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11-23-2006, 11:40 PM
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#1
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Senior Member
Join Date: Feb 2006
Location: Southern, CA
Posts: 2,511
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Weekly herceptin is better?
On another board one women said their oncologist had been at a conference and told her that a study was done and it showed that herceptin worked better in weekly doses then the 3 week dose. (It was only suppose to be a small difference...but I would like to see the actually results to this study if possible?)
I did a search for this information on google and can't find anything on it? Has anyone here heard this news yet?
Chelee
__________________
DX: 12-20-05 - Stage IIIA, Her2/Neu, 3+++,Er & Pr weakly positive, 5 of 16 pos nodes.
Rt. MRM on 1-3-06 -- No Rads due to compromised lungs.
Chemo started 2-7-06 -- TCH - - Finished 6-12-06
Finished yr of wkly herceptin 3-19-07
3-15-07 Lt side prophylactic simple mastectomy. -- Ooph 4-05-07
9-21-09 PET/CT "Recurrence" to Rt. axllia, Rt. femur, ilium. Possible Sacrum & liver? Now stage IV.
9-28-09 Loading dose of Herceptin & started Zometa
9-29-09 Power Port Placement
10-24-09 Mass 6.4 x 4.7 cm on Rt. femur head.
11-19-09 RT. Femur surgery - Rod placed
12-7-09 Navelbine added to Herceptin/Zometa.
3-23-10 Ten days of rads to RT femur. Completed.
4-05-10 Quit Navelbine--Herceptin/Zometa alone.
5-4-10 Appt. with Dr. Slamon to see what is next? Waiting on FISH results from femur biopsy.
Results to FISH was unsuccessful--this happens less then 2% of the time.
7-7-10 Recurrence to RT axilla again. Back to UCLA for options.
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11-24-2006, 04:05 PM
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#2
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Senior Member
Join Date: Oct 2005
Posts: 115
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What she may be referring to is a study that wa done that showed weekly was better while udergoing radiation treatments. I don't kow the name of the study or where it was done - it was a small study but credible enough for two oncologists and the radiooncologist to insist on weekly thru rads and the three weeks after.
Susanne
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11-24-2006, 05:09 PM
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#3
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Senior Member
Join Date: Feb 2006
Posts: 1,014
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Don't know of the study but my oncologist told me that he has seen better results with the 1 week infusions for advanced cancer...sherryg683
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11-24-2006, 08:34 PM
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#4
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Senior Member
Join Date: Feb 2005
Location: Norridgewock, Maine
Posts: 778
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My oncologist liked weekly as he felt it was easier on the heart with a single dose then triple every 3 weeks. He said if it meant a hardship of traveling he would do the 3 weeks. hugs, Sandy
__________________
Dx. 03/01, Rt. IBC
AC/Taxatere
Rt. MRM-with graft Lt. simple
5 rads-skin mets
Herceptin, taxol, carboplatin (taxol seem to be the magic drug)
Navelbine & xeloda (did not work)
topical miltex for skin mets
Tykerb/xeloda
thoracentesis x 2 left lung fluid shows cancer cells
Port removal (4 years) with power port replacement
Doxil
Updated 05-07 Scans show no bone or organ involvement we shall see!
I shall not pass this way again. Any good I can do or any kindness that I can show let me not defer or neglect it for I shall not pass this way again.
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11-25-2006, 12:12 AM
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#5
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Senior Member
Join Date: Feb 2006
Location: Southern, CA
Posts: 2,511
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Susanne, That may of been the study her onc was talking about. Lower doses of herceptin with rads would be safer I would think. Thanks for passing that along to me. I will have her ask her onc if that is the study she was referring to?
Chelee
__________________
DX: 12-20-05 - Stage IIIA, Her2/Neu, 3+++,Er & Pr weakly positive, 5 of 16 pos nodes.
Rt. MRM on 1-3-06 -- No Rads due to compromised lungs.
Chemo started 2-7-06 -- TCH - - Finished 6-12-06
Finished yr of wkly herceptin 3-19-07
3-15-07 Lt side prophylactic simple mastectomy. -- Ooph 4-05-07
9-21-09 PET/CT "Recurrence" to Rt. axllia, Rt. femur, ilium. Possible Sacrum & liver? Now stage IV.
9-28-09 Loading dose of Herceptin & started Zometa
9-29-09 Power Port Placement
10-24-09 Mass 6.4 x 4.7 cm on Rt. femur head.
11-19-09 RT. Femur surgery - Rod placed
12-7-09 Navelbine added to Herceptin/Zometa.
3-23-10 Ten days of rads to RT femur. Completed.
4-05-10 Quit Navelbine--Herceptin/Zometa alone.
5-4-10 Appt. with Dr. Slamon to see what is next? Waiting on FISH results from femur biopsy.
Results to FISH was unsuccessful--this happens less then 2% of the time.
7-7-10 Recurrence to RT axilla again. Back to UCLA for options.
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11-25-2006, 12:22 AM
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#6
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Senior Member
Join Date: Feb 2006
Location: Southern, CA
Posts: 2,511
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Sherri, I'm glad to hear your onc say that...especially since I have pretty much done weekly. (I've done the 3 week dose three times.) My last one was a three week dose but since I only have till Feb. I think I will go back to weekly. Its a pain in the rear to go in weekly...but I do know I feel better with the weekly. Less of a headache and not as tired. Plus I got my crusty dried out nose this last time again. I have not had that for a LONG time on the weekly.
Plus as Sandy said I do like the idea of it being easier on the heart. Thats a major plus. I do worry more when I get the three week dose...although I have been fine. The weekly just seems like a more even, and well balanced dose.
Chelee
__________________
DX: 12-20-05 - Stage IIIA, Her2/Neu, 3+++,Er & Pr weakly positive, 5 of 16 pos nodes.
Rt. MRM on 1-3-06 -- No Rads due to compromised lungs.
Chemo started 2-7-06 -- TCH - - Finished 6-12-06
Finished yr of wkly herceptin 3-19-07
3-15-07 Lt side prophylactic simple mastectomy. -- Ooph 4-05-07
9-21-09 PET/CT "Recurrence" to Rt. axllia, Rt. femur, ilium. Possible Sacrum & liver? Now stage IV.
9-28-09 Loading dose of Herceptin & started Zometa
9-29-09 Power Port Placement
10-24-09 Mass 6.4 x 4.7 cm on Rt. femur head.
11-19-09 RT. Femur surgery - Rod placed
12-7-09 Navelbine added to Herceptin/Zometa.
3-23-10 Ten days of rads to RT femur. Completed.
4-05-10 Quit Navelbine--Herceptin/Zometa alone.
5-4-10 Appt. with Dr. Slamon to see what is next? Waiting on FISH results from femur biopsy.
Results to FISH was unsuccessful--this happens less then 2% of the time.
7-7-10 Recurrence to RT axilla again. Back to UCLA for options.
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11-25-2006, 01:00 PM
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#7
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Senior Member
Join Date: Sep 2005
Location: Central Coast, CA
Posts: 3,207
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Hi Chelee,
This question comes up a lot and I keep forgetting to ask my onc for "the data" on 1 week vs. 3 week. Maybe it's chemo-brain LOL.
Being on indefinite Herceptin, I should press on this if it makes a difference. So far (thank God) the 3 weekly has been working well with no problems and leaves me plenty of "off weeks" to take exotic vacations...so I hope it is as effective. But if there is evidence I would certainly trade that for a few points on the odds!
By the way, welcome back, glad to see you posting again (I know you've been lurking!)
take care
Chris
__________________
Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial
5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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11-25-2006, 09:08 PM
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#8
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Senior Member
Join Date: Dec 2005
Location: Alexandria, VA
Posts: 1,055
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Hey Chelee,
I'm on the 3 weekly plan. No heart issues. As they say we are making the new stats. H hangs around in your bloodstream for more than 3 weeks which suggest that may be all you need it. Most of the studies were 1 x weekly so that's what they know. I'm trusting my onc on this one. So nice to hear from you again. BB
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11-26-2006, 07:18 PM
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#9
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Senior Member
Join Date: Feb 2006
Location: Southern, CA
Posts: 2,511
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Christy, If you do happen to ask your oncologist what they have heard on this topic of weekly herceptin...I would love to hear his/her reply?
I suppose I can call the makers of herceptin again and find out directly from them if there was such a study? I've called them before and they are great about answering any questions or concerns. I want to know before my next herceptin infusion...if weekly is better...I will just switch back again.
(By the way...thanks Christy and Bev.) 
Chelee
__________________
DX: 12-20-05 - Stage IIIA, Her2/Neu, 3+++,Er & Pr weakly positive, 5 of 16 pos nodes.
Rt. MRM on 1-3-06 -- No Rads due to compromised lungs.
Chemo started 2-7-06 -- TCH - - Finished 6-12-06
Finished yr of wkly herceptin 3-19-07
3-15-07 Lt side prophylactic simple mastectomy. -- Ooph 4-05-07
9-21-09 PET/CT "Recurrence" to Rt. axllia, Rt. femur, ilium. Possible Sacrum & liver? Now stage IV.
9-28-09 Loading dose of Herceptin & started Zometa
9-29-09 Power Port Placement
10-24-09 Mass 6.4 x 4.7 cm on Rt. femur head.
11-19-09 RT. Femur surgery - Rod placed
12-7-09 Navelbine added to Herceptin/Zometa.
3-23-10 Ten days of rads to RT femur. Completed.
4-05-10 Quit Navelbine--Herceptin/Zometa alone.
5-4-10 Appt. with Dr. Slamon to see what is next? Waiting on FISH results from femur biopsy.
Results to FISH was unsuccessful--this happens less then 2% of the time.
7-7-10 Recurrence to RT axilla again. Back to UCLA for options.
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11-27-2006, 07:54 AM
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#10
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Member
Join Date: Apr 2006
Posts: 7
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Actually I asked the question on the BreastCancer.org board. My question was "I went for my 3week dose of herceptin yesterday and my oncol told me the conference she attend recently stated that weekly doses of herceptin are better. I was just wondering if you are all getting the same feed back from your docs as I've seen nothing in writting."
The guest speaker was Christine ???(sorry chemo brain) from Sloan. I have done some research and found that as almost all the studies have been done with weekly dosing that is the recommend dosage. However, those of us getting everythree week doses are paving the way for three week dosage. As I'm currently NED then I have to assume that every three weeks is working well for me. I know for me quality of life is as important as it's length.
Best Wishes,
Deb
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