After chatting with various proponents, the shroom issue might be complicated by things like what soil the shrooms are grown on.
But things like the below give me pause:
Estrogen-like activity of ethanol extract of Ganoderma lucidum
Journal
Journal of Wood Science PublisherSpringer Japan ISSN1435-0211 (Print) 1611-4663 (Online) Issue
Volume 55, Number 1 / February, 2009 CategoryOriginal Article DOI10.1007/s10086-008-0992-2 Pages53-59 Subject Collection
Biomedical and Life Sciences SpringerLink DateThursday, October 23, 2008
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Original Article
Estrogen-like activity of ethanol extract of
Ganoderma lucidum
Kuniyoshi Shimizu1, Ichiko Miyamoto1, Jie Liu1, Fumiko Konishi2, Shoichiro Kumamoto2 and Ryuichiro Kondo1
(1) Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan (2) Chlorella Industry Co. Ltd., Fukuoka 833-0056, Japan
Received: 21 January 2008
Accepted: 9 July 2008
Published online: 22 October 2008
Abstract The ethanol extract from the fruiting body of
Ganoderma lucidum was tested for its estrogen-like activity by using the cell proliferation assay (MCF-7 cells, human breast cancer cells), as well as the estrogen receptor binding assay, and pS2 mRNA expression assay in MCF-7 cells in vitro and uterotrophic assay in vivo. The ethanol
extract of G. lucidum showed significant positive effects on the proliferation of MCF-7 cells. This proliferation effect is related to the estrogenic activity of G. lucidum, because this proliferation activity was inhibited by the addition of the antiestrogenic compound ICI 182,780. The ability to bind to human estrogen receptors (hERs) α and β of the ethanol extract of
G. lucidum was confirmed by using the coactivator-bacterial alkaline phosphatase system. ER-dependent cell responsibilities were investigated by examining the regulation of gene transcription for pS2 in MCF-7 cells. Our results demonstrated that the
pS2 mRNA levels are significantly increased by the ethanol extract of G. lucidum via an estrogen-like manner. Additionally, young rats that received the ethanol extract of G. lucidum (200 mg/kg per day) for 3 days showed a signifi cant increase (growth approximately twofold compared with the control group) in uterine weight after each treatment, which supports the estrogen-like activity of the ethanol extract of G. lucidum in vivo. It was concluded that the ethanol extract of
G. lucidum showed estrogen-like activity, which may be useful in regulating hormone levels to treat related diseases such as osteoporosis if safety is fully guaranteed.
Key words
Ganoderma lucidum - Estrogenic activity - Menopausal syndrome
Ryuichiro Kondo
Email: ryukondo@agr.kyushu-u.ac.jp
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