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02-19-2009, 10:04 PM
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#1
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Senior Member
Join Date: Mar 2006
Posts: 4,778
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metformin (common anti diabetes drug)inhibits breast cancer cell growth, colony form-
ation, and induces cell cycle arrest (so they can't multiply)
I have previously posted that metformin decreases her2 protein levels by 85%(put metformin and Lani into the Search on the yellow line above if you want to find that thread)
All work done in cancer cell lines, not in intact people so far:
Cell Cycle. 2009 Mar 26;8(6). [Epub ahead of print]Links
Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro.
Alimova IN, Liu B, Fan Z, Edgerton SM, Dillon T, Lind SE, Thor AD.
Department of Pathology, University of Colorado Denver School of Medicine, Aurora, Colorado USA; Department of Carcinogenesis and Oncogerontology, Prof. N.N. Petrov Research Institute of Oncology, St. Petersburg, Russia.
The anti-diabetic drug metformin reduces human cancer incidence and improves the survival of cancer patients, including those with breast cancer. We studied the activity of metformin against diverse molecular subtypes of breast cancer cell lines in vitro. Metformin showed biological activity against all estrogen receptor (ER) positive and negative, erbB2 normal and abnormal breast cancer cell lines tested. It inhibited cellular proliferation, reduced colony formation and caused partial cell cycle arrest at the G(1) checkpoint. Metformin did not induce apoptosis (as measured by DNA fragmentation and PARP cleavage) in luminal A, B or erbB2 subtype breast cancer cell lines. At the molecular level, metformin treatment was associated with a reduction of cyclin D1 and E2F1 expression with no changes in p27(kip1) or p21(waf1). It inhibited mitogen activated protein kinase (MAPK) and Akt activity, as well as the mammalian target of rapamycin (mTOR) in both ER positive and negative, erbB2-overexpressing and erbB2-normal expressing breast cancer cells. In erbB2-overexpressing breast cancer cell lines, metformin reduced erbB2 expression at higher concentrations, and at lower concentrations within the therapeutic range, it inhibited erbB2 tyrosine kinase activity evidenced by a reduction of phosphorylated erbB2 (P-erbB2) at both auto- and Src- phosphorylation sites. These data suggest that metformin may have potential therapeutic utility against ER positive and negative, erbB2-overexpressing and erbB2-normal expressing breast cancer cells.
PMID: 19221498
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02-20-2009, 05:55 AM
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#2
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Senior Member
Join Date: Feb 2008
Location: Georgia
Posts: 1,486
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Lani,
Do you think they will do more studies with this drug? Very interesting article.
Amelia
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02-20-2009, 07:35 AM
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#3
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Senior Member
Join Date: Jun 2006
Location: san luis obispo, ca
Posts: 1,150
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Lani, Very Intriguing article. How does eone go about knowing if they are erb2. I have looked over all of my path reports and none of them show that. I am surrently taking a drug called Naltrexone (low dose) that also causes cancer cell aptosis. It is given to people who are coming off of opiate drugs, as well as, many other things. I am going to research your drug further. Thank you so much for posting it. I always love to hear what you have found. Love, Vickie
__________________
Love and Hugs, Vickie
Life's not about waiting for the storm to pass,
It's about learning to dance in the rain.
Feb 04 IBC IIIC/IV er-/pr- her2+++
3/04 TCH X4
7/ 04 MRM 9/04 Taxol/herceptin wkly 1 yr 33X rads
11/04 skin mets 33x rads,10/05 Avast/Herc. 11 mos.
8/ 06 PET mets lymphs, neck
9/ 06 Navelbine/herceptin
11/ 06 PET NED
2/ 07 skin mets, 4/07 Xeloda, 5/07 add Tykerb
2/ 08 Tykerb failed. Doxil /Herceptin 6 months
8/08 PET skin mets, 8/08 Abraxane/Avastin
11/ 08 PET prog., skin mets
1/09 PET/CT progress, 1/09 Ixempra, 2/09 add Xeloda and low dose Naltrexone
2/09 off Ixempra/Xeloda
3/09 navelbine/herc/cytoxin 4/09 PET shows regress.7/09 start Topotecan. Failed.
8/09 extensive mets rgt brst, back and torso. starting Pazopanib clinical trial.
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02-20-2009, 10:42 AM
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#4
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Senior Member
Join Date: Mar 2006
Posts: 4,778
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reply
yes, the article suggested a trial
erbb2 is the same as her2
Since metformin is a drug used to treat a disease (diabetes) and is by prescription only (which means it has side effects and shouldn't be used by those without that disease unless for another disease for which it is effective and for which it gives more benefit than the risk of adverse side effects) this is something to go over with your doctor.
If you are very overweight and have been borderline diabetic and your doctor read this and discussed the possible side effects with you... it is still not clear that what happens in a petri dish happens in people. Sometimes the effect of a drug is nonexistant or THE OPPOSITE in whole humans and sometimes the effect is opposite depending what dose is taken (how do we know the correct dose for the effect and if that dose is safe?)
Trial may take a while as no new blockbuster drug still under patient is involved.
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02-20-2009, 10:56 AM
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#5
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Senior Member
Join Date: Oct 2006
Location: I live in Christmas, MI - located on the shores of Lake Superior.
Posts: 606
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As always..thanks for the info.
__________________
Barb
10/03 Radical Mastectomy 3 cm tumor - 1/17 Nodes Stage II B, Her 2 +++ ER-/PR- 11/03 4 AC 4 Taxol 12/05 Stage IV - Lung met , Bone mets - Carbo, Taxotere, Herceptin 9/06 - 2 cm brain tumor 10/06 - Tumor removal surgery - Herceptin Halted 12/06 gamma knife tumor base.1/07 Navelbine/Herceptin 4/07 Rads to R femur 5/07 Stereotactic - new 2 cm brain tumor 4/07 Start Xeloda 5/07 Tykerb added 7/07 Brain MRI clean 10/07 .055 cm brain met found. 12/07 Stereotactic -1 cm brain tumor Start Tykerb 11/07 Abraxane/Herceptin 5/08 Cisplatin, Gemcitabine/Herceptin 6/08 Stereotactic to 1cm 9/08 Stereotactic repeat (growth). 11/08 Pet Scan Good but new tiny met on L lung/dead Brain surgery (no cancer cells found/scar tissue) 1/09 Chemo restarted 2/09 Pet Scan Bad - R larger very active/active L active lymph nodes both sides of chest MRI- mets slight increase 2/09 Start Doxil/Tykerb Treatment
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02-20-2009, 11:40 AM
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#6
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Senior Member
Join Date: Sep 2005
Location: Alaska
Posts: 2,018
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connections
Thanks for all the interesting discussions, Lani. This one is really intriguing.
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