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Old 04-01-2013, 08:17 PM   #1
chrisy
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Re: "More than 20 lesions" - MRI report

Penny,
By definition herceptin alone doesn't work if you have had progression. It needs hep.

I asked the same question before I went on TDM1 - why would this work if herceptin.

My dr gave a much better answer. Because its different! You are not relying on the herceptin to deal with the dancer...you are using it as a targeting mechanism to find the cancer cells and deliver the payload directly to the cell. Keep faith..

Brenda, Sheila and I had a response for that kind of MRI news. It began with W and ended with F.

Hang in here!
Chris
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June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial

5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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Old 04-02-2013, 12:03 AM   #2
michka
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Re: "More than 20 lesions" - MRI report

Penny, I understand you so well. I had the same questions about TDM1. Herceptin never worked for me. I had 2 dozens of tumors all over, including the liver, when I relapsed. As KDR wrote , "thus far" TDM1 is working well for me. It is worth trying. Be angry and go! Hugs. Michka
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08.2006 3 cm IDC Stage 2-3, HER2 3+ ER+90% PR 20%
FEC, Taxol+ Herceptin, Mastectomy, Radiation, Herceptin 1 year followed by Tykerb 1 year,Aromasin /Faslodex

12.2010 Mets to liver,Herceptin+Tykerb
03.2011 Liver resection ER+70% PR-
04.2011 Herceptin+Navelbine+750mg Tykerb
06.2011 Liver ned, Met to sternum. Added Zometa 09.2011 Cyberknife for sternum
11.2011 Pet clear. Stop Navelbine, continuing on Hercpetin+Tykerb+Aromasin
02.2012 Mets to lungs, nodes, liver
04.2012 TDM1, Ned in 07.2012
04.2015 Stop TDM1/Kadcyla, still Ned, liver problems
04.2016 Liver mets. Back on Kadcyla
08.2016 Kadcyla stopped working. mets to liver lungs bones
09.2016 Biopsy to liver. no more HER2, still ER+
09.2016 CMF Afinitor/Aromasin/ Xgeva.Met to eye muscle Cyberknife
01.2017 Gemzar/Carboplatin/ Ibrance/Faslodex then Taxotere
02.2017 30 micro mets to brain breathing getting worse and worse
04.2017 Liquid biopsy/CTC indicates HER2 again. Start Herceptin with Halaven
06.2017 all tumors shrunk 60% . more micro mets to brain (1mm mets) no symptoms
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Old 04-02-2013, 12:37 AM   #3
Jackie07
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Re: "More than 20 lesions" - MRI report

Wondered if that's one of the reasons why the name has been changed to 'Kadcyla' http://www.immunogen.com/pipeline/tr...mab-emtansine/

Looks like Herceptin only plays the role of a 'vehicle' in this one. The 'toxin' (emtansine) is the one that kills the cancer cells.
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Last edited by Jackie07; 04-03-2013 at 08:29 AM..
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