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09-11-2007, 10:04 AM
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#1
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Senior Member
Join Date: Jul 2007
Location: Northern California
Posts: 764
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Is this True?
I met with my surgeon yesterday. During our visit she mentioned that her2+ cancer tends to prefer solid organs such as liver and lungs as oppossed to bones. Is that true?
__________________
DX 02/01/07
2.5 cm, Er/Pr-, Her2+++
18/20 Nodes
03/07 CT & Bone scan - Clear
AC x 4, Taxol x 4, Added Herceptin
Radiation until 09/07
Herceptin every 3 weeks until 06/08
01/10/08 local recurrence -IBC
01/28/08 CT & Brain MRI - clear
02/08 - Navelbine & Herceptin
05/08 -MRM
05/08 - Gemzar & Herceptin - didn't work
09/08 - Hyperthermia rads
03/09 - Tykerb/Xeloda
05/10 - Tram flap to fix wound
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09-11-2007, 11:47 AM
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#2
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Senior Member
Join Date: Sep 2005
Location: Stockton, NJ
Posts: 4,179
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Yes this is true. Lungs are its first love.
__________________
Kind regards
Becky
Found lump via BSE
Diagnosed 8/04 at age 45
1.9cm tumor, ER+PR-, Her2 3+(rt side)
2 micromets to sentinel node
Stage 2A
left 3mm DCIS - low grade ER+PR+Her2 neg
lumpectomies 9/7/04
4DD AC followed by 4 DD taxol
Used Leukine instead of Neulasta
35 rads on right side only
4/05 started Tamoxifen
Started Herceptin 4 months after last Taxol due to
trial results and 2005 ASCO meeting & recommendations
Oophorectomy 8/05
Started Arimidex 9/05
Finished Herceptin (16 months) 9/06
Arimidex Only
Prolia every 6 months for osteopenia
NED 18 years!
Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"
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09-11-2007, 02:26 PM
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#3
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Senior Member
Join Date: Jan 2007
Posts: 368
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Becky, can you point me to where you got that info?
I've not read that her2+ has a "preference" in sites to metastasize to.
Thanks.
__________________
12/12/06- IDC Stage III, 4x A/C, 35 rads, Herceptin 1 year
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09-11-2007, 05:14 PM
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#4
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Senior Member
Join Date: Mar 2007
Location: Greendale, WI
just outside Milwaukee
Posts: 211
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Becky,
Thanks for info, I did not realize that HER2 made a difference as to first choice for mets. I thought all BC had a tendency toward bones first. KS
__________________
04/05 Onset 49, DCIS, solid, Hist 2/3, Nucl 2/3, 7cm R Brst
04/05 E & P + HER2+++
05/05 Mediport
05/05 Cytoxan & Adriamycin every 3wk x4
08/05 Taxol every 2wk x 4, Herceptin every wk x1yr
10/05 Bilat Mast - my Choice
10/05 3/19 lymph nodes Pos, Stage IIIa
11/05 Rad x 37 Rx, R Brst & Axcilla
02/06 Herceptin stopped (L vent HF 40)
03/06 Started & Stoped Arimidex after 2 mos.-QOL side effects
05/06 Started Tamoxafin
06/06 Bilat Free Flap Reconstruction
12/06 Cardiomyopathy reversed-HF normal
01/07 Bilat Saline Implants
07/07 CA 27-29 steadily rising from 28 in 12/06 to 46 in 7/07
07/07 PET Scan NED, but inflamation at prev surg site.
09/07 Started Femara
10/07 CA 27-29 down to 39
06/08 CA 27-29 down to 32
09/08 Lg joint pain & QOL side effects from Femara, will live w/ to keep CA markers within normal range.
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09-11-2007, 06:15 PM
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#5
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Senior Member
Join Date: Sep 2005
Location: Stockton, NJ
Posts: 4,179
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The information is on this site somewhere. StephN posted it after she returned from going to San Antonio with the group in Dec 2005 or 2004. There was a poster on it. For Her2+ BC, the first site for mets is the lung 21% of the time.
Bones are the first site for highly ER+/PR+ bc and are third on the list. The reason the group advocates brain MRI is that for Her2+, the first site of mets 10% of the time is the brain. The liver is #2. Anyway, it is a StephN post with a link - older post. I am going to Detroit tomorrow for work but when I return, I will try to really look for that post for you.
__________________
Kind regards
Becky
Found lump via BSE
Diagnosed 8/04 at age 45
1.9cm tumor, ER+PR-, Her2 3+(rt side)
2 micromets to sentinel node
Stage 2A
left 3mm DCIS - low grade ER+PR+Her2 neg
lumpectomies 9/7/04
4DD AC followed by 4 DD taxol
Used Leukine instead of Neulasta
35 rads on right side only
4/05 started Tamoxifen
Started Herceptin 4 months after last Taxol due to
trial results and 2005 ASCO meeting & recommendations
Oophorectomy 8/05
Started Arimidex 9/05
Finished Herceptin (16 months) 9/06
Arimidex Only
Prolia every 6 months for osteopenia
NED 18 years!
Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"
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09-11-2007, 11:03 PM
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#6
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Senior Member
Join Date: Oct 2005
Location: southern california
Posts: 287
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I could not find the post from Stephn that relates to this issue. If someone could bring it back up I would be interested in reading it.
Thanks, Alice
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09-12-2007, 05:09 AM
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#7
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Senior Member
Join Date: Jan 2007
Posts: 368
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I searched but didn't find it either. I don't know what search keywords that I need to use, other than "mets" and it brings up too many hits.
__________________
12/12/06- IDC Stage III, 4x A/C, 35 rads, Herceptin 1 year
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