Cannabinoid receptors – main ligands are Omega 3 and 6 derivatives, not hemp products

[R.B.]

Cannabinoids have a role in mitochondrial regulation, again confirming the biological importance of these pathways. Much again is unknown.

Again focus on the abstract below is on Omega 6 related endocannabinoids.

These pathways are complex and it is likely plant based endocannabinoids will have a range of impacts on these pathways which may or may not prove to have benificial pharmacological use including in cancers.

Clearly energy pathways are central to brain development, which again brings us back to the question should there be greater public education as to CBD usage, particularly for pregnant females, infants, and adolescents?

Clearly usage in adults is a very different issue, involving, as do many aspects of life, a mix of regulation and person choice.



Cannabinoid-induced changes in respiration of brain mitochondria

https://www.medicinalgenomics.com/wp...tochondria.pdf

"Early studies suggest that cannabinoids affect mitochondrial
function via lipophilic action (Bartova and Birmingham, 1976;
Martin, 1986). Recently, endocannabinoid receptor signaling has
been demonstrated to modulate numerous concomitant patho-
logical processes, including neuroinflammation, excitotoxicity,
mitochondrial dysfunction, and oxidative stress. Endocannabinoids, such as anandamide and 2-arachidonoylglycerol, were found to alter mitochondria-dependent signal transduction and thus participate in the regulation of
energy homeostasis and apoptosis. The upregulation of endocannabinoids may precede mitochondrial dysfunction in neurodegenerative disorders . Some effects of endocannabinoids are independent of their target cannabinoid receptors and are associated with a drug-induced increase in mitochondrial membrane fluidity dissipation of membrane potential, release of accumulated calcium, and opening of mitochondrial permeability transition
pores."


"exogenous and endogenous cannabinoids can activate mitochondrial CB1 receptors and down-regulate mitochondrial respiration. It is hypothesized that mitochondrial CB1 receptors depress mitochondrial respiration and enhance physiological responses mediated by endocannabinoids. We hypothesize that the inhibitory effect of cannabinoids on mitochondrial respiratory rate is caused by the changes in dynamic properties of the lipid part of inner mitochondrial membrane, activation of mitochondrial CB1 receptors, and assembly of respirasomes."