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10-16-2006, 04:58 PM
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#1
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Member
Join Date: Aug 2006
Location: Toronto, Ontario
Posts: 21
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Paclitaxel and Her2-neu
Hello Everyone,
Since I have always gotten a straight and informed answer from this site I thought I would ask the following:
I was reading an abstract of an article (Diindolylmethane (DIM) and Paclitaxel Act Synergistically to Promot apoptosis in HER2/Neu Human Breast Cancer Cells, Jan 2006, Journal of Surgery) and came across a reference to the resistance of HER2-neu tumours to chemotherapy. As an aside, the article noted that HER2-neu overexpression confers resistance to paclitaxel. Unfortunately I could not access the full text of the article. Has anyone heard of any studies looking at the resistance of HER2-neu tumours to paclitaxel or the other taxanes?
Keep well,
Carina
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Carina
Toronto, Canada
DX: 12Dec05, Stage IIIa, invasive ductal carcinoma, extra-nodal extension, ER/PR+, HER-2neu 3+, FISH: 7.8
Chemo: AC + T completed 8Sept06, and Herceptin started started 7Jul06 (Herceptin temp. stopped due to allergy)
Hormonal Treatment: 9Oct06 (Arimadex)
Radiation: To start 10Oct06 (5 weeks)
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10-16-2006, 07:14 PM
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#3
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Senior Member
Join Date: Aug 2006
Location: Sheboygan, WI
Posts: 2,582
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Am I understanding the article correctly? Taxol and herceptin are a good thing. Taxol with herceptin is a great combination?
Hopes so cause that's what I was on. :-)
Mary Jo
__________________
"Be still and know that I am God." Psalm 46:10
Dx. 6/24/05 age 45 Right Breast IDC ER/PR. Neg., - Her2+++ RB Mast. - 7/28/05 - 4 cm. tumor Margins clear - 1 microscopic cell 1 sent. node No Vasucular Invasion 4 DD A/C - 4 DD Taxol & Herceptin 1 full year of Herceptin received every 3 weeks 28 rads prophylactic Mast. 3/2/06
17 Years NED
<>< Romans 8:28
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10-16-2006, 08:04 PM
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#4
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Senior Member
Join Date: Dec 2005
Location: Alexandria, VA
Posts: 1,055
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Only read page 1, but I think the article is saying without Herceptin, Her2+ cancer tends to be resistant to AC and Taxol. With Herceptin, things look much better. BB
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10-16-2006, 09:50 PM
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#5
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Senior Member
Join Date: Sep 2005
Location: Central Coast, CA
Posts: 3,207
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Carina,
What the article says is that Her2 overexpression (that is to say, Her2+++) confers resistance to Paclitaxel. Adding an inhibitor such as Herceptin counters this effect (is a good thing) and increases the effectiveness of the paclitaxel.
So, Herceptin + a taxane is synergistic and is a good thing.
__________________
Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial
5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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10-18-2006, 08:40 AM
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#6
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Member
Join Date: Aug 2006
Location: Toronto, Ontario
Posts: 21
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Thanks for all of your helpful comments and the link to the article. One of the reasons why I was concerned is because I only received Herceptin with Taxol for 2 of my 4 treatments. Due to my allergy, the Herceptin was discontinued and I received Taxol alone for the next two. I have heard that Herceptin can be in your system for up to 6 months, so I am hoping that there was enough still in me to continue to have an effect on the efficacy of the Taxol.
Hoping to be back on Herceptin by November. Currently my oncologist and allergist are working with an oncologist at Harvard to develop a protocol to get me back on Herceptin. Keeping my fingers crossed.
Take care,
Carina
__________________
Carina
Toronto, Canada
DX: 12Dec05, Stage IIIa, invasive ductal carcinoma, extra-nodal extension, ER/PR+, HER-2neu 3+, FISH: 7.8
Chemo: AC + T completed 8Sept06, and Herceptin started started 7Jul06 (Herceptin temp. stopped due to allergy)
Hormonal Treatment: 9Oct06 (Arimadex)
Radiation: To start 10Oct06 (5 weeks)
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