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Old 06-02-2010, 11:15 PM   #1
Sherryg683
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CNN Report Promising Cure Vaccine

Got a call from a friend today, she saw this report on CNN about what they are saying is a promising cure for breast cancer, it's a vaccine...Anyone heard any more on it. One report said they could start trials of it on humans within the next year....here's link...sherryghttp://www.cnn.com/2010/HEALTH/05/31/breast.cancer.vaccine/index.html
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13+ positive lymph nodes
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Old 06-02-2010, 11:15 PM   #2
Sherryg683
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Re: CNN Report Promising Cure Vaccine

http://www.cnn.com/2010/HEALTH/05/31...ine/index.html

sorry link got scrambled in with my signature
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Diagnosed: December , 2005 at age 44
13+ positive lymph nodes
Stage IV , Her2+, 2 small mets to lungsChemo Started: Jan, 2006
4 months Taxotere, Xeloda, Hercepin
NED since April 2006!!
36 Rads to follow with weekly Herceptin indefinately
8 years NED now
Scans every year

Life is not about avoiding the thunderstorms, it's about learning to dance in the rain!
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Old 06-03-2010, 12:21 AM   #3
Jean
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Re: CNN Report Promising Cure Vaccine

Yes Sherry I did watch it on the news and it was in our newspaper.

They are calling it a BREAKTHROUGH headline reads:

BREAKTHROUGH may end breast tumors.
The test study on mice have been overwhelmingly favorable results. Dr. Vincent Tuohy who led the resarch at the Cleveland Clinic in Ohio said there was evidence in the initial tests that the vaccine could prevent cancers from forming and stop the growth of existing tumors.

If it works in humans the way it works in mice, this will be monumental. They believe this vaccine will someday be used to prevent breast cancer. Researchers injected the test vaccine into six mice that were specifically bred to be prone to breast cancer. None developed any signs of tumors. Six other mice bred in the same way were
injected with a placebo vaccine and all developed tumors.

The drug makes the immune system attack a particular protein found in most breast cancer cells and in the mammary tissue of breast feeding women.

If clinical tests of the vaccine on humans are successful, women over 40 could be vaccinated.

This is an early stage study, and large scale clinical trials will begin to find out if this vaccine would be safe and effective in humans.

As I listened to the news I had tears streaming down my face, thinking of all our losses this year and hopefully the bright future that awaits us. (of course there will be years of study).

Each day we get closer.
Jean
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Last edited by Jean; 06-03-2010 at 12:24 AM..
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Old 06-03-2010, 05:18 AM   #4
Lori R
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Re: CNN Report Promising Cure Vaccine

Sherry and Jean,
Thank you for posting!! This is great news and I sure hope they figure out the details quickly. I am encouraged by the study coming out of a respected institution such as the Cleveland Clinic. Hoping that it enables them to acquire resources to move this forward.

As always....your insights provide me with a hope boost for the day.
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2007
Oct - Diagnosed - Stage IV
5 c.m. IDC - Left Side er/pr- Her2+++
Node + 2/14 - Single Liver Met
Double Mastectomy
Nov - Begin T+H
2008
Feb-Complete 6 cycles- T&H- NED
March - Continue - Herceptin Only
April - Rads for 6 weeks
2009
Continue Herceptin - Continue NED
April - Recurrance- 3 cm. Liver Met
May - Cryosurgery
June - November - Abraxane + Herceptin
Aug - PET/CT - CTC = 0 Back to NED
2010
January - Continue NED
July - Recurrance - 3 cm Liver Met CTC=1
August - Cryosurgery #2
August - November Navelbine
November - Back to NED - End Navelbine
2011
Feb - Recur - 4 cm Liver Met - Same Left Lobe
March Surgery it is -Couldn't get a clean margin
July - Confirmed continued liver involvement
August - Begin Herceptin + Tykerb
October - Mixed results from H+T
Add Abraxane + H + T - Nov - April
2012
January PET Scan - It's working!!
April - Back to NED
July - Recurrance
August - Begin TDM-1 Trial (Taxol + TDM-1)
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Old 06-03-2010, 08:45 AM   #5
Sherryg683
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Re: CNN Report Promising Cure Vaccine

It said that they will probably start trials in humans with a year. I am so wondering what they will require to be admitted into the trial...i would love to get on this vaccine.....sherry
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Diagnosed: December , 2005 at age 44
13+ positive lymph nodes
Stage IV , Her2+, 2 small mets to lungsChemo Started: Jan, 2006
4 months Taxotere, Xeloda, Hercepin
NED since April 2006!!
36 Rads to follow with weekly Herceptin indefinately
8 years NED now
Scans every year

Life is not about avoiding the thunderstorms, it's about learning to dance in the rain!
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Old 06-03-2010, 10:19 AM   #6
bejuce
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Re: CNN Report Promising Cure Vaccine

Same here... I'm waiting for a vaccine trial to be open at Stanford in the Fall, but this one in Cleveland is looking very, very promising.
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Diagnosed on 02/18/09 at 38 with a huge 12x10 cm tumor, after a 6 month delay. Told I was too young and had no risk factors. Found swollen node during breastfeeding.
March-August 09: neo-adjuvant chemo, part of a trial at Stanford (4 DD A/C, 4 Taxotere with daily Tykerb), loading dose of Herceptin
08/12/09 - bye bye boobies (bilateral mastectomy)
08/24/09 - path report shows 100 % success in breast tissue (no cancer there, yay!), 98 % success in lymphatic invasion, and even though 11/13 nodes were still positive, > 95 % of the tumor in them was killed. Hoping for the best!
September-October 09: rads with daily Xeloda
02/25/10 - Cholecystectomy
05/27/10 - Bone scan clear
06/14/10 - CT scan clear, ovarian cyst found
07/27/10 - Done with Herceptin!
02/15/11 - MVA-BN HER-2 vaccine trial
03/15/11 - First CA 15-3: 12.7 and normal, yay!
10/01/11 - Bone scan and CT scan clear, fatty liver found
now on Tamoxifen and Aspirin


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Old 06-03-2010, 11:47 AM   #7
Ellie F
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Re: CNN Report Promising Cure Vaccine

Hi Marcia
Do you know what type of vaccine trial they will be opening at Stanford?

Thanks Ellie
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Old 06-03-2010, 03:56 PM   #8
Faith in Him
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Re: CNN Report Promising Cure Vaccine

I hope this is the answer for many of us.
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2.5 cm, Er/Pr-, Her2+++
18/20 Nodes
03/07 CT & Bone scan - Clear
AC x 4, Taxol x 4, Added Herceptin
Radiation until 09/07
Herceptin every 3 weeks until 06/08
01/10/08 local recurrence -IBC
01/28/08 CT & Brain MRI - clear
02/08 - Navelbine & Herceptin
05/08 -MRM
05/08 - Gemzar & Herceptin - didn't work
09/08 - Hyperthermia rads
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Old 06-03-2010, 04:04 PM   #9
bejuce
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Re: CNN Report Promising Cure Vaccine

Hi Ellie,

Not sure yet, just know that it'll be open soon and it may be a possibility for me according to my oncologist. I'll keep you all posted once I find out more about it.

Marcia
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ER+ (30%)/PR-/HER-2+, stage 3

Diagnosed on 02/18/09 at 38 with a huge 12x10 cm tumor, after a 6 month delay. Told I was too young and had no risk factors. Found swollen node during breastfeeding.
March-August 09: neo-adjuvant chemo, part of a trial at Stanford (4 DD A/C, 4 Taxotere with daily Tykerb), loading dose of Herceptin
08/12/09 - bye bye boobies (bilateral mastectomy)
08/24/09 - path report shows 100 % success in breast tissue (no cancer there, yay!), 98 % success in lymphatic invasion, and even though 11/13 nodes were still positive, > 95 % of the tumor in them was killed. Hoping for the best!
September-October 09: rads with daily Xeloda
02/25/10 - Cholecystectomy
05/27/10 - Bone scan clear
06/14/10 - CT scan clear, ovarian cyst found
07/27/10 - Done with Herceptin!
02/15/11 - MVA-BN HER-2 vaccine trial
03/15/11 - First CA 15-3: 12.7 and normal, yay!
10/01/11 - Bone scan and CT scan clear, fatty liver found
now on Tamoxifen and Aspirin


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Old 06-03-2010, 05:10 PM   #10
Patb
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Re: CNN Report Promising Cure Vaccine

This is wonderful news but they came on with
this big announcement on our news and said
cure for breast cancer coming up and went on about
it. If people need it now that was very misleading.
It could be years to be available. That it is good
news is true, but not yet.
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Diagnosed June, 06, Stage I, Grade3, ER+PR- Her2positive, No Nodes. A/C X 4. Radiation 33 with boost, Herceptin every two weeks until Nov.
07, Arimedex for 5 years. Mugas and Echo and chest xRay. Bone scan of whole Body, and Back of Brain and spine MRI.
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Old 06-03-2010, 05:30 PM   #11
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Re: CNN Report Promising Cure Vaccine

Uh oh, here comes the contrarian downer...

Absolutely, this is reason to be hopeful but healthy skepticism should always rule the day when considering mouse-model research. Researchers are optimistic, but they also always warn that it's a big leap from results in animals to similar results in humans and there is no guarantee the treatment will make it to human trials... and according to the article, there is no funding for human trials at this point, though it has been applied for. I have read about 8 different news stories about it and not one of them has said that the FDA has approved human trials yet. If it does translate to wonderful results in humans, experts speculate it will take at least 10 years to get the vaccine to mainstream use.

All that said, I hope beyond hope they are on to something and that they HURRY!
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NOV 2012 - 9 yr anniversary
JULY 2012 - 7 yr anniversary stage IV (of 50...)

Nov'03~ dX stage 2B
Dec'03~
Rt side mastectomy, Her2+, ER/PR+, 10 nodes out, one node positive
Jan'04~
Taxotere/Adria/Cytoxan x 6, NED, no Rads, Tamox. 1 year, Arimadex 3 mo., NED 14 mo.
Sept'05~
micro mets lungs/chest nodes/underarm node, Switched to Aromasin, T/C/H x 7, NED 6 months - Herceptin only
Aug'06~
micro mets chest nodes, & bone spot @ C3 neck, Added Taxol to Herceptin
Feb'07~ Genetic testing, BRCA 1&2 neg

Apr'07~
MRI - two 9mm brain mets & 5 punctates, new left chest met, & small increase of bone spot C3 neck, Stopped Aromasin
May'07~
Started Tykerb/Xeloda, no WBR for now
June'07~
MRI - stable brain mets, no new mets, 9mm spots less enhanced, CA15.3 down 45.5 to 9.3 in 10 wks, Ty/Xel working magic!
Aug'07~
MRI - brain mets shrunk half, NO NEW BRAIN METS!!, TMs stable @ 9.2
Oct'07~
PET/CT & MRI show NED
Apr'08~
scans still show NED in the head, small bone spot on right iliac crest (rear pelvic bone)
Sept'08~
MRI shows activity in brain mets, completed 5 fractions/5 consecutive days of IMRT to zap the pesky buggers
Oct'08~
dropped Xeloda, switched to tri-weekly Herceptin in combo with Tykerb, extend to tri-monthly Zometa infusion
Dec'08~
Brain MRI- 4 spots reduced to punctate size, large spot shrunk by 3mm, CT of torso clear/pelvis spot stable
June'09~
new 3-4mm left cerrebellar spot zapped with IMRT targeted rads
Sept'09~
new 6mm & 1 cm spots in pituitary/optic chiasm area. Rx= 25 days of 3D conformal fractionated targeted IMRT to the tumors.
Oct'09~
25 days of low dose 3D conformal fractionated targeted IMRT to the bone mets spot on rt. iliac crest that have been watching for 2 years. Added daily Aromasin back into treatment regimen.
Apr'10~ Brain MRI clear! But, see new small spot on adrenal gland. Change from Aromasin back to Tamoxifen.
June'10~ Tumor markers (CA15.3) dropped from 37 to 23 after one month on Tamoxifen. Continue to monitor adrenal gland spot. Remain on Tykerb/Herceptin/Tamoxifen.
Nov'10~ Radiate positive mediastinal node that was pressing on recurrent laryngeal nerve, causing paralyzed larynx and a funny voice.
Jan'11~ MRI shows possible activity or perhaps just scar tissue/necrotic increase on 3 previously treated brain spots and a pituitary spot. 5 days of IMRT on 4 spots.
Feb'11~ Enrolled in T-DM1 EAP in Denver, first treatment March 25, 2011.
Mar'11~ Finally started T-DM1 EAP in Denver at Rocky Mountain Cancer Center/Rose on Mar. 25... hallelujah.

"I would rather be anecdotally alive than statistically dead."
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Old 06-03-2010, 05:39 PM   #12
Rich66
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Re: CNN Report Promising Cure Vaccine

Maybe insights from this will inform things already underway.
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Old 06-03-2010, 06:02 PM   #13
1rarebird
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Thumbs up Re: CNN Report Promising Cure Vaccine

If this vaccine pans out to be the long sought "cure" for breast cancer, then the doctors involved will be Nobel prize winners in medicine. I certainly hope to see them in Norway one day accepting the reward ---

bird
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Old 06-03-2010, 06:07 PM   #14
Debbie L.
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Re: CNN Report Promising Cure Vaccine

(I'm surprised that anyone is ever able to post as "unregistered". I've tried repeatedly, thinking it would be faster than logging in - and I can NEVER get those dang anti-spam letters correct. Sheesh.)

So, this report is interesting but is nowhere close to being a breakthrough, or the cure, or anything LIKE that. This report is about SIX MICE. There are legions of studies with incredibly impressive results in mice that did not turn out to work, at all, in humans.

Gary Schwitzer has an excellent website where he critiques news reports of medical advances, and he does a great job of reminding us when the media headlines overstep the reality of what is being reported. If you are interested in medical/cancer news, you owe it to yourself to have a basic understanding of what is important vs. what might, maybe, someday, perhaps -- turn out to be important. Here's what he said about FOX news (and others) reporting on this story:

http://www.healthnewsreview.org/blog...st-cancer.html

If you find that interesting, you could also check out a website referenced by Gary, and look especially at the link to their criteria for "what consumers need in stories" (box on top right): http://www.healthnewsreview.org/

It's good that scientists are asking these important questions and keeping us posted about what they're finding. But it's bad that the media can at times be so irresponsible in how they report these things. For inspiration, check out Gary's recent report of how a breast cancer advocate took a southern California NBC affiliate to task for their poor reporting: Sandra Spivey speaks out

Don't get me wrong. I am actually pretty excited about the potential for a prevention vaccine. But it's FAR from ready for prime time.

If you've made it this far, you are interested. Another excellent opportunity for breast cancer advocates to educate themselves (and with that knowledge, to help others) is offered by NBCC. They now have two versions of their Project LEAD program, to educate interested advocates about the science. The program is free (thanks to grants from Avon) and they offer scholarships to help with travel and lodging, if needed: Project LEAD


(Here's what NBCC says about this vaccine report: MICE)

Debbie Laxague


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Old 06-03-2010, 06:08 PM   #15
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Re: CNN Report Promising Cure Vaccine

The following sentence told me all I needed to know. It is not for the likes of me who already HAVE the disease.

"However, he speculates it will take at least 10 years to get the vaccine to normal, healthy women at risk of developing the cancer."

How they will determine who is "at risk" for developing breast cancer looks like a tough nut to crack. Just being a living human is a broad category!

I must point out that there are numerous other projects being worked on which are meant to spur the immune system against some other targets. My money is on another study in progress that will not take as long as 10 years from now.
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Live in the moment.

MY STORY SO FAR ~~~~
Found suspicious lump 9/2000
Lumpectomy, then node dissection and port placement
Stage IIB, 8 pos nodes of 18, Grade 3, ER & PR -
Adriamycin 12 weekly, taxotere 4 rounds
36 rads - very little burning
3 mos after rads liver full of tumors, Stage IV Jan 2002, one spot on sternum
Weekly Taxol, Navelbine, Herceptin for 27 rounds to NED!
2003 & 2004 no active disease - 3 weekly Herceptin + Zometa
Jan 2005 two mets to brain - Gamma Knife on Jan 18
All clear until treated cerebellum spot showing activity on Jan 2006 brain MRI & brain PET
Brain surgery on Feb 9, 2006 - no cancer, 100% radiation necrosis - tumor was still dying
Continue as NED while on Herceptin & quarterly Zometa
Fall-2006 - off Zometa - watching one small brain spot (scar?)
2007 - spot/scar in brain stable - finished anticoagulation therapy for clot along my port-a-catheter - 3 angioplasties to unblock vena cava
2008 - Brain and body still NED! Port removed and scans in Dec.
Dec 2008 - stop Herceptin - Vaccine Trial at U of W begun in Oct. of 2011
STILL NED everywhere in Feb 2014 - on wing & prayer
7/14 - Started twice yearly Zometa for my bones
Jan. 2015 checkup still shows NED
2015 Neuropathy in feet - otherwise all OK - still NED.
Same news for 2016 and all of 2017.
Nov of 2017 - had small skin cancer removed from my face. Will have Zometa end of Jan. 2018.
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Old 06-03-2010, 06:10 PM   #16
Laurel
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Re: CNN Report Promising Cure Vaccine

Hey, Brenda, what I say to your post is: "crap on a crapstick!" That's right, you heard me! CRAP ON A CRAPSTICK!

You know, since you have posted that at times here on Her-2 I have co-opted it. Boy, does it throw the locals here in Pa! I just tell them it's a Tx expression! BTW, is it?

Well, gang, it sure would be nice if this does work in humans and fast tracks for all of us and our daughters (and I guess sons, too, Rarebird).
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Dx'd w/multifocal DCIS/IDS 3/08
7mm invasive component
Partial mast. 5/08
Stage 1b, ER 80%, PR 90%, HER-2 6.9 on FISH
0/5 nodes
4 AC, 4 TH finished 9/08
Herceptin every 3 weeks. Finished 7/09
Tamoxifen 10/08. Switched to Femara 8/09
Bilat SPM w/reconstruction 10/08
Clinical Trial w/Clondronate 12/08
Stopped Clondronate--too hard on my gizzard!
Switched back to Tamoxifen due to tendon pain from Femara

15 Years NED
I think I just might hang around awhile....

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Old 06-03-2010, 08:54 PM   #17
Jean
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Re: CNN Report Promising Cure Vaccine

I realize it is only 6 mice...and that it will take at least 10 years of additional study. But we have to start somewhere. Just remember how herceptin started.

I also agree the news revs it up -
I am still praying that the cup is half full and who knows what is around the corner.

That's my story and I am sticken to it!

Love to all,
jean
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Stage 1, Grade 1, 3/30/05
Lumpectomy 4/15/05 - 6MM IDC
Node Neg. (Sentinel node)
ER+ 90% / PR-, Her2+++ by FISH
Ki-67 40%
Arimidex 5/05
Radiation 32 trt, 5/30/05
Oncotype DX test 4/17/06, 31% high risk
TOPO 11 neg. 4/06
Stopped Arimidex 5/06
TCH 5/06, 6 treatments
Herceptin 5/06 - for 1 yr.
9/06 Completed chemo
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Old 06-04-2010, 10:38 AM   #18
Christine MH-UK
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Re: CNN Report Promising Cure Vaccine

I was also a bit disappointed that this is being talked about in the press as something that will prevent all breast cancer in the future when the vaccine will not do anything to prevent breast cancer occurring in young women. Because its target is also present in the breasts of breastfeeding women, the inventor is talking about only giving it to women over 40. Since I was diagnosed in my 30s, I am not impressed.
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Old 06-04-2010, 01:09 PM   #19
MJo
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Re: CNN Report Promising Cure Vaccine

I saw the researcher on the Keith Olbermann show on MSNBC a few nights ago (Olbermann said his mom died of BC). The researcher said what others here have reported -- he doesn't have any funding and it will take 10 years before this reaches the public. My thoughts were "speed it up" and where can I sign up for the shot!
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IDC, Stage I, Grade 2
Oncotype DX Score 32
Her2++ E+P+, Node Neg.
Lumpectomy 11/04/05 Clear Margins
3 Dose dense AC (Couldn't tolerate 4)
4 Dose dense Taxol & Herc. (Tolerated well)
36 weeks Herceptin (Could not complete one year due to decrease in MUGA score)
2 years of Arimidex, then three years of Femara
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Old 06-04-2010, 04:04 PM   #20
Lien
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Re: CNN Report Promising Cure Vaccine

Sounds tempting, doesn't it, to sign up. But we have no idea whatsoever about side effects and long term effects. Yes, if one has mets and is at the end of the chemo rope, one might consider signing up. But so far it has only worked in 6 mice.

It would be wonderful if it worked, though and I do hope they get funding and can start doing more tests. I read it's not just BC they are working on, but other forms of cancer too.

Jacqueline
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