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06-23-2009, 02:36 PM
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#1
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Senior Member
Join Date: Jul 2006
Posts: 869
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tykerb/xeloda...no rash
Has anyone been on this and done well who did not get the rash...I have had a lot of the side effects but just a few blemishes.. Ceesun
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06-24-2009, 12:50 AM
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#2
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Senior Member
Join Date: Jun 2007
Location: RHODE ISLAND
(Ed getting me a latte on 2nd Cancerversary Cruise 2008)
'BELIEVE': To accept as true or real, To have faith in, To presume
ALWAYS BELIEVE
Posts: 2,999
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Ceesun, Ed had a few of the side effects and never the rash nor hand/feet problems. I also add that not having the rash no way proves the efficiency of the combo. Looks to me like you are rocking on forward girl. How are you feeling on these two wonder drugs? Please know that I have been a little preoccupied but you are on the daily prayers I say. Continued success showing cancer just who is boss!!>>Believe51
__________________
9/7/06Husband 50yrs=StageIV IBC/HER2+,BoneMets10/06TaxotereX10,'H'1X wk,Zometa,Tamoxifen4/12/07Last Tax5/18/07Pet=Rapid Cell Activity,No Organ Mets,Lytic Lesions,Degeneration,Some Bone Repair5/07ChemoFail6/01/07Pleural Thoracentisis=Effusions,NoMalignantCells6/19/07+7/2/07DFCI
6/25/07BrainMRI=BrainMets,Many<9mm7/10/07WBR/PelvisRad37.5Gx15&Nutritionist8/19/07T/X9/20/07BrainMRI=2<2mm10/6/07Pet=BoneProgression
10/24/07ChemoFail11/9/07A/Cx10,EndTam12/7/07Faslodex12/10/07Muga7512/13/07BlasticLesions1/7/08BrainMRI=Clear4/1/08Pet=BoneImprovement,
NoProgression,Stable4/7/08BrainPerfect5/16/08Last A/C8/26/08BrainMets=10(<9mm)9/10/08Gamma10/30/08Met=5mm12/19/08Gamma5mets5
12/22/08SpinalMets1/14/09SpinalRads2/17/09BrainMRI=NoNewMets4/20/09BoneScan5/14/09Ixempra6/1/09BrainMRI=NumerousMets6/24/09DFCIw/DrBurstein6/26/09Continue
Ixempra/Faslodex/Zometa~TM now lower7/17/09Stop Ixempra By Choice9/21/09HOSPICE10/16/09Earned His Deserved Wings And Halo=37 Month Fight w/Stage 4 IBC, Her2+++,My Hero!!
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06-30-2009, 11:20 AM
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#3
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Senior Member
Join Date: Dec 2006
Posts: 415
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Hi Ceesun~
Just wanted to share w/you some info my Onc told me about the Tykerb "rash"...
First & foremost, remember toxicity is not indicative of efficacy, so you can't correlate how well the drug is working based on how the SE's present for each person.
And she said that in her experience, the Tykerb "rash" aka acne is typically fairly mild in BC pts. She said that the pics she's seen of mild/moderate/severe "rashes" are likely patients on other Tyrosine Kinase Inhibitors, like Tarceva, with diagnoses other than BC.
I hope this eases your mind a bit & I hope you're continuing to tolerate the new combo well 
Keep the Faith~
Jml |
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06-30-2009, 12:35 PM
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#4
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Senior Member
Join Date: Sep 2005
Location: Central Coast, CA
Posts: 3,207
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Hey Ceesun,
I remember when I was on the Tykerb/Avastin trial, I ratted out the chemo nurses to Dr. Rugo for telling patients that "the rash" meant it was working. (I didn't mean to be ratting them out, I just mentioned it)...well she just about blew a gasket, and told me that although with other TKI's in other cancer there did seem to be a correlation there was "NO DATA" proving a correlation in BC.
Sounds similar to what jml reported above.
We have enough to worry about without stressing over NOT having side effects, eh? Hang in there, my friend.
__________________
Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial
5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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06-30-2009, 01:59 PM
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#5
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Senior Member
Join Date: Jul 2007
Location: Northern California
Posts: 764
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No rash for me either. For me, that was good because I was fighting a cancer rash so I was concerned I would not know what was what.
__________________
DX 02/01/07
2.5 cm, Er/Pr-, Her2+++
18/20 Nodes
03/07 CT & Bone scan - Clear
AC x 4, Taxol x 4, Added Herceptin
Radiation until 09/07
Herceptin every 3 weeks until 06/08
01/10/08 local recurrence -IBC
01/28/08 CT & Brain MRI - clear
02/08 - Navelbine & Herceptin
05/08 -MRM
05/08 - Gemzar & Herceptin - didn't work
09/08 - Hyperthermia rads
03/09 - Tykerb/Xeloda
05/10 - Tram flap to fix wound
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