KI-67 & Oncotype Tests

Lin · 01-23-2008, 08:54 AM

How long does it normally take to get results back from
KI-67 & ONCOTYPE DX tests AND are the test run against
the tissue given to the pathologist at the time of surgery?

God Bless & praying for a cure.
Lin (Pensacola, FL)

BonnieR · 01-23-2008, 09:05 AM

I beleive the Oncotype literature mentions about 10 days for results. It is performed on tissue obtained during the surgery. There is a special protocol for preparing and mailing it apparently.

Jean · 01-23-2008, 10:20 AM

Lin,
The KI-67 can be found on your pathology reports. So that information should available when you receive your reports.

The Oncotype DX is not performed on a fresh tissue sample, it done on
a parifin slide. Which means, the hospital that is holding your tumor samples needs to be notified and they send the paraifn slide out to
the lab who is performing the Oncotype test. If KI-67 levels are high
don't bother with Oncotype test, as the KI-67 levles will tell you the
same thing. Most Her2 positive do come back high on the Oncotype
DX test.

Regards,
Jean

Lin · 01-23-2008, 10:54 AM

Thanks for the quick reply and info.

For Jean - I've read over the path report and see nothing
that refers to a KI-67 test, how/where would it show on the
report?

God bless and praying for a cure.
Lin (Pensacola, FL)

CPA · 01-23-2008, 11:40 AM

Sometimes listed as MKI67 on path report

Jean · 01-23-2008, 01:22 PM

Lin,
If you can call the lab that did the report and ask them where they have noted this on the report.

Jean

Chelee · 01-23-2008, 02:20 PM

Lin, I have never found what my KI-67 is either? They mention high mitotic activity which goes into the "Richardson scale" which was 9 of 9. I've always wondered if this Richardson scale is like the KI-67? Does your path report mention a Richardson scale? It seems everyone has a KI-67 except a few of us? Some labs must do it differently?

Chelee

Brenda_D · 01-23-2008, 02:32 PM

I believe the mitotic rate is comparative to the KI67.

My biopsy said very high mitotic rate suspected, and indeed, my KI67 was 70% on the surgical path report.

Chelee · 01-23-2008, 03:14 PM

I just took Jean's advice and called the lab that did my path report to ask about my KI-67? I told her I can't find the KI-67 any where on my path report. She took my name & looked me up & said she can't discuss to much with me on the phone since I'm not a physican...but she said she see's my Her2 & FISH was ran there. But she said they did not run a KI-67 on me. She said that is a seperate test.

(I'm not sure what to think of that?) I asked her if the Richardson scale they used on my report was like the KI-67? She said she didn't believe so but all she can say is the KI-67 was NOT ran on me. Humm? I see my onc this Friday & I think I will mention it to her.

Chelee

Alice · 01-23-2008, 09:45 PM

Hi there,
All these tests can be so confusing. I always wanted to know my onco type test score and was told that if you are er- it was not done. it was only a score for those that were er+. Now I was reading a prior reply that stated that the Ki-67 was a similar score? I am just curious having a Ki-67 of 90%, what could that mean in terms of the onco type test? I have never heard of anyone having a 90% or even close. As far as the Richardson Bloome test I am an 8 out of 9. I think the Ki-67 has to do with the amount of proliferation of cells and the Richardson Bloom test is not related to the onco type testing. Any additional info is apreciated. By the way, today is my 2 year out of treatment aniversary!!!!!!!!!!!!!!!!!!!!!
Alice

BonnieR · 01-23-2008, 10:10 PM

Alice, my KI-67 was 90....

Hopeful · 01-24-2008, 07:38 AM

Here is a link to a thread from last June with a lot of info on Ki-67:

http://her2support.org/vbulletin/sho...eferrerid=1173

Hopeful

Jean · 01-24-2008, 09:28 AM

Hopeful,
thank you for posting the link.
I certainly wish when I was first dx. that my dr. had bothered to mentioned my KI 67 level. I have always found it interesting that
three top dr. in NY never ever mentioned it....just the size of my
tumor (I certainly hope that by my case they have stopped doing that)
well, at least I know one of them has. But to move forward. When I went to Dr. Slamon he discussed the KI 67 level with me and said the
following "the dr. in NY missed the boat, since my KI 67 level was
high and chemo/herceptin should have been advised and the size of my tumor was not to be the focus" - my point being the following:

I think it is a shame that "ALL" dr. who are treating patients do not know what the value of these tests mean to their patients. It can make a major difference!

One of the reasons I love this board and the women and men on it!
We share our inforamtion, experiences, and hopefully our NED !

Regards,
Jean

Hopeful · 01-24-2008, 09:49 AM

Jean,

I agree that we need to look at all the information we get from pathology, gene testing, etc., and try to get an overall picture of each individual case to tailor treatment, rather than just focus on one piece of data. My Ki-67 was 11, which, at the lab that did the testing on my tumor, is "borderline" for being positive (they consider anything up to 10 to be "negative"). It was listed in the "good" prognostic column on my path report. My problem for a long time was that no one would explain to me 1)WHAT Ki-67 was and 2) the significance of the score. (Example: Me, talking to my surgeon: "What is this Ki-67 on my path report?" Surgeon: "That's your Ki-67 score.") I had to do research on my own, and found several papers. One paper stated they thought that a minimal score of 30 was needed to determine the efficacy of chemotherapy. My (relatively) low score was a factor in my decision to forego chemo, AND to do Herceptin, as I read another paper where (relatively) lower Ki-67 scores showed a strong response to Herceptin. IMO, the Ki-67 score is a (pardon the pun) "key" piece of information that should be discussed with the patient in determining treatment.

Hopeful

Lani · 01-24-2008, 09:49 AM

but for those of you who are premenopausal it may be important to note that
it varies with the phase of the menstrual cycle (thus the phase you may have been in when your surgery occurred may have caused it to be higher or lower than it might otherwise have been on a different day)

Hope this helps

Jean · 01-24-2008, 10:19 AM

Hopeful,
Isn't that a true shame, I will never accept these situations with dr.'s
Here right on the report are guidelines for treatment, in your case best choice
for you was not to do chemo. Thank goodness you followed up!
Also in noting Lani's post on cycle schedule during testing, yikes
how many dr. know about that, another log to throw on the fire.

Love your sense of humor - it was right on the the nail (pun)...you are one smart
"Cookie"

Hugs,
jean