
1.7 cm and 1.0 cm.
Stage 1, grade 2, Node Negative (16 nodes tested)
MRM Dec.18/06
3 x FEC, 3 x Taxotere
Herceptin - every 3 weeks for a year, finished May 8/08
Tamoxifen - 2 1/2 years
Femara - Jan. 1, 2010 - July 18, 2012
BRCA1/BRCA2 Negative
Dignosed 10/16/06, age 48 , premenopausal
Mild lymphedema diagnosed June 2009 - breast surgeon and lymph. therapist think it's completely reversible - hope so.
Reclast infusion January 2012
Oopherectomy October 2013
15 Years NED!!
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01-15-2010, 01:43 PM
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#4
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Senior Member
Join Date: Mar 2009
Location: Pennsylvania
Posts: 38
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Re: Another Reaction?!
They were infusing a triple dose over 60 min.Maybe slower would be the key. It is a bit faster than I was recieving it. I was getting a single dose over 30 min.
Thanks for replying!
Darlene
__________________
2-17-09 biopsy
2-20-09 BC diagnosis @ age 28- 1.1cm by ultrasound, grade II, Her2+++, ER+5%, PR-
3-18-09 lumpectomy, sentinel node biopsy
Actual tumor 4-5 cm, positive margins. Nodes negative.
4-7-09 Re-excision, more positive margins
4-21-09 Right Mastectomy
5-18-09 TCH every 3 weeks
7-24-09 Chemo finished, continue Herceptin
12-8-09 PET Scan - NED!!
Jan.2010 8 months Herceptin done
No rads
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01-15-2010, 04:28 PM
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#5
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Senior Member
Join Date: Dec 2008
Location: Southern Indiana
Posts: 455
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Re: Another Reaction?!
This has never happened to me. I do take a med for my heart because I had a drop in muga. It went up from the meds and I lost weight and it went up higer that before dx. Your scores will go up and down thought.
I think it is wise to go to a heart group.
I get my Herceptin every three weeks and it takes 90 minutes. They weigh me every time and know I get 500 units of however they measure it.
Hope this helps.
Blessings and hugs, I love your pictures, Alice
__________________
Alice
04/08 age 50 III IBC Her2+++ ER/PR-8cm 14/14 Double M, Body and Brain CT/PET clear, ? on spine,Muga 53
06/08, 4 A/C, Neulasta
08/08, Herceptin/tax 12 every week
10/08, CT/PET clear, ? on pelvis, hips, MUGA 43, started Enalaprial for heart, Herceptin every 3 weeks
11/08 33Rads; 12/08 MUGA 48
2/09 MRI spine and bone scan, old mets to spine, Chest x-ray, blood work, IV NED,regular CPAP use,Zometa x6, first -flue like symptoms 2 days;Herceptin x3; stage 2 lymphoedema..sleeve and glove
4/09 Brain MRI - CLEAR; MUGA 54
7/09 chest ultrasound,
10/09 PET, brain and spin MRI NED Herceptin only. MUGA 59!!!
1/11 Hip replacement 7/11 Hip 2 replacement
4/12 4 years!! Herceptin
6/12 start reconstruction finish in 12/12
2/14 Herception - 6 years!!!
1 Corinthians 10:13 "No temptation has seized you except what is common to man. And God is faithful; he will not let you be tempted beyond what you can bear. But when you are tempted, he will also provide a way out so that you
can stand up under it."
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