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Old 03-11-2017, 06:39 AM   #1
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Join Date: Jun 2014
Posts: 162
ORU professor explains his breast cancer research breakthrough that's got him 'freaki

ORU professor / research / mushrooms


Could cancer-eating mushrooms offer a cure to some forms of breast cancer that resist all other forms of treatment?
A researcher and professor at Oral Roberts University is exploring that possibility and is encouraged by what he sees so far.
William Ranahan, head of ORU’s Ranahan Cancer Lab, recently talked about his research at The Assembly, a large church in Broken Arrow.
Ranahan is aware that most people would consider it improbable that a cure for some types of cancer could come out of ORU, which was a dream of the school’s founder, the late Oral Roberts.
Explaining his research, which is ongoing and should not be interpreted as a cure for cancer, Ranahan said that mushrooms are genetically closer to humans than to other plants. They have no mouths and no way to feed themselves, so they design chemicals to break down any material they are growing on and absorb that material as food.
In what he calls a “eureka” moment, Ranahan said, he had the idea of allowing mushrooms to interact with cancer cells, to see if they would design chemicals that could break down the cancer cells.
He looked into published studies and found no one had tried his specific method. Mushrooms have been studied for potential anti-cancer properties for more than a decade, however, and many of those scientists have also developed positive results.
Ranahan needed $50,000 for the initial research, he said, and while he was waiting for a grant to fund the project, someone heard about it and handed him a check for the entire amount.
Working with an engineering student, Ranahan designed an interface that allowed living, growing mushrooms to interact with living cancer cells.
To his amazement, he said, the mushrooms broke down the cancer cells.
“We have mushrooms growing just on cancer. They’ve figured out how to break them down,” he said.
Further testing showed the mushrooms breaking down cancer cells without changing normal, noncancerous cells around them, he said.
“I’m freaking out. This is crazy,” he said. “We’ve taken mushrooms and trained them to destroy, eat, live off of cancer cells. I know that they’re releasing compounds that seem to be selectively destroying cancer cells.
“I don’t know what the compound is. I don’t know if it’s several compounds or one compound. We’re going to have to identify those, and that’s the next step.”
Ranahan said he was an unlikely person to be doing cancer research.
He was raised on a small farm in New Hampshire.
“We lived off of the land; honey bees, vegetable gardens ... mostly splitting wood and shoveling manure.”
When he was 18, he planned to attend the U.S. Naval Academy at Annapolis, looking at a military career, but felt compelled to set aside a week to fast and pray about that decision.
Instead, he went to ORU, graduating in 2005 with a degree in biology. He worked in the biotechnology field in Seattle and eventually went on to do cancer research and get his doctorate at Indiana University School of Medicine.
He was working in cancer research and had an opportunity to go to a top breast cancer lab when he heard about an opening for a professor at ORU.
In a panic, he said, he realized he was supposed to go to Tulsa.
“They were looking for a teacher. I was a researcher,” he said. “My committee busted out laughing. ‘A teaching job? You’re a funny man. ... You’re throwing your doctorate away.’”
But not long after he came to ORU in 2013, he was asked if he would like to do cancer research there, and he set up the Ranahan Cancer Lab.
Bill Sherman
Twitter: @bshermantulsa

1 image
Professor William Ranahan, shown on the campus of Oral Roberts University. BILL SHERMAN/Tulsa World

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ariana is offline   Reply With Quote
Old 03-11-2017, 11:04 AM   #2
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Re: ORU professor explains his breast cancer research breakthrough that's got him 'fr

Very Interesting. While I wish Dr. Ranahan luck and God's blessing on identifying the cancer destroying chemicals it is possible if they are not proteins that you could get them in the bloodstream by taking an extract of this mushroom. Is it poisonous to eat?

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Old 03-11-2017, 02:44 PM   #3
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Re: ORU professor explains his breast cancer research breakthrough that's got him 'fr

I don't know Paul. SEVERAL people in my neighborhood have come down with some form
of breast cancer --news reporter local with triple negative type.

It needs to stop now.
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Old 03-23-2017, 05:07 AM   #4
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Join Date: Sep 2016
Posts: 459
Re: ORU professor explains his breast cancer research breakthrough that's got him 'fr

Interesting read. I’ve read about mushrooms being a potential cancer treatment before, and I’m not sure why they are not doing more research in this regard.

12/15 – First mammogram
01/16 – Second mammogram and ultrasound.
01/16 – Meet surgeon and go for third mammogram, second ultrasound and biopsy. Surgeon confirms cancer in left breast and lymph nodes and sets surgery date.
01/16 – Chest scan and bone scan done– all looks good.
02/16 – Surgery - left breast mastectomy and 16 lymph nodes removed (8 had cancer).
02/16 – CT scan done – small nodules on lung but Doctor advises it’s post surgical. They will continue to monitor just in case.
03/16 – Meet radiation oncologist and find out results of Pathology Report. I’m told that I have locally advanced breast cancer, based on the size of my tumour (7 cm!) and the fact that they found cancer cells in eight lymph nodes. I’m also told that I’m HER 2 positive, with high levels of estrogen and progesterone and that my cancer is stage 3, grade 2.
03/16 – Meet oncologist and am told that my cancer is actually grade 3, and that I should have done chemo before surgery. Too late now!
03/16 – Start first of six doses of chemo (Carboplatin and Docetaxal) and Herceptin (for 18 months).
04/16 – Have port put in.
04/16 – Get second dose of chemo, but Docetaxal is left out due to liver enzymes being high. I was unable to get a full dose of Docetaxal after my first treatment.
06/16 – Finished chemo! One month off and then I start radiation.
06/16 – Start Tamoxifen.
07/16 – First radiation treatment – 24 more to go!
08/16 – Went for Genetic Testing to see if I have the BRCA gene. Tested negative for BRCA I and II
08/16 – Radiation oncologist biopsies “scar tissue” on my chest wall. I am told that I have a local recurrence and need to have rush surgery.
09/16 – Meet surgeon who advises that I need to meet with a plastic surgeon, as they will need to do a skin graft to close me up after surgery. Meet plastic surgeon and all looks good. A surgery date is set for October 4.
09/16 – Go for rush ultrasound, bone scan, breast MRI and CT scan.
09/16 – Meet oncologist who advises that the ultrasound and bone scan results look good, and that MRI shows three small masses at surgery site, but lymph nodes are clear. Still awaiting the results of the CT scan, but we are positive it will look good.
09/16 – Get a call from my oncologist, who advises that CT scan shows small spots on my lungs, and a large lymph node in the middle of my chest. This means the cancer has spread! She looks into getting me funded for TDM-1 and cancels my surgery.
10/16 – Meet oncologist, who advises that I have to take Perjeta before I can take TDM1. I start Perjeta/Herceptin every three weeks for an indefinite amount of time, and Taxol, which I will take two weeks in a row with one week off and then two weeks in a row for 8-16 treatments. Stop Tamoxifen.
10/16 – Meet surgeon, who reviews my CT scan and advises that the spots on my lungs may not be cancer, and that he doesn’t see a lymph node in my chest. He thinks it’s a spot on my lung. I’m feeling very confused! He advises that my oncologist doesn’t want me to have surgery to remove the three small masses on my scar line, as she wants to use them as a way to determine if the treatment is working. He advises that if they have not shrunk in 6 months, he will revisit surgery.
10/16 – CEA blood test to determine Tumour markers. Results were normal (2.7). My doctor advises that this could mean two things: (1) that the treatment is working, and the tumours are shrinking, or (2), that I'm one of those people who never get elevated CEA levels. Given that some people never get an elevated CEA level, this test doesn’t seem very accurate to me! Asked for PET scan, but am told I don’t qualify.
10/16 – Brain MRI – NED!
11/16 - CA-15-30 blood test – Tumour markers are normal at 19.
11/16 – Second CEA blood test – Tumours markers are still normal at 1.6 Second CA-15-30 blood test – Tumour markers are still normal at 19
11/16 – Develop lymphedema and have to wear a sleeve
12/16 – CT Scan shows that the tumors on my lungs and the lymph node in the middle of my chest are shrinking, and that some have resolved. Also, the small masses along my scar line are no longer visible. This means the medication is working!
12/16 – Small “pimple” shows up where old tumour on chest wall was located. Doctor is going to monitor it for now.
01/17 – A second “pimple” shows up on chest wall, as well as a small lump under the skin. My doctor thinks it’s scar tissue and will monitor it for now.
03/17 – Third CEA blood test and CA-15-30 blood test – Both normal at 2.5 and 25
03/17 – CT Chest scan to see if there’s improvement to chest and lungs – results are mixed. The good news is, lymph nodes are stable, there was improvement of previous lung changes due to radiation, and the cancer has not spread to my bones, spine or liver, etc. The bad news is that while some lung nodules remained stable, others increased by 1-2 mm and new ones have shown up. All of them were less than 1cm.
03/17 – Got my genetic test results from Foundation One. It found 11 genomic alterations, 3 therapies associated with potential clinical benefit, and 13 clinical trials from which I might benefit.
03/17 – Second brain MRI –awaiting results
03/17 – Ultrasound scheduled to determine size of “pimples” on my chest wall. They will follow up with a second Ultrasound in three months, to see if they are growing
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Old 07-20-2020, 09:27 AM   #5
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Join Date: Oct 2013
Posts: 471
Re: ORU professor explains his breast cancer research breakthrough that's got him 'fr

I did some research on Reishi mushroom (Ganoderma) which has been used in China against cancer for centuries. Ganoderma contains what are called Triterpenes ( complicated fused ring structure chemicals) and polysaccharides that have anticancer actions, in fact multiple actions.

1. Ganoderma chemicals decrease the production of BCL-2, a protein that in
inhibits apoptosis or cancer cell death

2 Ganoderma increases the amount of BAX protein which increases apoptosis.

3. Ganoderma (Reishi) prevents the action of a protein called NF-Kappa beta which when activated has multiple pro cancer actions like increasing blood vessel formation (angiogenesis) and increasing the activity of MMP proteins that help cancer cells spread.

These are just a few of the anti-cancer actions .

You can get Reishi online easily as it is not a prescription drug.

As far as why research about these various mushrooms isnt done I can probably give you some info as pharmacists have some insight into the politics of cancer. Research is carried out by drug companies as only the drug companies have the money to carry out all of the necessary FDA clinical trials.

Pfizer etc cant patent a mushroom. Therefore the drug companies have little interest in things like anti-cancer mushrooms. You are basically on your own. Still the chemicals in these various mushrooms seem to have multiple anti-cancer actions.

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mushrooms, research

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